Scientist II - LNP Formulation

The Fountain Group is currently seeking a LNP Formulation Scientist for a prominent client of ours. This position is located in San Diego, CA. Details for the position are as follows:

Job Description:

• Formulate and optimize LNPs encapsulating nucleic acids, including mRNA, siRNA, or DNA.

• Execute Design of Experiments (DoE) screening campaigns to evaluate LNP compositions and processing parameters.

• Characterize LNPs and analyze, interpret, and present experimental results.

• Support early-stage formulation development, cryoprotection, scale-up, and stability studies as needed.

• Maintain detailed laboratory records and support routine lab operations, including inventory, ordering supplies, buffer preparation, and autoclaving.

• Collaborate with cross-functional teams to fulfill formulation requests.

Qualifications:

• Bachelor's degree in Chemistry, Biochemistry, Chemical Engineering, or a related field with 5+ years of biopharma industry experience, or a Master's degree with 2+ years of industry experience.

• 2+ years of hands-on LNP formulation experience, including nucleic acid encapsulation.

• Experience with LNP characterization techniques, including:

  • Dynamic Light Scattering (DLS)

  • Zeta potential

  • Ribogreen assays

• High proficiency in Microsoft Excel.

• Strong data analysis, documentation, organizational, and communication skills.
• Demonstrated attention to detail and ability to generate reproducible experimental data.

Preferred Qualifications

• Experience preparing targeted LNPs, including mAb-, Fab-, scFv-, or VHH-coated LNPs.

• Experience with immune cell delivery.

• Familiarity with statistical and data analysis software such as JMP or GraphPad Prism.

• Experience with DoE-based formulation screening.

If you are interested in hearing more about the position, please respond to this posting with your resume attached.

Please forward this posting to any friends or colleagues as we do offer a Referral Bonus for any candidate hired.

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