Principal Scientist Jobs in the United States
Atrium Staffing
$75 - $90
Boston, MA
Responsibilities of the Principal Scientist (High-Throughput ADME): High-Throughput ADME Assay Development & Automation: Design, develop, optimize, and validate high-throughput in vitro ADME assays, including solubility, MDCK permeability, plasma protein binding, microsomal stability, hepatocyte stability, and CYP inhibition/induction assays. The Principal Scientist (High-Throughput ADME) will play a critical role in scaling ADME screening platforms, delivering high-quality ADME data, and optimizing drug metabolism workflows to accelerate lead optimization.
Atrium Staffing
$70 - $80
Boston, MA
Responsibilities of the Principal Scientist (ADME): Develop, optimize, and validate high-throughput in vitro ADME assays covering solubility, permeability, protein binding, metabolic stability, and enzyme inhibition/induction. The Principal Scientist (ADME) will develop and execute advanced in vitro ADME assays and support accelerated drug discovery by delivering high-quality ADME data for lead optimization.
FM
$117280 - $168600
Norwood, MA
The purpose of this position is to develop new scientific knowledge, technologies and engineering solutions to problems in material flammability, fire dynamics and Lithium-ion battery safety research, which can be used for the prevention or control of industrial property loss. Job Description: Established nearly two centuries ago, FM is a leading mutual insurance company whose capital, scientific research capability and engineering expertise are solely dedicated to property risk management and the resilience of its policyholder-owners.
Joulé
$45 - $70
Rockville, MD
D. in Structural Biology, Biochemistry, Biophysics, Protein Sciences, Computational Biology, Bioengineering, Machine Learning, Computer Science, or related field with 0–3 years postdoctoral experience OR; Master’s degree with 5+ years of relevant industry experience. This is a highly impactful, first-of-its-kind role within the organization, working at the intersection of structural biology, computational modeling, and AI-enabled protein engineering.
Naval Nuclear Laboratory
$105200 - $164400
Niskayuna, NY
Bachelors degree from an accredited college or university in a related technical, engineering or science field and a minimum of 9 years of relevant experience; or Masters degree from an accredited college or university in a related technical, engineering or science field and a minimum of 7 years of relevant experience; or Doctorate degree from an accredited college or university in a related technical, engineering or science field and a minimum of 3 years of relevant experience; or Currently an Principal Reactor Training Engineer, Refueling Engineer, or Field (RPCO) Engineer at the Company. Naval Nuclear Laboratory personnel are FMP employees who work at four DOE facilities: Bettis Atomic Power Laboratory, Knolls Atomic Power Laboratory, Kenneth A. Kesselring Site, and Naval Reactors Facility, and at the U.S. Department of Defense-owned Nuclear Power Training Unit-Charleston.
Naval Nuclear Laboratory
$105200 - $164400
Niskayuna, NY
Bachelors degree from an accredited college or university in a related technical, engineering or science field and a minimum of 9 years of relevant experience; or Masters degree from an accredited college or university in a related technical, engineering or science field and a minimum of 7 years of relevant experience; or Doctorate degree from an accredited college or university in a related technical, engineering or science field and a minimum of 3 years of relevant experience; or Currently an Principal Reactor Training Engineer, Refueling Engineer, or Field (RPCO) Engineer at the Company. Naval Nuclear Laboratory personnel are FMP employees who work at four DOE facilities: Bettis Atomic Power Laboratory, Knolls Atomic Power Laboratory, Kenneth A. Kesselring Site, and Naval Reactors Facility, and at the U.S. Department of Defense-owned Nuclear Power Training Unit-Charleston.
Naval Nuclear Laboratory
$105200 - $164400
Charleston, SC
Bachelors degree from an accredited college or university in a related technical, engineering or science field and a minimum of 9 years of relevant experience; or Masters degree from an accredited college or university in a related technical, engineering or science field and a minimum of 7 years of relevant experience; or Doctorate degree from an accredited college or university in a related technical, engineering, science field and a minimum of 3 years of relevant experience; or Currently a Principal Reactor Training Engineer, Refueling Engineer, or Field (RPCO) Engineer at the Company. Join the Site Projects (SP) team as a Principal Facility Projects Engineer in the Moored Training Ship Directorate/Site Projects, Planning, and Engineering (SPPE) Subdivision supporting the planning, design, and execution of Naval Nuclear Propulsion Program (NNPP) major facility construction projects.
Naval Nuclear Laboratory
$105200 - $164400
Niskayuna, NY
Naval Nuclear Laboratory personnel are FMP employees who work at four DOE facilities: Bettis Atomic Power Laboratory, Knolls Atomic Power Laboratory, Kenneth A. Kesselring Site, and Naval Reactors Facility, and at the U.S. Department of Defense-owned Nuclear Power Training Unit-Charleston. For nearly 70 years, the Naval Nuclear Laboratory has developed advanced nuclear propulsion technology, provided technical support, and trained world-class nuclear operators to ensure the safe and reliable operation of our nation's submarine and aircraft carrier Fleets.
Bowhead / UIC Technical Services
Dahlgren, VA
Data Scientist (E30-2025-22465): Bowhead seeks a Data Scientist with a strong background in data trend analysis to join our team supporting Naval Surface Warfare Center Dahlgren Division (NSWCDD), E Department. Plans, designs, creates, amends, verifies, and documents new and amended software components in order to deliver agreed value to stakeholders.
Naval Nuclear Laboratory
$116700 - $182400
West Milton, NY
The Training Applications and Support (TAS) organization, part of the Naval Training & Simulation (NTS) Department, provides applications used by personnel at the Moored Training Ships (MTS) and Kesselring Site (KS) to manage activities for the Naval Nuclear Propulsion Training Program (NNPTP) Prototype phase of training. Naval Nuclear Laboratory personnel are FMP employees who work at four DOE facilities: Bettis Atomic Power Laboratory, Knolls Atomic Power Laboratory, Kenneth A. Kesselring Site, and Naval Reactors Facility, and at the U.S. Department of Defense-owned Nuclear Power Training Unit-Charleston.
The United States Secret Service
Huntington, VA
Collaborates with intra-agency partners to build and maintain data models, reporting systems, automation, and dashboards using multiple data sources, demonstrating expertise in at least two areas such as cloud platforms, generative Artificial Intelligence (AI), programming, Machine Learning Operations (MLOps), or relevant certifications. Joining the Secret Service, Office of Strategy, Planning, and Innovation will allow you to apply data science and related information management principles to promote effective data use for informed decision-making, and to drive positive transformation in programs and organizational units with advanced analytic, modeling, and evaluation support.
Fusion Life Sciences Technologies LLC
Raritan, NJ
This role partners cross-functionally with suppliers, R&D, Quality, Manufacturing, and Clinical teams to deliver robust, scalable product designs aligned to pre-clinical and clinical outcomes. We are seeking an experienced Formulation Design Lead / Senior Scientist to drive formulation and biomaterials development from early concept through prototyping, validation, and clinical translation.
Duke Health
Mooresville, NC
Coordinate the processing of patient samples or perform processing as needed based on staffing levels using appropriate identification techniques and written procedures to ensure quality material for testing. The smallest of Duke Health's four hospitals at 123-beds, it offers a comprehensive range of medical services, including 24-hour emergency care, cardiology, orthopedics, women's services, and surgical specialties.
Bristol Bay Construction Holdings LLC
$110000 - $150000
Jacksonville, FL
For three decades, our best-value companies have provided federal and commercial clients with superior quality and cost-effective, innovative, and sustainable solutions for construction, restoration services, civil works, fuel systems, environmental services, and facility support services / professional services. The Principal Environmental Engineer will blend deep technical expertise with project management and leadership skills to deliver sustainable, cost-effective solutions across environmental remediation, permitting, impact assessments, and compliance initiatives.
Jobot
$80000 - $125000
Coppell, TX
The role is highly hands-on and strategic, focusing on the development of cutting-edge dietary supplements including vitamins, pre-workouts, amino acids, powders, capsules, tablets, RTDs, and functional beverages. Information collected and processed as part of your Jobot candidate profile, and any job applications, resumes, or other information you choose to submit is subject to Jobot's Privacy Policy, as well as the Jobot California Worker Privacy Notice and Jobot Notice Regarding Automated Employment Decision Tools which are available at jobot.com/legal.
FM
$121000 - $173000
Norwood, MA
The position will directly contribute to industrial property loss prevention, with emphasis on critical business areas and emerging hazards such as data centers, renewable energy industries, automated storage facilities, and operations involving ignitable liquids. Job Description: Established nearly two centuries ago, FM is a leading mutual insurance company whose capital, scientific research capability and engineering expertise are solely dedicated to property risk management and the resilience of its policyholder-owners.
FM
$121000 - $173000
Norwood, MA
FM is seeking a Senior Research Scientist to develop new scientific knowledge, technologies, and engineering solutions to challenges in material flammability, fire dynamics, and fire protection, which can be used and applied by FM to help prevent or control property loss for insured clients. Job Description: Established nearly two centuries ago, FM is a leading mutual insurance company whose capital, scientific research capability and engineering expertise are solely dedicated to property risk management and the resilience of its policyholder-owners.
VSolvit LLC
$150000
Fairfax, VA
Founded in 2006, VSolvit (pronounced 'We Solve It') is a technology services provider that specializes in cybersecurity, cloud computing, geographic information systems (GIS), business intelligence (BI) systems, data warehousing, engineering services, and custom database and application development. Some of these include, but are not limited to, adhering to normal working hours, meeting deadlines, following company policies as outlined by the Employee Handbook, communicating regularly with assigned supervisor(s), staying focused on the assigned tasks, and completing other tasks as assigned.
Frontage Laboratories, Inc.
Exton, PA
cond analyt meth dvlpmnt, validation & sample testg under guidance of Sr Scientist pur to protocols, GLP &/or GMP reg reqmts; doc & rprt testg data; perf tasks accord. - Exton, PA, perf lab testg using LC-MS, SIMOA, MSD, Spectra-Max, ELLA, etc.
Exponent
Bellevue, WA
Leveraging deep knowledge in medicine to address a wide range of complex human health challenges across diverse client sectors, therapies, clinical health endpoints, and patients, delivering scientifically rigorous and impactful solutions. Projects may also include the evaluation of mechanism of action; dose response; health hazard indices; review of medical, scientific and epidemiologic literature; comparative risk research; analyses using data science tools; and/or assistance with regulatory documents and analyses.
Exponent
Seattle, WA
In this role you will lead interdisciplinary project teams that investigate and solve complex problems related to the specification, development, testing, and end-use performance of polymeric materials used in life sciences, consumer products, building and construction applications, infrastructure systems, and automotive components. Candidates must demonstrate a proven track record of managing an active client portfolio that consistently generates at least $1 million in annual revenue within industrial sectors or law firms (excluding revenue derived from government funding for academic research projects).
Fusion Life Sciences Technologies LLC
Raritan, NJ
This role partners cross-functionally with suppliers, R&D, Quality, Manufacturing, and Clinical teams to deliver robust, scalable product designs aligned to pre-clinical and clinical outcomes. We are seeking an experienced Formulation Design Lead / Senior Scientist to drive formulation and biomaterials development from early concept through prototyping, validation, and clinical translation.
Visa Usa Inc
Bellevue, WA
Visa is a world leader in payments and technology, with over 259 billion payments transactions flowing safely between consumers, merchants, financial institutions, and government entities in more than 200 countries and territories each year. Advises on technical specifications during discussions with collaborators (e.g., Product owners, business partners, Cybersecurity) to identify and clarify sophisticated technical or business requirements and identify business needs and upstream and/or downstream system/application dependencies.
Transpire BIO Inc.
Sunrise, FL
Transpire Bio Inc. (TBI), a revenue generating clinical‑stage biopharmaceutical company specializing in development and commercialization of orally inhaled and nasal drug products (OINDPs). TBI is seeking a highly skilled and experienced Senior Scientist / Principal Scientist to lead, manage and execute aseptic fill‑finish operations for sterile drug products.
ANCHOR QEA, LLC
Seattle, WA
Current undergraduate or graduate students majoring in a field related to one of our areas of expertise: Environmental Planning and Management(urban design, landscape architecture, sustainability, historic preservation, etc.). Apply online through Anchor QEA's Open Positions page athttps://www.anchorqea.com/careers/careers-open-positions/.Veterans are encouraged to apply.
Apex Companies LLC
$150000 - $200000
Seattle, WA
Powered by record sales, extraordinary client retention, strategic acquisitions, and an entrepreneurial spirit, Apex Companies is one of the fastest growing engineering and environmental consulting firms in the US.We were recently recognized by the Zweig Group as one of the fastest growing firms in the AEC industry. Apex is expanding its environmental leadership team in theSeattle Metro area, and we're seeking an accomplished Professional Engineer or Geologist to spearhead the continued growth of our regional environmental practice.
The Kraft Heinz Company
$102100 - $127600
Glenview, IL
This position will also serve astheSME foranalytical(example: linking chemistry and sensory)data processing, analysis and modellingto elucidatekey businessinsights byleveragingadvanceddata application software, AI technologyand statisticalprinciplesfor R&Dandfield-to-shelfbusinessdecisions. Demonstrate advanced analytical skills andhands-on experience usingcutting-edgeinstrumentations suchGC-MS and LC-MS.This involvesexpertisein the entireworkflow, from sample preparation and data acquisition to processing, statistical analysis, andcompoundcharacterization in complex food systems.
Bristol Myers Squibb
$112000 - $140000
Princeton, NJ
Key responsibility of this role is to effectively collaborate with a cross functional team of asset scientists with deep disease, drug development and business knowledge to help drive an overall translational strategy, working closely with discovery and early development teams, late clinical development as well as with our team of laboratory scientists. + Leads small and large collaborations with academia and industry partners to identify biobanks, clinical trials and existing databases to collate multi-parameter genomic, immune and clinical datasets to mine for novel biomarkers of unmet need patients in conjunction with computational biologists, data scientists and statisticians.
CPCCo
Richland, WA
At Central Plateau Cleanup Company (CPCCo), located in Richland, Washington, we are working to provide a sustainable future for the historic Hanford area through the protection of the Columbia River and the remediation of the Central Plateau. To achieve our mission, we need exceptionally talented, innovative, and driven people to help us reduce risks on the Hanford Site by removing some of the most hazardous waste streams and facilities in the Department of Energy (DOE) complex.
Tenvie Therapeutics
South San Francisco, CA
Its portfolio of wholly owned, highly brain-penetrant, and precision-designed peripherally restricted small molecules address three key drivers of disease: resolving inflammation, rescuing metabolic dysfunction, and restoring lysosomal function. Reporting to the Senior Director, DMPK & Clinical Pharmacology, this role will represent the DMPK function on projects, guiding and implementing strategies and enabling timely data-driven decision-making throughout the life cycle of small molecule therapeutics.
The Kraft Heinz Company
$118400 - $148000
Glenview, IL
This is an ideal opportunity for a scientist passionate about leading the design of experiments, root cause analysis studies, and build shelf life kinetic and predictive models that translate lab and process data into actionable product development strategies, shelf life optimization protocols and product risk insights. Hands-on lab experience using cutting-edge food and beverage analytical instrumentations This involves expertise in the entire workflow, from knowledge of sample preparation and data acquisition to processing, statistical analysis, and compound characterization in complex food systems.
The Kraft Heinz Company
$120800 - $151000
Glenview, IL
In addition, this role may periodically be required to work from or visit the Kraft Heinz North American Headquarters at the Aon Center in downtown Chicago to support meetings with senior leadership, cross-functional partners, and key stakeholders. · End-to-End Project Leadership: Lead and oversee consumer experience projects from inception to completion, ensuring statistical rigor is embedded in the research design and that findings directly influence R&D innovation roadmaps.
Bristol Myers Squibb
$123000 - $145000
Princeton, NJ
Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. PMBATS leads internal and external bioanalytical and diagnostic research & development activities to support multiple disease areas of interest including hematological malignancies, inflammatory disease programs, neuroscience, cardiovascular, and solid tumor indications.
Blue Origin LLC
Seattle, WA
and/or transports placardable amounts of hazardous materials by ground in any vehicle on a public road while in commerce, may be subject to additional Federal Motor Carrier Safety Regulations including: Driver Qualification Files, Medical Certification (obtained before onboarding), Road Test, Hours of Service, Drug and Alcohol Testing (CDL drivers only), vehicle inspection requirements, CDL requirements (if applicable) and hazardous materials transportation/shipping training. Required for Certain Job Profiles: Drivers who operate Commercial Motor Vehicles with a Gross Vehicle Weight (GVW), Gross Vehicle Weight Rating (GVWR) or combination of power unit and trailer that meets or exceeds 10,001 lbs.
Bristol Myers Squibb
$127000 - $159000
Seattle, WA
Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. The Senior/Principal Scientist should possess significant hands-on experience in ligand binding/antibody assay development and demonstrate capability in collaborating with other groups, such as discovery research, product sciences, process development, and QC.
Farallon Consulting
$120000 - $160000
Bellevue, WA
Minimum of 15 years of professional experience in environmental consulting, including planning and performing site investigations, design and operation of remediation systems in Washington State including air-sparge, soil vapor extraction, multi-phase extraction, in-situ remediation, mass excavation, and implementation of engineering controls. Farallon provides full support environmental consulting services to a wide range of private- and public-sector clients including environmental due diligence, site investigation and cleanup, engineering and remediation services, stormwater management, natural resources and permitting, and mediation and litigation support.
Blue Origin LLC
Seattle, WA
and/or transports placardable amounts of hazardous materials by ground in any vehicle on a public road while in commerce, may be subject to additional Federal Motor Carrier Safety Regulations including: Driver Qualification Files, Medical Certification (obtained before onboarding), Road Test, Hours of Service, Drug and Alcohol Testing (CDL drivers only), vehicle inspection requirements, CDL requirements (if applicable) and hazardous materials transportation/shipping training. Required for Certain Job Profiles: Drivers who operate Commercial Motor Vehicles with a Gross Vehicle Weight (GVW), Gross Vehicle Weight Rating (GVWR) or combination of power unit and trailer that meets or exceeds 10,001 lbs.
Blue Origin LLC
Seattle, WA
and/or transports placardable amounts of hazardous materials by ground in any vehicle on a public road while in commerce, may be subject to additional Federal Motor Carrier Safety Regulations including: Driver Qualification Files, Medical Certification (obtained before onboarding), Road Test, Hours of Service, Drug and Alcohol Testing (CDL drivers only), vehicle inspection requirements, CDL requirements (if applicable) and hazardous materials transportation/shipping training. Required for Certain Job Profiles: Drivers who operate Commercial Motor Vehicles with a Gross Vehicle Weight (GVW), Gross Vehicle Weight Rating (GVWR) or combination of power unit and trailer that meets or exceeds 10,001 lbs.
Berkshire Hathaway Specialty Insurance Company
$196914
Seattle, WA
Critically evaluate vendor catastrophe models and datasets to determine applicability to specific accounts, regions, and perils via the application of data science principles, probability, and statistics, with the ultimate goal of determining the validity of these advanced models to identify potential economic loss metrics during a natural or man-made catastrophe event. Support the Catastrophe Engineering and Analytics (CAT E&A) team through conducting independent research and providing leadership in identifying and applying cutting-edge data science techniques to build a better view of the catastrophe risk for multiple natural and man-made perils.
T-Mobile USA, Inc
Bellevue, WA
Day to day activities or responsibilities include: conducting market research; generating product requirements; determining specifications; defining long-term strategy of the product; creating the product road map; helping drive and support technical delivery end to end; defining scope for releases/product increments; partnering. Principal Product Manager is a "jack-of-all-trades" leveraging deep customer empathy, strategic thinking, commercial, analytical, and leadership prowess to successfully deliver delightful and differentiated products that drive growth and positively impact customers lives.
T-Mobile USA, Inc
Bellevue, WA
Day to day activities or responsibilities include: conducting market research; writing features or user stories; determining specifications; defining long-term strategy of the product; creating the product road map; driving technical delivery end to end; defining scope for releases/product increments; partnering with development, project/program management, marketing, and other key stakeholders to define release schedule; and support/drive go-to-market activities as needed. The Technical Product Manager is the ultimate "jack-of-all-trades" leveraging deep customer empathy, strategic thinking, commercial, analytical, technical capability and knowledge, and leadership prowess to successfully deliver delightful and differentiated products that drive growth and positively impact customers lives.
Pfizer
$120800 - $201400
Groton, CT
Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act.
Boehringer Ingelheim
$140000 - $222000
Ridgefield, CT
Independently proposes, design and performs scientific experiments with a predefined goal including developing new methodologies, protocols and or test procedures that contribute to core group/research goals and reflect expert knowledge; Direct and oversee experimental design and results of technicians and junior level scientists. Candidates must have a strong knowledge in immunology with drug discovery experience in rheumatological diseases and a proven track record of productivity both independently (with minimal supervision) and within a team setting in a matrix and collaborative environment.
Bristol Myers Squibb
$136960 - $165964
New Brunswick, NJ
Located at our either our New Brunswick or Lawrenceville facilities in NJ, the exceptional organic chemist joining our Chemical Process Development organization will: Lead chemistry teams to deliver disruptive science, novel chemical routes, robust and well characterized manufacturing processes and outstanding scientific knowledge to support the development and commercialization of our portfolio. Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.
CrowdStrike, Inc.
$195000 - $290000
Redmond, WA
This is a hybrid role based near either our Sunnyvale, CA (CA Bay Area), Redmond, WA (Seattle, WA Area) or Austin, TX offices, with an expectation of approximately two days per week in-office to foster collaboration with other team members within the teams. We base all employment decisions--including recruitment, selection, training, compensation, benefits, discipline, promotions, transfers, lay-offs, return from lay-off, terminations and social/recreational programs--on valid job requirements.
Kymera Therapeutics
$145000 - $215000
Watertown, MA
Partner closely with CMC colleagues and QA to (i) write or review test methods, SOPs, analytical data summaries (CoT/CoA), protocols, and technical reports, (ii) critically review, trend, and interpret analytical testing results, and (iii) support investigation of nonconformances (OOS/OOT results, deviations, etc.). Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions.
Bristol Myers Squibb
$184720 - $223800
Cambridge, MA
The role of Senior Principal Scientist within Discovery Biotherapeutics, Selection Technologies involves leading a high-performing team that is responsible for conducting selections using in vitro display platforms such as yeast and mRNA display to discover binders against targets of interest. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility.
Genezen
$120000 - $160000
Lexington, MA
Lead transfer and validate next generation analytical procedures for the testing of viral vectors, cell banks and gene therapy products in support of Genezen's services and commercial products in compliance with company policies and procedures and regulatory guidelines. Nearby Indianapolis is home to professional and college sports teams, the Indy 500, a growing art community and the world's largest children's museum--to name just a few reasons why this area is a great place to live.
Candel Therapeutics
Needham, MA
Candel is a clinical-stage biopharma company developing off-the-shelf, multimodal immunotherapies that stimulate personalized, systemic anti-tumor responses. With positive Phase 3 results for our lead candidate, it’s an exciting time to join us and help bring transformative cancer treatments to patients.