The candidates will join a very strong core of PHAST scientists devoted to investigating varied aspects of substance use disorders, neurotoxicology, and neurodegenerative disease, including: genetics and genomics bases of alcohol/nicotine/opioid use disorders; mitochondrial stress contribution to FASD; alcohol-induced disruption of fetal brain circulation and developmental consequences; neurocircuitry and neurotransmission involved in compulsive drug-seeking; neurobiological and neuropeptide transmission in the extended amygdala underlying escalated drug self-administration and its relation to stress-susceptibility; subcellular mechanisms underlying alcohol-caffeine, alcohol-lipid, and alcohol-neurosteroid cerebrovascular effects; ionic mechanisms underlying brain hypoperfusion induced by inhalants; cellular and molecular bases of neurodegenerative conditions, including AD, Parkinson's, vascular dementias, and retinal neurodegeneration. The UT Health Science Center College of Medicine offers a generous start up package, and the Institution includes several core facilities, such as the Lab Animal Care Unit, the Regional Biocontainment Laboratory, the Molecular Resource Center, the Flow Cytometry and Flow Sorting core, the Molecular Bioinformatics Core, the Proteomics and Metabolomics Core, the Imaging Core, which houses a super-resolution microscopy unit, the Research Histology Core, a new Structural Biology core with access to several outside core facilities and national labs, and free access to the ISAAC-NG high-performance computing clusters at the University of Tennessee.