Senior Associate Scientist, Delivery Technology

Overview:

The Research Department at Alnylam is seeking a motivated and skilled Senior Associate Scientist to join our innovative targeted delivery team. The successful candidate will provide critical hands-on support for ligand discovery projects. This role offers an excellent opportunity to work with cutting-edge technologies, contribute to the development of novel therapeutics, and grow within a dynamic and collaborative research environment.

This is an onsite lab-based position and will be primarily located in Cambridge, MA.

Key Responsibilities:

• Support ligand discovery campaigns by executing key experiments for ligand discovery, screening, and characterization under the guidance of project leads.
• Perform high-throughput screening and selection using cell-based assay.
• Execute Next-Generation Sequencing (NGS) workflows, including library preparation from single cells.
• Perform standard molecular biology techniques, including PCR, plasmid preparation, and cloning.
• Run and assist in the development of automated, high-throughput screening assays to characterize ligand properties such as affinity, specificity, and internalization.
• Maintain detailed and accurate records of all experimental work and data in electronic lab notebooks.
• Collaborate closely with other members of the cross-functional team to ensure project goals are met.
• Assist in data analysis, interpretation, and the preparation of presentations for internal meetings.

Qualifications:

• BS/MS in Biology, Cell/Molecular Biology or related field with 3-6 years of work experience, preferably in an industrial setting. Familiarity with flow cytometry and NGS library preparation is required.
• Hands-on experience with standard molecular biology techniques (e.g., PCR, cloning, DNA/RNA extraction) is required.
• Experience with mammalian cell culture and cell-based assays is highly desirable.
• Direct experience with single B cell isolation and screening technologies is a significant plus.

About Alnylam

We are the leader in RNAi therapeutics - a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

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