NewPrincipal Applied Scientist, ML Codesign Amazon.com Services LLCPrincipal Applied Scientist, ML CodesignSunnyvale, CAFamiliarity with Application-Specific Integrated Circuit (ASIC) development flow, Register Transfer Level (RTL) review, or compiler intermediate representations including Multi-Level Intermediate Representation (MLIR) and OpenXLA. • Eight or more years of industry experience with a track record of first-author or senior-author publications at top-tier venues in machine learning systems, computer architecture, or efficient machine learning.
NewPrincipal Mechanical Engineer JobotPrincipal Mechanical EngineerMountain View, CA$200,000–$260,000 / yearInformation collected and processed as part of your Jobot candidate profile, and any job applications, resumes, or other information you choose to submit is subject to Jobot's Privacy Policy, as well as the Jobot California Worker Privacy Notice and Jobot Notice Regarding Automated Employment Decision Tools which are available at jobot.com/legal. Founded by industry veterans from leading aerospace and satellite organizations, the company has rapidly grown into a team of over 200 engineers, scientists, and innovators focused on building next-generation space infrastructure.
NewSenior Principal Engineer- End-to-End AI Training Framework Bosch Group IncSenior Principal Engineer- End-to-End AI Training FrameworkSunnyvale, CA$240,000–$320,000 / yearAs the Senior Principal Engineer, E2E AI Training Framework for Autonomous Driving Systems, you will spearhead the development and optimization of the machinery that efficiently trains, optimizes, tests, and releases various E2E AI-based products (e.g. The ideal candidate must have prior industry experience in releasing AI-based L2+ systems, with a proven track record of translating innovative research into production-grade solutions.
Sr Scientist/ Associate Principal Scientist, LCMS Platforms CRYSTAL PHARMATECH INCSr Scientist/ Associate Principal Scientist, LCMS PlatformsPleasanton, CA$120,000–$165,000 / yearIndependently propose assay design and/or strategy, develop, validate, conduct, and troubleshoot LCMS-based bioanalytical methods for the quantification of small molecule (and its metabolites) and biologics (e.g. The Bioanalysis & Biomarkers Department specializes in Method Development, Method Validation, GLP/GCLP Bioanalysis for PK, and biomarkers.
NewSenior Scientist / Principal Scientist, Complex in Vitro Systems Genentech IncSenior Scientist / Principal Scientist, Complex in Vitro SystemsSouth San Francisco, CA$120,700–$224,100 / yearResponsibilities include culturing and characterizing state-of-the-art ocular CIVM models, designing and executing model qualification and characterization studies (e.g., advanced imaging, transcriptomics, and functional and phenotypic assays), analyzing and interpreting complex datasets; and maintaining rigorous, high-quality documentation. The Position: The Complex in Vitro Systems (CiS) Lab within the Department of Translational Safety is seeking a highly motivated Senior Scientist / Principal Scientist to develop, characterize, and qualify advanced complex in vitro models to support Genentech's mission of delivering safe and efficacious medicines.
Senior/Principal Machine Learning Scientist, Structure and Simulation (AI for Drug Discovery) Genentech IncSenior/Principal Machine Learning Scientist, Structure and Simulation (AI for Drug Discovery)South San Francisco, CA$147,800–$274,400 / yearIn this role, you will: As a Senior Scientist: • Develop novel machine learning methods to answer challenging research questions in large molecule drug discovery • Work with biological and chemical data from heterogeneous sources • Contribute to an initiative to consolidate projects in machine learning theory into a single coherent model for lab-in-the-loop drug discovery. As a Principal Scientist: • Develop novel machine learning methods to answer challenging research questions in large molecule drug discovery • Work with biological and chemical data from heterogeneous sources • Lead an initiative to consolidate projects in machine learning theory into a single coherent model for lab-in-the-loop drug discovery.
Principal/Sr. Principal Scientist - Development Genentech IncPrincipal/Sr. Principal Scientist - DevelopmentSouth San Francisco, CA$141,500–$262,900 / yearThe successful candidate for Principal/Sr Principal Scientist will provide scientific leadership and play an active role in the process of drug development, with a strong emphasis on Genentech's oncology and cardiovascular, respiratory, and metabolism development project portfolio, which includes small molecules, immunomodulatory biotherapeutics, bi-specific antibodies, ADCs, cancer vaccines and cellular therapeutics. Working in a collaborative team environment, the Principal/Sr Principal Scientist leads the safety assessment of Genentech therapeutics by creating a best-evidence synthesis of existing knowledge and comprehensive investigations of toxicologic activity, strategic planning, and designing/implementing/supervising toxicology studies in support of program advancement.
Senior / Principal Machine Learning Scientist, Scientific Reasoning Models, AI for Drug Discovery Genentech IncSenior / Principal Machine Learning Scientist, Scientific Reasoning Models, AI for Drug DiscoverySouth San Francisco, CA$167,400–$310,800 / yearThe new Computational Sciences Center of Excellence (CoE) is a strategic, unified group whose goal is to harness the transformative power of data and Artificial Intelligence (AI) to assist our scientists in both pRED and gRED to deliver more innovative and transformative medicines for patients worldwide. Research-to-Production Impact: Partner with researchers and cross-functional teams to move models from research prototypes to production-ready systems that support active discovery programs.
Senior Scientist or Associate Principal Scientist, LBA Platforms CRYSTAL PHARMATECH INCSenior Scientist or Associate Principal Scientist, LBA PlatformsPleasanton, CAThe Bioanalysis & Biomarkers Department specializes in Method Development, Method Validation, GLP/GCLP Bioanalysis for PK, immunogenicity and biomarkers. The role is responsible for providing bioanalytical support for both pre-clinical and clinical projects and partnering with our clients for project success.
Senior/Principal AI/ML Computational Scientist Genentech IncSenior/Principal AI/ML Computational ScientistSouth San Francisco, CA$156,200–$290,200 / yearWho You Are: PhD in biomedical engineering, bioengineering, computer science, computational biology, bioinformatics, data science, statistics, computer vision, image analysis, or a related quantitative discipline; Senior Scientist level (0-2 years) Principal Scientist (3+ years of experience). Our work focuses on extracting quantitative, reproducible, and biologically meaningful information from digital histopathology images and related imaging datasets to support preclinical safety assessment, mechanistic investigation, and translational research.
Senior / Principal Scientist, AI for Protein Engineering Lila SciencesSenior / Principal Scientist, AI for Protein EngineeringSan Francisco, CaliforniaWithin Life Sciences AI (LSAI), the AI for Protein Engineering team develops and uses the generative and predictive models that drive Lila's biomolecule design programs from in silico hypothesis to wet-lab validated lead. Full-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program.
Senior / Principal Scientist, AI for Protein Engineering Lila Sciences IncSenior / Principal Scientist, AI for Protein EngineeringSan Francisco, CA$268,000–$358,000 / yearWithin Life Sciences AI (LSAI), the AI for Protein Engineering team develops and uses the generative and predictive models that drive Lila's biomolecule design programs from in silico hypothesis to wet-lab validated lead. Full-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program.
Senior / Principal Scientist, Foundation Models for life Sciences Lila Sciences IncSenior / Principal Scientist, Foundation Models for life SciencesSan Francisco, CA$288,000–$480,000 / yearFull-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program. LILA combines advanced AI models with proprietary AI Science Factory instruments into an operating system for science that executes the entire scientific method autonomously, accelerating discovery at unprecedented speed, scale, and impact across medicine, materials, and energy.
Principal Scientist, Pharmacokinetics Merck & Co IncPrincipal Scientist, PharmacokineticsSouth San Francisco, CA$176,200–$277,300 / yearRequired Skills: ADME, Biochemical Analysis, Biophysics, Cross-Functional Teamwork, Detail-Oriented, Diversity and Inclusion (D&I), Drug Metabolism, Immunoassays, Innovation, Liquid Chromatography-Mass Spectrometry (LC-MS), Mentoring Staff, Pharmaceutical Sciences, Pharmacodynamics, Pharmacokinetics, PKPD Modeling, Therapeutic Proteins. Key Responsibilities of the Principal Scientist: Project-team representative and subject matter expert for biologics drug discovery and development, including but not limited to drug conjugates, multi-specific biologics, and novel modalities.
Senior Principal Scientist, Cardiovascular, Translational Development Bristol-Myers Squibb CoSenior Principal Scientist, Cardiovascular, Translational DevelopmentBrisbane, CAKeeps up-to-date on relevant scientific/technical literature in order to applying external knowledge to internal research programs as appropriate and acts as a subject-matter expert within the team to critically evaluate the literature regarding the asset and disease biology Keeps up-to-date on relevant scientific/technical literature in order to applying external knowledge to internal research programs as appropriate and acts as a subject-matter expert within the team to critically evaluate the literature regarding the asset and disease biology. • Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays.
NewPrincipal Scientist, Global Patient Safety Surveillance Revolution Medicines IncPrincipal Scientist, Global Patient Safety SurveillanceRedwood City, CA$211,000–$264,000 / yearResponsibilities include: Serve as the lead principal subject matter expert for the design, development, maintenance, and support of one or more core GPS processes (i.e. comparative benefit-risk, signal detection & management, risk management, aggregate reporting, etc.) in compliance with applicable Good Clinical Practice (GCP), Good Pharmacovigilance Practice (GVP), Good Documentation Practices (GDocP), etc., in alignment with the company's mission and objectives. The company's RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development.
NewPrincipal Scientist, Global Patient Safety Surveillance Revolution MedicinesPrincipal Scientist, Global Patient Safety SurveillanceRedwood City, CaliforniaServe as the lead principal subject matter expert for the design, development, maintenance, and support of one or more core GPS processes (i.e. comparative benefit-risk, signal detection & management, risk management, aggregate reporting, etc.) in compliance with applicable Good Clinical Practice (GCP), Good Pharmacovigilance Practice (GVP), Good Documentation Practices (GDocP), etc., in alignment with the company’s mission and objectives. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development.
NewPrincipal Environmental Scientist (Natural Resources) Project Resource CollectivePrincipal Environmental Scientist (Natural Resources)Oakland, CaliforniaCollaborating with internal subject matter experts (biologists, archaeologists, GIS specialists, planners, regulatory specialists, and engineers) and external technical partners, protection agencies, and state or federal lead agencies. Experience leading projects/programs and working in dynamic, collaborative environments that require flexibility in assuming new roles and changing project directions.
Principal / Sr. Principal BioML Scientist Lila SciencesPrincipal / Sr. Principal BioML ScientistSan Francisco, CaliforniaCo-architect the AI-for-Cell-Biology platform's scientific direction, partnering with the AI/ML Science and Engineering leads to shape how AI, lab automation, and closed-loop experimentation together change how cell biology is done — what closed loops to run, what cycle times and evidence thresholds matter, what kinds of scientific questions become tractable that weren't before. Shape the team's evaluation framework and scientific bar alongside research and engineering leads by owning what makes a benchmark biologically meaningful, what evidence threshold turns a model output into an experimental decision, and what counts as the platform delivering real new science rather than just well-scored predictions.
Principal / Sr. Principal BioML Scientist Lila Sciences IncPrincipal / Sr. Principal BioML ScientistSan Francisco, CA$288,000–$480,000 / yearCo-architect the AI-for-Cell-Biology platform''s scientific direction, partnering with the AI/ML Science and Engineering leads to shape how AI, lab automation, and closed-loop experimentation together change how cell biology is done - what closed loops to run, what cycle times and evidence thresholds matter, what kinds of scientific questions become tractable that weren''t before. Shape the team''s evaluation framework and scientific bar alongside research and engineering leads by owning what makes a benchmark biologically meaningful, what evidence threshold turns a model output into an experimental decision, and what counts as the platform delivering real new science rather than just well-scored predictions.
Associate Principal Scientist, Respiratory Discovery Merck & Co IncAssociate Principal Scientist, Respiratory DiscoverySouth San Francisco, CA$159,600–$251,200 / yearThis role is suited for a highly independent scientist who can design and execute complex studies, generate high-quality scientific insights, and contribute effectively to cross-functional project teams within a matrixed drug discovery environment.m. Required Skills: Drug Target Identification, Ex Vivo, In Vitro Studies, Program Leadership, Pulmonary Disorders, Respiratory Diseases Prevention, Respiratory Diseases Treatment, Respiratory Pharmacology, Target Validation.
Principal Scientist, Drug Product Process Science Allogene Therapeutics IncPrincipal Scientist, Drug Product Process ScienceSouth San Francisco, CA$155,000–$180,000 / yearThe successful candidate will play a critical role in drug product process characterization and BLA readiness for allogeneic CAR-T therapies, including but not limited to process characterization design and execution, and regulatory‑ready documentation in support of BLA‑enabling and BLA submission activities, and will work closely with cross‑functional partners across MSAT, Quality, Regulatory, Analytical Sciences, and Clinical Operations. Experience working in the pharmaceutical or biotechnology industry that includes elements of new product development, process characterization, formulation development, equipment design and implementation, technology transfers, statistical process control (SPC), and statistical design and analysis of experiments.
Associate Principal Scientist, Discovery Oncology Merck & Co IncAssociate Principal Scientist, Discovery OncologySouth San Francisco, CA$159,600–$251,200 / yearRequired Skills: Biochemistry, Cancer Cell Biology, Cancer Research, Cell Biology, Immuno-Oncology, In Vitro Biology, In Vitro Research, In Vitro Studies, Molecular Biology, Oncology, Tumor Biology. Extensive hands-on in vitro experience designing, executing, and analyzing multi-color flow cytometry and mechanistic cell-based assays (e.g., viability/cytotoxicity, cell cycle, signaling, and immune response readouts).
Associate Principal Scientist, In Vivo Pharmacology Merck & Co IncAssociate Principal Scientist, In Vivo PharmacologySouth San Francisco, CA$159,600–$251,200 / yearCollaborate with cross-functional groups (Biology, Med Chem, DMPK, Safety, etc.) to enable a comprehensive pharmacology strategy that enables robust assessment of target engagement, in vitro/in vivo correlation, PK/PD relationship, and human dose projection. Required Experience and Skills: Quantitative and translational pharmacology expertise with a solid understanding of key pharmacology concepts including target occupancy, in vitro/in vivo correlation, PK/PD, translational biomarker, and methods for human does projection.
Principal Scientist, Protein Engineering Merck & Co IncPrincipal Scientist, Protein EngineeringSouth San Francisco, CA$176,200–$277,300 / yearPhD in Protein Engineering, Biochemistry, Biology, Biophysics, Biotechnology, Bioengineering, Immunology, Pharmaceutical Sciences, Chemistry, Computational Protein Design, or related STEM field with 8+ years of applied experience, or an MS and 10+ year of applied experience or a B.S. and 14+ years of applied experience. Work closely with HT protein engineering and computational protein engineers to integrate augmented designs and computational approaches toward accelerated derisking and optimization of biologics for best-in-class and first-in-class therapeutics.
NewPrincipal Scientist, Drug Product Process Science Allogene TherapeuticsPrincipal Scientist, Drug Product Process ScienceSouth San Francisco, CA$155,000–$180,000 / yearThe successful candidate will play a critical role in drug product process characterization and BLA readiness for allogeneic CAR-T therapies, including but not limited to process characterization design and execution, and regulatory‑ready documentation in support of BLA‑enabling and BLA submission activities, and will work closely with cross‑functional partners across MSAT, Quality, Regulatory, Analytical Sciences, and Clinical Operations. Experience working in the pharmaceutical or biotechnology industry that includes elements of new product development, process characterization, formulation development, equipment design and implementation, technology transfers, statistical process control (SPC), and statistical design and analysis of experiments.
Associate Principal Scientist, Clinical Research Merck & Co IncAssociate Principal Scientist, Clinical ResearchSouth San Francisco, CA$142,400–$224,100 / yearTranslational Medicine (TMed) drives early clinical development of novel therapeutics by partnering with Discovery Sciences and Late-Stage Clinical Research to translate scientific discoveries into human proof-of-concept and advance the most promising candidates through the pipeline to patients. Leads and directs teams through key study planning, development, and execution activities, including program overviews, issue escalation and mitigation, senior management presentations, cross-functional governance meetings, and advisory meeting preparation.
Principal Scientist, Bioinformatics Nkarta, Inc.Principal Scientist, BioinformaticsSouth San Francisco, CA$180,000–$215,000 / yearA central focus of this role is to drive and execute on Nkarta's strategy for single-cell and spatial transcriptomics, leveraging scRNA-seq, spatial, and functional genomics approaches to drive translational insights, biomarker development, and clinical decision-making in early development. Nkarta is a publicly traded (Nasdaq symbol NKTX), clinical-stage biotechnology company headquartered in South San Francisco, focused on advancing the development of allogeneic, off-the-shelf natural killer (NK) cell therapies to treat autoimmune disease.
Senior/Principal Scientist SonoThera IncSenior/Principal ScientistSouth San Francisco, CA$150,000–$206,000 / yearTechnical Requirements & Skills: Demonstrated success in developing potent and safe gene therapy payloads for both viral and non-viral delivery, evidenced by first authorship in peer-reviewed publications, patents, and presentations at major international gene therapy conferences. Work in close connection with project management team and manage vector development activities, leveraging advanced project management tools such as SmartSheet to ensure accurate timelines, resource allocation, and milestone delivery.
Principal Applied Scientist ADOBE IncPrincipal Applied ScientistSan Jose, CA$268,000–$388,000 / yearAdobe's industry-leading offerings including Adobe Acrobat Studio, Adobe Express, Adobe Firefly, Creative Cloud, Adobe Experience Platform, Adobe Experience Manager, and GenStudio enable people and businesses to turn ideas into impact, powered by AI and driven by human ingenuity. Learn more about Adobe life, including our values and culture, focus on people, purpose and community, Adobe for All, comprehensive benefits programs, the stories we tell, the customers we serve, and how you can help us advance our mission of empowering everyone to create.
Sr. Principal Scientist, Clinical Operations Immunology Lead Merck & Co IncSr. Principal Scientist, Clinical Operations Immunology LeadSouth San Francisco, CA$210,400–$331,100 / yearIn a competitive external landscape and fast-paced internal environment, the Immunology Clinical Operations Lead position provides both strategic and operational leadership across early immunology programs, ensuring timely, high-quality execution of clinical studies and clinical pharmacology strategies worldwide. Translational Medicine (TMed) drives early clinical development of novel therapeutics by partnering with Discovery Sciences and Late-Stage Clinical Research to translate scientific discoveries into human proof-of-concept and advance the most promising candidates through the pipeline to patients.
Principal Scientist - Agentic Product ADOBE IncPrincipal Scientist - Agentic ProductCA$248,900–$360,500 / yearDeep, hands-on expertise with large language models - including practical fluency with LLM APIs, prompt engineering at scale, fine-tuning and RLHF concepts, context window management, retrieval-augmented generation, and the operational realities of running LLM-backed systems in production. Adobe's industry-leading offerings including Adobe Acrobat Studio, Adobe Express, Adobe Firefly, Creative Cloud, Adobe Experience Platform, Adobe Experience Manager, and GenStudio enable people and businesses to turn ideas into impact, powered by AI and driven by human ingenuity.
Principal Scientist, Bioinformatics Nkarta IncPrincipal Scientist, BioinformaticsSouth San Francisco, CA$180,000–$215,000 / yearA central focus of this role is to drive and execute on Nkarta's strategy for single-cell and spatial transcriptomics, leveraging scRNA-seq, spatial, and functional genomics approaches to drive translational insights, biomarker development, and clinical decision-making in early development. Nkarta is a publicly traded (Nasdaq symbol NKTX), clinical-stage biotechnology company headquartered in South San Francisco, focused on advancing the development of allogeneic, off-the-shelf natural killer (NK) cell therapies to treat autoimmune disease.
Senior / Principal ML Scientist, Foundation Models for Life Sciences Lila SciencesSenior / Principal ML Scientist, Foundation Models for Life SciencesSan Francisco, CaliforniaFull-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program. LILA combines advanced AI models with proprietary AI Science Factory instruments into an operating system for science that executes the entire scientific method autonomously, accelerating discovery at unprecedented speed, scale, and impact across medicine, materials, and energy.
NewPrincipal Scientist, IVD Reagent Development and Manufacturing Delfi Diagnostics IncPrincipal Scientist, IVD Reagent Development and ManufacturingPalo Alto, CA$180,000–$230,000 / year2+ years of experience developing reagent specifications (format, fill volume tolerance, closure, label, shelf, and in-use stability), reagent integrations with automated platforms, and transferring reagent manufacturing from R&D to an internal department or an external contract reagent manufacturer. 3+ years of developing IVD diagnostic tests with NGS cfDNA/multi-omic assay technologies from plasma (e.g., DNA fragments, RNA, small variants, methylation, or immunoassays) under 21 CFR Part 820 or ISO 13485.
Principal Scientist, Computational Chemistry Eikon Therapeutics IncPrincipal Scientist, Computational ChemistryMillbrae, CA$204,000–$223,250 / yearDeliver virtual screening workflows that leverage physics- and AI-based modeling methods involving ligand- and structure-based methods, ensemble docking, molecular dynamics, and free energy calculations. We seek a Principal Scientist in Computational Chemistry with a demonstrated ability of successfully applying in silico technologies to drive the discovery of quality lead-like molecules against hard to drug therapeutic targets.
Principal Scientist, Analytical Development Sana Biotechnology IncPrincipal Scientist, Analytical DevelopmentSouth San Francisco, CA$200,000–$240,000 / yearPhysical Demands: Employees in this position may be required to perform the following physical activities: standing, walking, and sitting for extended periods of time; frequent use of the hands, fingers, wrist, and greater arm to handle small materials, tools, boxes, and trays; lifting and carrying objects up to 10 Ibs; occasional overhead reaches and lifts; occasional lifts and reaches below the knee; occasional pushing and pulling of materials and objects with moderate forces; occasional crouching/kneeling, twisting, and squatting movements. Act as a key contributor in developing and qualifying pivotal stage potency, immunoassay, and other cell-based methods to support the characterization, process development, release testing, and stability testing of cell therapy products.
Principal Scientist, Lyophilization Development Alamar Biosciences IncPrincipal Scientist, Lyophilization DevelopmentFremont, CAThis role requires the ability to operate with significant autonomy, influence technical direction across programs, and mentor scientists while driving high-impact outcomes for the organization. We believe the next frontier in biology is enabled by measuring proteins at higher sensitivity in highly multiplexed assays at the push of a button, which is something only Alamar can do.
Principal Scientist, Cancer Pharmacology, Translational Research Revolution MedicinesPrincipal Scientist, Cancer Pharmacology, Translational ResearchRedwood City, CaliforniaAs a Principal Scientist in the Cancer Pharmacology team within the Translational Research group, in the Biomedical Discovery Research Department, you will: Provide scientific and strategic leadership for RAS(ON) inhibitor programs by translating mechanistic insights in RAS biology into impactful pharmacology strategies and translational study plans. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development.
Principal Scientist, Cancer Pharmacology, Translational Research Revolution Medicines IncPrincipal Scientist, Cancer Pharmacology, Translational ResearchRedwood City, CA$190,000–$238,000 / yearThe Opportunity: As a Principal Scientist in the Cancer Pharmacology team within the Translational Research group, in the Biomedical Discovery Research Department, you will: Provide scientific and strategic leadership for RAS(ON) inhibitor programs by translating mechanistic insights in RAS biology into impactful pharmacology strategies and translational study plans. The company's RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development.
Principal Applied Scientist Microsoft CorpPrincipal Applied ScientistSunnyvale, CA$142,800–$274,800 / yearStarting January 26, 2026, Microsoft AI (MAI) employees who live within a 50- mile commute of a designated Microsoft office in the U.S. or 25-mile commute of a non-U.S., country-specific location are expected to work from the office at least four days per week. There is a different range applicable to specific work locations, within the San Francisco Bay area and New York City metropolitan area, and the base pay range for this role in those locations is USD $188,000 - $304,200 per year.
Principal Scientist, Downstream Process Development (Contract) - AW Adverum Biotechnologies IncPrincipal Scientist, Downstream Process Development (Contract) - AWRedwood City, CA$80–$90 / hourThe successful candidate will participate in late-stage activities including design and optimization of the process as needed using historical batch data and manufacturing needs; process characterization; and tech-transfer of downstream processes to support clinical and commercial manufacturing. Leveraging the research capabilities of its proprietary intravitreal (IVT) platform, Adverum is developing durable, single-administration therapies designed to be delivered in physicians' offices to eliminate the need for frequent ocular injections to treat these diseases.
Senior Principal Scientist, Neuroscience, Clinical Biomarker, Late Phases, Translational Medicine Bristol-Myers Squibb CoSenior Principal Scientist, Neuroscience, Clinical Biomarker, Late Phases, Translational MedicineBrisbane, CA$184,060–$223,036 / yearBased on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day. Key Responsibilities: Designs and implements program-specific late development biomarker/translational plans, responsible for aiding in creation of clinical protocols, SAPs, SOWs, lab manual, and interfacing with CRO for execution of services, in conjunction with Biospecimen Operations and Procurement.
Senior Principal Machine Learning Scientist, AI Biology & Translation (AIBT) Genentech IncSenior Principal Machine Learning Scientist, AI Biology & Translation (AIBT)South San Francisco, CA$202,800–$376,600 / yearThe new Computational Sciences Center of Excellence (CoE) is a strategic, unified group whose goal is to harness this transformative power of data and Artificial Intelligence (AI) to assist our scientists in both pRED and gRED to deliver more innovative and transformative medicines for patients worldwide. This role is ideal for a researcher with a strong track record in machine learning, sequence modeling, regulatory genomics, and representation learning who is excited about advancing the frontier of AI for biology.
Supervising Principal Scientist, Process Development Cellares CorpSupervising Principal Scientist, Process DevelopmentSouth San Francisco, CA$90,000–$210,000 / yearThe primary focus of this position is to provide organizational leadership and technical insight into the onboarding and optimization of new cell therapy processes to expand and drive continuous improvement of the Cellares platform. Partnering with Cellares enables academics, biotechs, and pharma companies to accelerate drug development and scale out manufacturing, lower process failure rates, lower manufacturing costs, and meet global patient demand.
Principal Scientist, Immunology Jade BiosciencesPrincipal Scientist, ImmunologySan Francisco, CaliforniaRemote$175,000–$190,000 / yearThis role will provide scientific leadership across immunology-driven research activities that support Jade’s pipeline programs, including mechanism-of-action studies, disease biology assessment, indication evaluation, and translational strategy. Design and oversee mechanism-of-action studies to elucidate target biology, pathway modulation, and disease relevance across in vitro, ex vivo, and in vivo models, executed in partnership with CROs.
Principal Scientist - Computational Biology & Translational AI (Oncology Precision Medicine) Amgen IncPrincipal Scientist - Computational Biology & Translational AI (Oncology Precision Medicine)South San Francisco, CA$182,535–$211,139 / yearThis role focuses on pan-asset forward and reverse translation, designing and deploying AI-enabled analytical and agentic systems that connect preclinical, translational, and clinical data to drive mechanistic understanding, biomarker hypotheses, and development strategy across oncology programs. This role is ideal for a scientist who enjoys building AI-enabled translational systems, not just running analyses, and who can integrate clinical, biological, and multi-modal data through modern Generative and Agentic AI to drive forward and reverse translational insight and decision-grade impact.
Principal Scientist - PKDM, Modeling and Simulation Amgen IncPrincipal Scientist - PKDM, Modeling and SimulationSouth San Francisco, CAIn addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. You will work directly with other PKDM stakeholders to apply quantitative solutions in the development of novel therapeutics through various activities including target/compound evaluation, design of preclinical studies, investigation of exposure-response relationships, execution of translational strategies, and influencing clinical study design.
Senior and Principal Applied Scientists - CoreAI Microsoft CorpSenior and Principal Applied Scientists - CoreAIMountain View, CA$119,800–$234,700 / yearThere is a different range applicable to specific work locations, within the San Francisco Bay area and New York City metropolitan area, and the base pay range for this role in those locations is USD $158,400 - $258,000 per year. There is a different range applicable to specific work locations, within the San Francisco Bay area and New York City metropolitan area, and the base pay range for this role in those locations is USD $188,000 - $304,200 per year.
ML Research Scientist, Foundation Models (Senior / Staff / Principal) Genesis Molecular AIML Research Scientist, Foundation Models (Senior / Staff / Principal)San MateoOur generative and predictive AI platform, GEMS (Genesis Exploration of Molecular Space), integrates AI and physics into industry-leading models to generate and optimize drug molecules, including the breakthrough generative diffusion model Pearl for structure prediction. Genesis has also signed category-leading AI-pharma deals, the most recent of which was a significant expansion with Incyte (see coverage in Forbes and GEN) with a total potential deal value of several billion dollars.