Job Title: Scientist II - Analytical
Job Location: Onsite in San Diego, CA, 92111
Job Duration: 6 month contract, with extensions possible.
Position Summary:
Genentech is searching for an outstanding Scientist II to join the Gene Medicines team in San Diego, CA. This position offers an exciting opportunity to work with new non-viral nucleic acid delivery tools for in vivo genome editing and gene therapy applications. This person will be engaged in the analysis of novel lipid nanoparticle-based pharmaceuticals.
Responsibilities may include but are not limited to:
• Work at the direction of Analytical scientists to analyze lipid nanoparticles (LNPs) encapsulating nucleic acids and LNP components using HPLC and Biolayer Interferometry (BLI)
• Develop methods to characterize LNPs and LNP components
• Establish relationships between physiochemical characteristics of experimental nanoparticle formulations and their efficacy and safety
• Maintain detailed records of analytical data
• Interface directly with other functional teams
• Share responsibility for basic lab management activities (supply ordering, instrument calibration, maintaining schedules)
Requirements, Knowledge, Skills, and Abilities:
• Masters or Bachelors degree with 5+ years experience in pharmaceutical sciences, bioengineering, chemical engineering, chemistry, or related scientific discipline (an equivalent combination of education and experience may be considered).
• Experience developing methods in gradient-elution HPLC modalities such as RP, IPRP, or AEX is required
• Experience with BLI or Surface Plasmon Resonance (SPR) is highly desirable
• Experience with LCMS is desirable
• Excellent attention to detail and ability to produce consistent results and effectively communicate them to the team
• Ability to be a team player, multitask and work on multiple projects at once, and excel in a collaborative work environment.
• Proficiency at MS Excel is required; prior experience with advanced analytical software (Prism, JMP) is desirable
• Excellent oral and written communication skills