Remote | Preclinical Drug Discovery & Development Scientist — $50–$90/hour

24-Mag

  • New York, New York
  • 5 days ago
  • Remote

    Highlights

    Selected experts will review scientific materials and development data, evaluate model outputs, contribute practical judgement on drug-development decisions, and help define high-quality data structures grounded in authentic preclinical workflows. This opportunity is best suited to hands-on drug-development professionals rather than backgrounds focused primarily on CRO/CDMO services, academic-only research, QC/analytical functions, clinical development, diagnostics, regulatory affairs, or medical writing.

    Numbers & Facts

    LocationNew York, New York (
    Remote
    )
    Website4-mag.com/privacy-policy

    Description

    We are sharing a specialised part-time consulting opportunity for experienced preclinical R&D professionals with hands-on industry experience advancing drug programmes from discovery toward the clinic.

    This role supports a research initiative focused on improving how advanced computational systems reason about real-world pharmaceutical R&D. Selected experts will review scientific materials and development data, evaluate model outputs, contribute practical judgement on drug-development decisions, and help define high-quality data structures grounded in authentic preclinical workflows.

    Key Responsibilities

    Preclinical R&D Review

    • Review technical materials and real-world scientific data from drug discovery and development workflows
    • Evaluate whether analyses and conclusions reflect realistic preclinical R&D practice
    • Identify missing assumptions, weak reasoning, and biologically or chemically implausible outputs
    • Apply hands-on industry judgement to complex scientific scenarios
    • Assess trade-offs across efficacy, safety, developability, and programme risk

    Scientific Data Evaluation

    • Label, classify, and annotate scientific data and model-generated outputs
    • Identify meaningful experimental signals, development decisions, and failure modes
    • Evaluate the quality and relevance of data used in downstream research workflows
    • Help establish consistent standards for scientific annotation and review
    • Translate practical R&D knowledge into structured, usable data

    Drug Discovery & Lead Optimisation

    • Apply experience across target selection, modality choice, hit-to-lead, and lead optimisation workflows
    • Evaluate decisions involving potency, selectivity, pharmacology, PK/PD, and developability
    • Review programme trade-offs and scientific risks
    • Assess whether proposed optimisation strategies reflect realistic drug-development constraints
    • Contribute expertise from programmes progressing toward IND-enabling development

    Modality-Specific Development

    • Apply hands-on experience with one or more therapeutic modalities, such as:
      • Small molecules
      • Monoclonal antibodies
      • Peptides
      • Antibody-drug conjugates
      • Bispecifics
      • mRNA
      • siRNA and ASOs
      • PROTACs and molecular glues
      • Cell therapies
      • Gene therapies
      • Radioligand therapies
    • Evaluate modality-specific scientific and development considerations
    • Identify challenges related to delivery, stability, efficacy, safety, or manufacturability

    Core R&D Functions

    • Contribute expertise from areas such as:
      • Discovery biology
      • Medicinal chemistry
      • Protein or antibody engineering
      • Computational drug discovery
      • In vivo and translational research
      • Pharmacology and PK/PD
      • Toxicology
      • CMC and formulation
    • Apply cross-functional judgement to development decisions
    • Evaluate how findings from different disciplines affect programme progression

    Dataset & Research Development

    • Help define structure and quality standards for scientific data pipelines
    • Identify which experimental signals and development decisions should be captured
    • Surface workflow details that are often missed outside hands-on industry R&D
    • Participate in expert discussions, interviews, and research engagements
    • Provide practical perspective on how preclinical drug-development teams operate

    Ideal Profile

    • 5+ years of relevant pharmaceutical or biotechnology R&D experience, with flexibility for candidates demonstrating exceptional depth
    • Hands-on, non-administrative preclinical R&D experience within a company developing its own therapeutic assets
    • Experience at an organisation that has advanced internal drug programmes toward or into clinical development
    • Current or recent work in a core R&D function such as discovery biology, medicinal chemistry, protein engineering, computational discovery, translational science, pharmacology, PK/PD, toxicology, or CMC
    • Hands-on experience with at least one therapeutic modality
    • Experience advancing a programme through lead optimisation, IND-enabling studies, or preclinical development is highly valued
    • Experience within mid-sized, emerging, or resource-constrained biotechnology environments is advantageous
    • Seniority may range from experienced individual contributor through Director level
    • Strong scientific judgement and ability to explain technical decisions clearly
    • This opportunity is best suited to hands-on drug-development professionals rather than backgrounds focused primarily on CRO/CDMO services, academic-only research, QC/analytical functions, clinical development, diagnostics, regulatory affairs, or medical writing

    Engagement Details

    • Part-time independent contractor engagement
    • Fully remote
    • Expected commitment of approximately 10 hours per week
    • Ongoing engagement based on project needs
    • Compensation: $50–$90/hour
    • Contributors will interact directly with the assigned research team
    • Projects may be extended, shortened, or concluded based on project needs and performance
    • Work must be completed without using confidential or proprietary information belonging to any employer, client, institution, or other third party
    • H1-B and STEM OPT support is unavailable for this engagement

    About the Platform

    This opportunity is available through 24-MAG LLC. We connect experienced professionals with remote consulting opportunities across technical, evaluation, and project-based workstreams.

    By submitting this application, you acknowledge that your information may be processed by 24-MAG LLC for recruitment and opportunity matching in accordance with our Privacy Policy: https://www.24-mag.com/privacy-policy.

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