Senior / Principal Scientist

Neuroimmune Modeling & Discovery

Brain Health for Life. We seek passionate and talented scientists and technologists with insight to harness the neuroimmune system for brain health. Please reach out to us at jobs@modulobio.com regarding the open roles, or if you know youd be a key multiplier for our mission.

Company Overview (www.modulo.bio )

Modulo Bio is a neuroimmunology company that harnesses the power of machine learning, patient iPSC derived cellular modeling and large scale CRISPR screening to develop therapies for neurodegenerative diseases like ALS and Frontotemporal dementia that currently have no effective treatments. Our team specializes in integrating powerful tools like stem cell engineering, multiomics data analysis, and high-throughput automation to discover and modulate neural cells into disease-context and patient-specific protective states.

Overview

Modulo Bio is seeking a Senior/Principal Scientist to build and lead a research group focused on induced-pluripotent stem cell (iPSC)-based in vitro model and technology development. This new team will help to enable Modulo's proprietary immune cell modeling platform, which incorporates human genetics, functional genomics, molecular biology, cellular and tissue profiling, disease model engineering, and advanced computational methodology.

The successful candidate will build a complex cell model platform with the goal of improving our understanding of human biology and therapeutic interventions to inform early and late stage pipeline efforts. Candidates with an eagerness to work within a highly leveraged, team-driven, dynamic research environment will be prioritized. The candidate will work in close collaboration with our internal Computational Biology group which is focused on next-generation sequencing (NGS), functional genomics, cell or tissue profiling, and bioinformatics analyses of cutting-edge large-scale genetic screening or single-cell technologies to enhance our analytic capabilities and to reveal the underlying mechanisms of human disease.

Expertise developing and/or applying iPSC in vitro systems is critical. Cell line and organoid experience is a plus. Practical experience with in vitro model development for neurodegeneration, neurological disorders, or regenerative medicine is desirable.

Location is in San Diego

Requirements

PhD in Genetics, Molecular Biology, Developmental Biology, Biochemistry, Regenerative Medicine, Neuroscience, or related field

3+ years of experience establishing disease models from human iPSCs; hands-on experience with both 2D and 3D co-cultures a plus

Practical expertise with advanced genome editing tools (CRISPR, RNAi, degrons, etc.) and applications for cell engineering or functional genomic screens

Experience with cellular reprogramming highly desirable

Experience developing or analyzing single cell assays (scRNA-seq, scATAC-seq, spatial transcriptomics, etc.) is advantageous

Sustained, impactful record of scientific contributions and documented evidence of iPSC-related expertise, as evidenced by publications, patents, and presentations

Demonstrated leadership capability both within and across teams

Exceptional organizational and communication skills

Responsibilities

Build and lead a foundational stem cell model engineering and chemo/genomic screening effort

Routine engagement with leadership to co-develop research and technology-focused programs

Regular and effective communication with internal and external partners

Identify, evaluate, and engage new CRO or partnering opportunities to enhance throughput

Collaborate effectively with informatics and software development teams

Incorporate state-of-the-art screening, imaging, and/or automation solutions for stem cell culture and method development

Establish an industry-leading, externally-recognized research program, publish discoveries in high-impact journals, attend and present at conferences

Please contact jobs@modulo.bio for more information.