San Francisco, CA30+ days ago
Pre-clinical characterization and mechanistic elucidation of small-molecule drug candidatesMechanistic studies of cancer cell signaling and PTM analysisPhenotypic assay development for cancer drug discovery (low to high throughput)Small molecule drug development campaigns (hit discovery, hit validation, dose-response studies, SAR and MOA studies)Proficiency in: Managing a team of exceptional scientists and research associatesTarget/indication selectionAnimal models of cancer (GEMM, orthotopic, xenograft models), in vivo study design, and PK/PD interpretationManaging CROs for in vitro and in vivo studiesGrant writingNice to have:Experience navigating IND-enabling studies and working on teams that have successfully advanced research to the clinicExperience working at the interface of cancer biology and chemistry Familiarity or experience with PROTAC/next-gen IPM technologiesExperience with PPI techniques (e.g., BRET, APEX/BioID, AlphaScreen etc.)BenefitsStrong equity incentives. Strong experience with:Cellular and molecular biology, including cancer cell line work and associated assays, stable cell line generation (lentiviral and CRISPR-based systems), co-IP/pull-down assays, RNA-seq, global proteomics, flow cytometry, plasmid design/cloning etc.