Research Assistant | Laboratory of Chemical Immunology and Proteomics
Rockefeller University
- New York, NY
- 16 days ago
Highlights
By developing and applying innovative chemical proteomic profiling technologies, we aim to enrich our understanding of the molecular differences between pathologic and physiologic states in immune cells and cells of the nervous system and to leverage them from a pharmacological perspective for the development of new therapies that not only target specific immune cell subtypes, but also the defined activation states of these cells. The position will involve conducting experiments using primary immune cells, molecular and cellular biology techniques, and supporting studies using mouse models of neuroinflammation.
Numbers & Facts
| Location | New York, NY |
| Industry | Education |
| Company Size | 2,500 to 4,999 employees |
| Year Founded | 1901 |
| Website | http://www.rockefeller.edu/ |
Description
Organization Overview
The laboratory of Chemical Immunology and Proteomics applies synthetic chemistry, chemical biology, and proteomics methods toward the goals of discovering and characterizing (a) novel selective chemical probes that perturb the functions of key proteins regulating immunological and neuroimmunological processes; (b) new mechanisms for small molecule-induced protein degradation; and, more broadly, (c) the pharmacological landscape and signal transduction pathways in immune and neuroimmunological disorders. By developing and applying innovative chemical proteomic profiling technologies, we aim to enrich our understanding of the molecular differences between pathologic and physiologic states in immune cells and cells of the nervous system and to leverage them from a pharmacological perspective for the development of new therapies that not only target specific immune cell subtypes, but also the defined activation states of these cells. Please see www.vinogradovalab.com for more information.
Overview
The Research Assistant will support ongoing research projects investigating the molecular mechanisms regulating immune cell function, with a focus on T helper cell biology and neuroinflammation. The position will involve conducting experiments using primary immune cells, molecular and cellular biology techniques, and supporting studies using mouse models of neuroinflammation.
Responsibilities
Responsibilities include:
- Conduct experiments investigating T helper cell activation, differentiation, and function.
- Perform molecular and cellular assays, including flow cytometry, immunoblotting, and other biochemical techniques, to characterize immune cell responses.
- Assist a postdoctoral researcher with animal studies investigating neuroinflammation.
- Analyze experimental data, maintain accurate laboratory records, and participate in laboratory meetings and discussions of research findings.
- Prepare reagents, maintain laboratory supplies and equipment, and support routine laboratory operations.
Qualifications
REQUIRED QUALIFICATIONS:
- Bachelor s degree in biology, biochemistry, immunology, molecular biology, or a related scientific discipline.
- A minimum of 2 years of extensive laboratory research experience through undergraduate coursework, internships, or independent research projects.
- Familiarity with basic molecular and cellular biology techniques.
- Strong organizational skills, attention to detail, and ability to maintain accurate experimental records.
- Excellent communication skills and ability to work both independently and collaboratively in a research environment.
- Willingness to work with laboratory mice and complete required institutional training.
PREFERRED QUALIFICATIONS:
Experience with some of the following cell and molecular biology techniques:
flow cytometry
PCR/RT-PCR
SDS-PAGE
Western blot
cloning
viral transduction
CRISPR-Cas9 gene editing
protein expression
biochemical assay development
Experience working with murine models is a plus
The Rockefeller University is an equal opportunity employer - veterans/individuals with disabilities. Qualified applicants will receive consideration for employment without regard to characteristics protected by applicable local, state or federal law, including but not limited to disability and protected veteran status.
The salary of the finalist selected for this role will be set based on various factors, including but not limited to organizational budgets, qualifications, experience, education, licenses, specialty, and training. The hiring range provided represents The Rockefeller University s good faith and reasonable estimate of the range of possible compensation at the time of posting.
Compensation Range: Min
USD $50,000.00/Yr.
Compensation Range: Max
USD $55,000.00/Yr.
About Company
Founded by John D. Rockefeller, the Rockefeller Institute for Medical Research was incorporated on June 14, 1901. It was the first institution in the United States devoted solely to biomedical research--to understanding the underlying causes of disease. Today, renamed Rockefeller University, it is one of the foremost research centers in the world, contributing to 23 Nobel Prizes as well as numerous other awards. Rockefeller University Community
Rockefeller University researchers achieved many of the last century's seminal advances in the biomedical sciences, including:
The university's laboratory-based organizational structure "without walls" and pared-down layers of administration do away with the schools and academic departments that too often separate scientists. "This approach fosters a tremendously rich soup of interdisciplinary research and collaboration," says Rockefeller professor and Nobel laureate Günter Blobel. Acclaimed scientists
In its history, Rockefeller has been associated with 23 Nobel laureates and 19 Lasker Award recipients. Five faculty members have been named MacArthur Fellows and 12 have garnered the National Medal of Science, the highest science award given by the United States. And, 33 Rockefeller faculty are elected members of the National Academy of Sciences. Partnerships with other leading institutions
Rockefeller has close ties with neighboring Weill Medical College of Cornell University, New York-Presbyterian Hospital and Memorial Sloan-Kettering Cancer Center. Additional academic partnerships with the Courant Institute of New York University and Bard College provide students with a rich array of training opportunities. Rockefeller forges collaborations with biotech and pharmaceutical companies as needed to speed research findings into development to improve patient care.Clinical research hospital
In 1910, Rockefeller scientists founded the nation's first hospital devoted exclusively to experimental medicine. The Rockefeller University Hospital's only patients are participants in clinical trials building on basic research findings from Rockefeller labs. This "allows the university to maintain an unbroken spectrum of research, from basic to clinical," says Joshua Lederberg, Nobel laureate and Rockefeller president emeritus. Unburdened by constraints of standard patient care, the hospital is a vital component of Rockefeller's commitment to accelerating basic research findings on their route from bench to bedside for the diagnosis, treatment and prevention of disease. Studies are under way on AIDS/ HIV, obesity, hepatitis C and addictive diseases. More than science
Artistic and intellectual activity flourishes on Rockefeller's campus. The verdant grounds, situated on Manhattan's Upper East Side, boast a world-class art collection. The university regularly hosts events designed to explore the intuitive connection between science and the arts.Weekly and monthly recital series grace the university's spectacular auditorium, and a variety of exhibits regularly take shape on campus -currently including sculpture on temporary exhibition from New York's Museum of Modern Art. Select graduate student body
A class of Ph.D. and M.D.-Ph.D. students from across the United States and the world works closely with international faculty in a rigorous, highly personalized program of graduate study and research. The university offers graduate students access and opportunities to work with leading scientists, as well as full financial support and affordable on- and off-campus housing. University budget
Funding the research studies of The Rockefeller University's scientists are the National Institutes of Health and other government agencies, Howard Hughes Medical Institute, private gifts and endowment income.
- 71 heads of laboratories
- 200 research and clinical scientists
- 350 postdoctoral investigators
- 1,050 support staff
- 150 Ph.D. students
- 50 M.D.-Ph.D. students
- 887 alumni
- biochemistry, structural biology and chemistry
- molecular, cell and developmental biology
- immunology, virology and microbiology
- medical sciences and human genetics
- neuroscience
- physics and mathematical biology
Rockefeller University researchers achieved many of the last century's seminal advances in the biomedical sciences, including:
- Discovering that DNA is the basic material of heredity (1944)
- Determining that cancer can be caused by a virus (1911)
- Confirming the connection between cholesterol and heart disease (1950s)
- Developing methadone maintenance for people addicted to heroin (1960s)
- Developing the AIDS "cocktail" drug therapy (1990s)
The university's laboratory-based organizational structure "without walls" and pared-down layers of administration do away with the schools and academic departments that too often separate scientists. "This approach fosters a tremendously rich soup of interdisciplinary research and collaboration," says Rockefeller professor and Nobel laureate Günter Blobel. Acclaimed scientists
In its history, Rockefeller has been associated with 23 Nobel laureates and 19 Lasker Award recipients. Five faculty members have been named MacArthur Fellows and 12 have garnered the National Medal of Science, the highest science award given by the United States. And, 33 Rockefeller faculty are elected members of the National Academy of Sciences. Partnerships with other leading institutions
Rockefeller has close ties with neighboring Weill Medical College of Cornell University, New York-Presbyterian Hospital and Memorial Sloan-Kettering Cancer Center. Additional academic partnerships with the Courant Institute of New York University and Bard College provide students with a rich array of training opportunities. Rockefeller forges collaborations with biotech and pharmaceutical companies as needed to speed research findings into development to improve patient care.Clinical research hospital
In 1910, Rockefeller scientists founded the nation's first hospital devoted exclusively to experimental medicine. The Rockefeller University Hospital's only patients are participants in clinical trials building on basic research findings from Rockefeller labs. This "allows the university to maintain an unbroken spectrum of research, from basic to clinical," says Joshua Lederberg, Nobel laureate and Rockefeller president emeritus. Unburdened by constraints of standard patient care, the hospital is a vital component of Rockefeller's commitment to accelerating basic research findings on their route from bench to bedside for the diagnosis, treatment and prevention of disease. Studies are under way on AIDS/ HIV, obesity, hepatitis C and addictive diseases. More than science
Artistic and intellectual activity flourishes on Rockefeller's campus. The verdant grounds, situated on Manhattan's Upper East Side, boast a world-class art collection. The university regularly hosts events designed to explore the intuitive connection between science and the arts.Weekly and monthly recital series grace the university's spectacular auditorium, and a variety of exhibits regularly take shape on campus -currently including sculpture on temporary exhibition from New York's Museum of Modern Art. Select graduate student body
A class of Ph.D. and M.D.-Ph.D. students from across the United States and the world works closely with international faculty in a rigorous, highly personalized program of graduate study and research. The university offers graduate students access and opportunities to work with leading scientists, as well as full financial support and affordable on- and off-campus housing. University budget
Funding the research studies of The Rockefeller University's scientists are the National Institutes of Health and other government agencies, Howard Hughes Medical Institute, private gifts and endowment income.
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