Senior Scientist, Research

Overview:

The Research Department at Alnylam is seeking a highly motivated Sr. Scientist in Delivery Biology to support and advance targeted delivery strategies for oligonucleotides. This role will focus on discovering delivery solutions in priority tissue/cell types with compelling therapeutic targets. The successful candidate will have experience working on multiple tissue/cell types, and can apply to new tissues of interest. The focus will be on solving delivery for therapeutic targets of interest that advance as programs in clinical development. The individual will need excellent collaboration and communication skills, connecting interdisciplinary team members from medicinal chemistry, core delivery technology group and targets team. Expertise in oligonucleotide conjugate delivery is essential. This is a lab-based role at our Cambridge site.

Key Responsibilities:

• Develop and apply assays and experimental strategies to enable tissue specific delivery of oligonucleotides conjugates
• Design, execute, and interpret in vitro and ex vivo assays to evaluate delivery efficiency and biological outcomes
• Collaborate extensively with cross‑functional partners focused on expanding targeted delivery into new cell types and tissues.
• Transparently communicate data, conclusions, and experimental rationale to team members and leadership
• Mentor and support the scientific development of junior scientists or research associates

Qualifications:

• PhD in Cell Biology, Molecular Biology, Immunology, Biochemistry or related field.
• 2-3 years of experience in biophparma setting
• Expertise in tissues/cell biology with experience in working with multiple tissue types for cell/tissue specific delivery
• Experience in the field of nucleic acids or antibody drug conjugates aimed at tissue specific delivery will be a plus
• Demonstrated scientific rigor, attention to detail and data reproducibility
• Excellent communication and interpersonal skills, with the ability to effectively collaborate across multidisciplinary teams.

About Alnylam

We are the leader in RNAi therapeutics - a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Before applying, please review Alnylam's Candidate Privacy Notice regarding how Alnylam handles Personal Data you provide with your application for employment.