Senior and Principal Applied Scientists - CoreAI MicrosoftSenior and Principal Applied Scientists - CoreAIMountain View, CA$119,800–$234,700 / yearBachelors Degree in Statistics, Econometrics, Computer Science, Electrical or Computer Engineering, or related field AND 9+ years related experience (e.g., statistics, predictive analytics, research)OR Masters Degree in Statistics, Econometrics, Computer Science, Electrical or Computer Engineering, or related field AND 6+ years related experience (e.g., statistics, predictive analytics, research). Bachelors Degree in Statistics, Econometrics, Computer Science, Electrical or Computer Engineering, or related field AND 4+ years related experience (e.g., statistics predictive analytics, research)OR Masters Degree in Statistics, Econometrics, Computer Science, Electrical or Computer Engineering, or related field AND 3+ years related experience (e.g., statistics, predictive analytics, research).
Principal Applied Scientist MicrosoftPrincipal Applied ScientistMountain View, CA$139,900–$274,800 / yearBachelors Degree in Statistics, Econometrics, Computer Science, Electrical or Computer Engineering, or related field AND 6+ years related experience (e.g., statistics, predictive analytics, research)OR Masters Degree in Statistics, Econometrics, Computer Science, Electrical or Computer Engineering, or related field AND 4+ years related experience (e.g., statistics, predictive analytics, research). Masters Degree in Statistics, Econometrics, Computer Science, Electrical or Computer Engineering, or related field AND 9+ years related experience (e.g., statistics, predictive analytics, research)OR Doctorate in Statistics, Econometrics, Computer Science, Electrical or Computer Engineering, or related field AND 6+ years related experience (e.g., statistics, predictive analytics, research).
Principal Data Scientist MicrosoftPrincipal Data ScientistMountain View, CA$139,900–$274,800 / yearDoctorate in Data Science, Mathematics, Statistics, Econometrics, Economics, Operations Research, Computer Science, or related field AND 5+ year(s) data-science experience (e.g., managing structured and unstructured data, applying statistical techniques and reporting results)OR Masters Degree in Data Science, Mathematics, Statistics, Econometrics, Economics, Operations Research, Computer Science, or related field AND 7+ years data-science experience (e.g., managing structured and unstructured data, applying statistical techniques and reporting results). OR Bachelors Degree in Data Science, Mathematics, Statistics, Econometrics, Economics, Operations Research, Computer Science, or related field AND 10+ years data-science experience (e.g., managing structured and unstructured data, applying statistical techniques and reporting results).
NewPrincipal Applied Scientist, ML Codesign Amazon.com Services LLCPrincipal Applied Scientist, ML CodesignSunnyvale, CAFamiliarity with Application-Specific Integrated Circuit (ASIC) development flow, Register Transfer Level (RTL) review, or compiler intermediate representations including Multi-Level Intermediate Representation (MLIR) and OpenXLA. • Eight or more years of industry experience with a track record of first-author or senior-author publications at top-tier venues in machine learning systems, computer architecture, or efficient machine learning.
Principal Applied Scientist, Experimentation Platform - CoreAI MicrosoftPrincipal Applied Scientist, Experimentation Platform - CoreAIMountain View, CA$139,900–$274,800 / yearBachelors Degree in Statistics, Econometrics, Computer Science, Electrical or Computer Engineering, or related field AND 6+ years related experience (e.g., statistics, predictive analytics, research) OR Masters Degree in Statistics, Econometrics, Computer Science, Electrical or Computer Engineering, or related field AND 4+ years related experience (e.g., statistics, predictive analytics, research) OR Doctorate in Statistics, Econometrics, Computer Science, Electrical or Computer Engineering, or related field AND 3+ years related experience (e.g., statistics, predictive analytics, research) OR equivalent experience. Proven track record designing and scaling online experimentation platforms that support high‑velocity A/B and multivariate testing across complex, multi‑team product ecosystems, including governance, guardrails, and causal inference best practices.
Principal Data Scientist & Analytics MicrosoftPrincipal Data Scientist & AnalyticsMountain View, CA$139,900–$274,800 / yearDoctorate in Data Science, Mathematics, Statistics, Econometrics, Economics, Operations Research, Computer Science, or related field AND 8+ years data-science experience (e.g., managing structured and unstructured data, applying statistical techniques and reporting results)OR Masters Degree in Data Science, Mathematics, Statistics, Econometrics, Economics, Operations Research, Computer Science, or related field AND 10+ years data-science experience (e.g., managing structured and unstructured data, applying statistical techniques and reporting results). Doctorate in Data Science, Mathematics, Statistics, Econometrics, Economics, Operations Research, Computer Science, or related field AND 5+ years data-science experience (e.g., managing structured and unstructured data, applying statistical techniques and reporting results)OR Masters Degree in Data Science, Mathematics, Statistics, Econometrics, Economics, Operations Research, Computer Science, or related field AND 7+ years data-science experience (e.g., managing structured and unstructured data, applying statistical techniques and reporting results).
NewPrincipal Mechanical Engineer JobotPrincipal Mechanical EngineerMountain View, CA$200,000–$260,000 / yearInformation collected and processed as part of your Jobot candidate profile, and any job applications, resumes, or other information you choose to submit is subject to Jobot's Privacy Policy, as well as the Jobot California Worker Privacy Notice and Jobot Notice Regarding Automated Employment Decision Tools which are available at jobot.com/legal. Founded by industry veterans from leading aerospace and satellite organizations, the company has rapidly grown into a team of over 200 engineers, scientists, and innovators focused on building next-generation space infrastructure.
NewSenior Principal Engineer- End-to-End AI Training Framework Bosch Group IncSenior Principal Engineer- End-to-End AI Training FrameworkSunnyvale, CA$240,000–$320,000 / yearAs the Senior Principal Engineer, E2E AI Training Framework for Autonomous Driving Systems, you will spearhead the development and optimization of the machinery that efficiently trains, optimizes, tests, and releases various E2E AI-based products (e.g. The ideal candidate must have prior industry experience in releasing AI-based L2+ systems, with a proven track record of translating innovative research into production-grade solutions.
NewStaff Machine Learning Engineer (Research Scientist) - DFAI PlaidStaff Machine Learning Engineer (Research Scientist) - DFAISan Francisco, CA$249,120–$367,920 / yearPhD: 5–9+ years of industry experience with evidence of technical leadership (tech lead, principal/staff-equivalent roles) and end-to-end production ownership. We work with thousands of companies like Venmo, SoFi, several of the Fortune 500, and many of the largest banks to make it easy for people to connect their financial accounts to the apps and services they want to use.
Principal Technical Program Manager MicrosoftPrincipal Technical Program ManagerMountain View, CA$139,900–$274,800 / yearThere is a different range applicable to specific work locations, within the San Francisco Bay area and New York City metropolitan area, and the base pay range for this role in those locations is USD $188,000 - $304,200 per year. This role is designed for a senior individual contributor (Principal Technical Program Manager) who thrives in highly ambiguous, data‑rich environments and is motivated by solving complex, high‑impact problems at scale.
Principal Software Engineer - Responsible AI (CoreAI) MicrosoftPrincipal Software Engineer - Responsible AI (CoreAI)Mountain View, CA$139,900–$274,800 / yearThere is a different range applicable to specific work locations, within the San Francisco Bay area and New York City metropolitan area, and the base pay range for this role in those locations is USD $188,000 - $304,200 per year. Bachelors Degree in Computer Science or related technical field AND 6+ years technical engineering experience with coding in languages including, but not limited to, C, C++, C#, Java, JavaScript, Go, or PythonOR equivalent experience.
Principal, Data Science & Analytics MicrosoftPrincipal, Data Science & AnalyticsMountain View, CA$139,900–$274,800 / yearDoctorate in Data Science, Mathematics, Statistics, Econometrics, Economics, Operations Research, Computer Science, or related field AND 8+ years data-science experience (e.g., managing structured and unstructured data, applying statistical techniques and reporting results)OR Masters Degree in Data Science, Mathematics, Statistics, Econometrics, Economics, Operations Research, Computer Science, or related field AND 10+ years data-science experience (e.g., managing structured and unstructured data, applying statistical techniques and reporting results). Doctorate in Data Science, Mathematics, Statistics, Econometrics, Economics, Operations Research, Computer Science, or related field AND 5+ years data-science experience (e.g., managing structured and unstructured data, applying statistical techniques and reporting results)OR Masters Degree in Data Science, Mathematics, Statistics, Econometrics, Economics, Operations Research, Computer Science, or related field AND 7+ years data-science experience (e.g., managing structured and unstructured data, applying statistical techniques and reporting results).
Principal Software Engineer MicrosoftPrincipal Software EngineerMountain View, CA$139,900–$274,800 / yearMasters Degree in Computer Science or related technical field AND 8+ years technical engineering experience with coding in languages including, but not limited to, C, C++, C#, Java, JavaScript, or Python OR Bachelors Degree in Computer Science or related technical field AND 12+ years technical engineering experience with coding in languages including, but not limited to, C, C++, C#, Java, JavaScript, or Python OR equivalent experience. There is a different range applicable to specific work locations, within the San Francisco Bay area and New York City metropolitan area, and the base pay range for this role in those locations is USD $188,000 - $304,200 per year.
Principal Machine Learning Engineer, Mobile AI Inference Optimization Unity SoftwarePrincipal Machine Learning Engineer, Mobile AI Inference OptimizationMountain View, CAWhile specific benefits vary, here are some of the ways we strive to take care of our eligible team members globally: Comprehensive health, life, and disability insurance | Commute subsidy | Employee stock ownership | Competitive retirement/pension plans | Generous vacation and personal days | Support for new parents through leave and family-care programs | Office food snacks | Mental Health and Wellbeing programs and support | Employee Resource Groups | Global Employee Assistance Program | Training and development programs | Volunteering and donation matching program. As our Principal Machine Learning Engineer, you will be the foremost technical authority on bringing state-of-the-art multi-modal models (transformers, diffusion networks, and JAPE-style architectures) from research to production on mobile hardware.
Principal Software Engineer, Experimentation Platform - CoreAI MicrosoftPrincipal Software Engineer, Experimentation Platform - CoreAIMountain View, CA$139,900–$274,800 / yearMaster’s Degree in Computer Science or related technical field AND 8+ years technical engineering experience with coding in languages including, but not limited to, C, C++, C#, Java, JavaScript, or Python OR Bachelor’s Degree in Computer Science or related technical field AND 12+ years technical engineering experience with coding in languages including, but not limited to, C, C++, C#, Java, JavaScript, or Python OR equivalent experience. Lead cross-team collaboration to identify dependencies, negotiate delivery schedules, drive alignment across partner teams, and ensure proper end-to-end testing, live-site coverage, scalability and performance before going live.
Principal/Senior Software Engineer, Experimentation Platform - CoreAI MicrosoftPrincipal/Senior Software Engineer, Experimentation Platform - CoreAIMountain View, CA$119,800–$234,700 / yearMaster’s Degree in Computer Science or related technical field AND 6+ years technical engineering experience with coding in languages including, but not limited to, C, C++, C#, Java, JavaScript, or Python OR Bachelor’s Degree in Computer Science or related technical field AND 8+ years technical engineering experience with coding in languages including, but not limited to, C, C++, C#, Java, JavaScript, or Python OR equivalent experience. There is a different range applicable to specific work locations, within the San Francisco Bay area and New York City metropolitan area, and the base pay range for this role in those locations is USD $158,400 - $258,000 per year.
Principal Software Engineer, Ads Infrastructure Unity SoftwarePrincipal Software Engineer, Ads InfrastructureSan Francisco, CAWhile specific benefits vary, here are some of the ways we strive to take care of our eligible team members globally: Comprehensive health, life, and disability insurance | Commute subsidy | Employee stock ownership | Competitive retirement/pension plans | Generous vacation and personal days | Support for new parents through leave and family-care programs | Office food snacks | Mental Health and Wellbeing programs and support | Employee Resource Groups | Global Employee Assistance Program | Training and development programs | Volunteering and donation matching program. The platform is built on technologies such as Kubernetes, Kafka, Flink, Starrocks, Valkey, and other cloud native components, and supports the engineers, data scientists, and product teams that drive Unity Ads forward.
Senior Software Engineer - Responsible AI (CoreAI) MicrosoftSenior Software Engineer - Responsible AI (CoreAI)Mountain View, CA$119,800–$234,700 / yearThere is a different range applicable to specific work locations, within the San Francisco Bay area and New York City metropolitan area, and the base pay range for this role in those locations is USD $158,400 - $258,000 per year. We are looking for a Principal Software Engineer - Responsible AI who is passionate about building customer-facing AI services with scalable and sustainable architecture and implementation and with high performance, low latency, and high availability.
NewSenior Scientist / Principal Scientist, Complex in Vitro Systems Genentech IncSenior Scientist / Principal Scientist, Complex in Vitro SystemsSouth San Francisco, CA$120,700–$224,100 / yearResponsibilities include culturing and characterizing state-of-the-art ocular CIVM models, designing and executing model qualification and characterization studies (e.g., advanced imaging, transcriptomics, and functional and phenotypic assays), analyzing and interpreting complex datasets; and maintaining rigorous, high-quality documentation. The Position: The Complex in Vitro Systems (CiS) Lab within the Department of Translational Safety is seeking a highly motivated Senior Scientist / Principal Scientist to develop, characterize, and qualify advanced complex in vitro models to support Genentech's mission of delivering safe and efficacious medicines.
Sr Scientist/ Associate Principal Scientist, LCMS Platforms CRYSTAL PHARMATECH INCSr Scientist/ Associate Principal Scientist, LCMS PlatformsPleasanton, CA$120,000–$165,000 / yearIndependently propose assay design and/or strategy, develop, validate, conduct, and troubleshoot LCMS-based bioanalytical methods for the quantification of small molecule (and its metabolites) and biologics (e.g. The Bioanalysis & Biomarkers Department specializes in Method Development, Method Validation, GLP/GCLP Bioanalysis for PK, and biomarkers.
Senior/Principal Machine Learning Scientist, Structure and Simulation (AI for Drug Discovery) Genentech IncSenior/Principal Machine Learning Scientist, Structure and Simulation (AI for Drug Discovery)South San Francisco, CA$147,800–$274,400 / yearIn this role, you will: As a Senior Scientist: • Develop novel machine learning methods to answer challenging research questions in large molecule drug discovery • Work with biological and chemical data from heterogeneous sources • Contribute to an initiative to consolidate projects in machine learning theory into a single coherent model for lab-in-the-loop drug discovery. As a Principal Scientist: • Develop novel machine learning methods to answer challenging research questions in large molecule drug discovery • Work with biological and chemical data from heterogeneous sources • Lead an initiative to consolidate projects in machine learning theory into a single coherent model for lab-in-the-loop drug discovery.
Principal/Sr. Principal Scientist - Development Genentech IncPrincipal/Sr. Principal Scientist - DevelopmentSouth San Francisco, CA$141,500–$262,900 / yearThe successful candidate for Principal/Sr Principal Scientist will provide scientific leadership and play an active role in the process of drug development, with a strong emphasis on Genentech's oncology and cardiovascular, respiratory, and metabolism development project portfolio, which includes small molecules, immunomodulatory biotherapeutics, bi-specific antibodies, ADCs, cancer vaccines and cellular therapeutics. Working in a collaborative team environment, the Principal/Sr Principal Scientist leads the safety assessment of Genentech therapeutics by creating a best-evidence synthesis of existing knowledge and comprehensive investigations of toxicologic activity, strategic planning, and designing/implementing/supervising toxicology studies in support of program advancement.
Sr Scientist/ Associate Principal Scientist, LCMS Platforms Crystal PharmatechSr Scientist/ Associate Principal Scientist, LCMS PlatformsPleasanton, CaliforniaOur guiding principle of "getting the crystal form and formulation right the first time for Phase I" not only expedites the progression of your molecule to IND filing and Phase I clinical trials, but also minimizes the necessity for human PK bridging studies. Independently propose assay design and/or strategy, develop, validate, conduct, and troubleshoot LCMS-based bioanalytical methods for the quantification of small molecule (and its metabolites) and biologics (e.g.
Senior / Principal Machine Learning Scientist, Scientific Reasoning Models, AI for Drug Discovery Genentech IncSenior / Principal Machine Learning Scientist, Scientific Reasoning Models, AI for Drug DiscoverySouth San Francisco, CA$167,400–$310,800 / yearThe new Computational Sciences Center of Excellence (CoE) is a strategic, unified group whose goal is to harness the transformative power of data and Artificial Intelligence (AI) to assist our scientists in both pRED and gRED to deliver more innovative and transformative medicines for patients worldwide. Research-to-Production Impact: Partner with researchers and cross-functional teams to move models from research prototypes to production-ready systems that support active discovery programs.
Senior Scientist or Associate Principal Scientist, LBA Platforms CRYSTAL PHARMATECH INCSenior Scientist or Associate Principal Scientist, LBA PlatformsPleasanton, CAThe Bioanalysis & Biomarkers Department specializes in Method Development, Method Validation, GLP/GCLP Bioanalysis for PK, immunogenicity and biomarkers. The role is responsible for providing bioanalytical support for both pre-clinical and clinical projects and partnering with our clients for project success.
Senior/Principal AI/ML Computational Scientist Genentech IncSenior/Principal AI/ML Computational ScientistSouth San Francisco, CA$156,200–$290,200 / yearWho You Are: PhD in biomedical engineering, bioengineering, computer science, computational biology, bioinformatics, data science, statistics, computer vision, image analysis, or a related quantitative discipline; Senior Scientist level (0-2 years) Principal Scientist (3+ years of experience). Our work focuses on extracting quantitative, reproducible, and biologically meaningful information from digital histopathology images and related imaging datasets to support preclinical safety assessment, mechanistic investigation, and translational research.
Senior / Principal Scientist, AI for Protein Engineering Lila SciencesSenior / Principal Scientist, AI for Protein EngineeringSan Francisco, CaliforniaWithin Life Sciences AI (LSAI), the AI for Protein Engineering team develops and uses the generative and predictive models that drive Lila's biomolecule design programs from in silico hypothesis to wet-lab validated lead. Full-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program.
Senior / Principal Scientist, Foundation Models for life Sciences Lila Sciences IncSenior / Principal Scientist, Foundation Models for life SciencesSan Francisco, CA$288,000–$480,000 / yearFull-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program. LILA combines advanced AI models with proprietary AI Science Factory instruments into an operating system for science that executes the entire scientific method autonomously, accelerating discovery at unprecedented speed, scale, and impact across medicine, materials, and energy.
Senior / Principal Scientist, AI for Protein Engineering Lila Sciences IncSenior / Principal Scientist, AI for Protein EngineeringSan Francisco, CA$268,000–$358,000 / yearWithin Life Sciences AI (LSAI), the AI for Protein Engineering team develops and uses the generative and predictive models that drive Lila's biomolecule design programs from in silico hypothesis to wet-lab validated lead. Full-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program.
Senior Principal Scientist, Cardiovascular, Translational Development Bristol-Myers Squibb CoSenior Principal Scientist, Cardiovascular, Translational DevelopmentBrisbane, CAKeeps up-to-date on relevant scientific/technical literature in order to applying external knowledge to internal research programs as appropriate and acts as a subject-matter expert within the team to critically evaluate the literature regarding the asset and disease biology Keeps up-to-date on relevant scientific/technical literature in order to applying external knowledge to internal research programs as appropriate and acts as a subject-matter expert within the team to critically evaluate the literature regarding the asset and disease biology. • Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays.
Principal Scientist, Pharmacokinetics Merck & Co IncPrincipal Scientist, PharmacokineticsSouth San Francisco, CA$176,200–$277,300 / yearRequired Skills: ADME, Biochemical Analysis, Biophysics, Cross-Functional Teamwork, Detail-Oriented, Diversity and Inclusion (D&I), Drug Metabolism, Immunoassays, Innovation, Liquid Chromatography-Mass Spectrometry (LC-MS), Mentoring Staff, Pharmaceutical Sciences, Pharmacodynamics, Pharmacokinetics, PKPD Modeling, Therapeutic Proteins. Key Responsibilities of the Principal Scientist: Project-team representative and subject matter expert for biologics drug discovery and development, including but not limited to drug conjugates, multi-specific biologics, and novel modalities.
NewPrincipal Scientist, Global Patient Safety Surveillance Revolution MedicinesPrincipal Scientist, Global Patient Safety SurveillanceRedwood City, CaliforniaServe as the lead principal subject matter expert for the design, development, maintenance, and support of one or more core GPS processes (i.e. comparative benefit-risk, signal detection & management, risk management, aggregate reporting, etc.) in compliance with applicable Good Clinical Practice (GCP), Good Pharmacovigilance Practice (GVP), Good Documentation Practices (GDocP), etc., in alignment with the company’s mission and objectives. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development.
NewPrincipal Scientist, Global Patient Safety Surveillance Revolution Medicines IncPrincipal Scientist, Global Patient Safety SurveillanceRedwood City, CA$211,000–$264,000 / yearResponsibilities include: Serve as the lead principal subject matter expert for the design, development, maintenance, and support of one or more core GPS processes (i.e. comparative benefit-risk, signal detection & management, risk management, aggregate reporting, etc.) in compliance with applicable Good Clinical Practice (GCP), Good Pharmacovigilance Practice (GVP), Good Documentation Practices (GDocP), etc., in alignment with the company's mission and objectives. The company's RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development.
Principal / Sr. Principal BioML Scientist Lila SciencesPrincipal / Sr. Principal BioML ScientistSan Francisco, CaliforniaCo-architect the AI-for-Cell-Biology platform's scientific direction, partnering with the AI/ML Science and Engineering leads to shape how AI, lab automation, and closed-loop experimentation together change how cell biology is done — what closed loops to run, what cycle times and evidence thresholds matter, what kinds of scientific questions become tractable that weren't before. Shape the team's evaluation framework and scientific bar alongside research and engineering leads by owning what makes a benchmark biologically meaningful, what evidence threshold turns a model output into an experimental decision, and what counts as the platform delivering real new science rather than just well-scored predictions.
Senior Scientist or Associate Principal Scientist, LBA Platforms Crystal PharmatechSenior Scientist or Associate Principal Scientist, LBA PlatformsPleasanton, CaliforniaOur guiding principle of "getting the crystal form and formulation right the first time for Phase I" not only expedites the progression of your molecule to IND filing and Phase I clinical trials, but also minimizes the necessity for human PK bridging studies. Our key differentiator is our integrated and specialized services, including API solid-state research, crystallization, preformulation, formulation development and manufacturing, clinical supply.
Senior/Principal Scientist SonoThera IncSenior/Principal ScientistSouth San Francisco, CA$150,000–$206,000 / yearTechnical Requirements & Skills: Demonstrated success in developing potent and safe gene therapy payloads for both viral and non-viral delivery, evidenced by first authorship in peer-reviewed publications, patents, and presentations at major international gene therapy conferences. Work in close connection with project management team and manage vector development activities, leveraging advanced project management tools such as SmartSheet to ensure accurate timelines, resource allocation, and milestone delivery.
Principal / Sr. Principal BioML Scientist Lila Sciences IncPrincipal / Sr. Principal BioML ScientistSan Francisco, CA$288,000–$480,000 / yearCo-architect the AI-for-Cell-Biology platform''s scientific direction, partnering with the AI/ML Science and Engineering leads to shape how AI, lab automation, and closed-loop experimentation together change how cell biology is done - what closed loops to run, what cycle times and evidence thresholds matter, what kinds of scientific questions become tractable that weren''t before. Shape the team''s evaluation framework and scientific bar alongside research and engineering leads by owning what makes a benchmark biologically meaningful, what evidence threshold turns a model output into an experimental decision, and what counts as the platform delivering real new science rather than just well-scored predictions.
Principal Scientist, Protein Engineering Merck & Co IncPrincipal Scientist, Protein EngineeringSouth San Francisco, CA$176,200–$277,300 / yearPhD in Protein Engineering, Biochemistry, Biology, Biophysics, Biotechnology, Bioengineering, Immunology, Pharmaceutical Sciences, Chemistry, Computational Protein Design, or related STEM field with 8+ years of applied experience, or an MS and 10+ year of applied experience or a B.S. and 14+ years of applied experience. Work closely with HT protein engineering and computational protein engineers to integrate augmented designs and computational approaches toward accelerated derisking and optimization of biologics for best-in-class and first-in-class therapeutics.
Associate Principal Scientist, Respiratory Discovery Merck & Co IncAssociate Principal Scientist, Respiratory DiscoverySouth San Francisco, CA$159,600–$251,200 / yearThis role is suited for a highly independent scientist who can design and execute complex studies, generate high-quality scientific insights, and contribute effectively to cross-functional project teams within a matrixed drug discovery environment.m. Required Skills: Drug Target Identification, Ex Vivo, In Vitro Studies, Program Leadership, Pulmonary Disorders, Respiratory Diseases Prevention, Respiratory Diseases Treatment, Respiratory Pharmacology, Target Validation.
Associate Principal Scientist, In Vivo Pharmacology Merck & Co IncAssociate Principal Scientist, In Vivo PharmacologySouth San Francisco, CA$159,600–$251,200 / yearCollaborate with cross-functional groups (Biology, Med Chem, DMPK, Safety, etc.) to enable a comprehensive pharmacology strategy that enables robust assessment of target engagement, in vitro/in vivo correlation, PK/PD relationship, and human dose projection. Required Experience and Skills: Quantitative and translational pharmacology expertise with a solid understanding of key pharmacology concepts including target occupancy, in vitro/in vivo correlation, PK/PD, translational biomarker, and methods for human does projection.
Associate Principal Scientist, Discovery Oncology Merck & Co IncAssociate Principal Scientist, Discovery OncologySouth San Francisco, CA$159,600–$251,200 / yearRequired Skills: Biochemistry, Cancer Cell Biology, Cancer Research, Cell Biology, Immuno-Oncology, In Vitro Biology, In Vitro Research, In Vitro Studies, Molecular Biology, Oncology, Tumor Biology. Extensive hands-on in vitro experience designing, executing, and analyzing multi-color flow cytometry and mechanistic cell-based assays (e.g., viability/cytotoxicity, cell cycle, signaling, and immune response readouts).
Principal Scientist, Drug Product Process Science Allogene Therapeutics IncPrincipal Scientist, Drug Product Process ScienceSouth San Francisco, CA$155,000–$180,000 / yearThe successful candidate will play a critical role in drug product process characterization and BLA readiness for allogeneic CAR-T therapies, including but not limited to process characterization design and execution, and regulatory‑ready documentation in support of BLA‑enabling and BLA submission activities, and will work closely with cross‑functional partners across MSAT, Quality, Regulatory, Analytical Sciences, and Clinical Operations. Experience working in the pharmaceutical or biotechnology industry that includes elements of new product development, process characterization, formulation development, equipment design and implementation, technology transfers, statistical process control (SPC), and statistical design and analysis of experiments.
NewPrincipal Scientist, Drug Product Process Science Allogene TherapeuticsPrincipal Scientist, Drug Product Process ScienceSouth San Francisco, CA$155,000–$180,000 / yearThe successful candidate will play a critical role in drug product process characterization and BLA readiness for allogeneic CAR-T therapies, including but not limited to process characterization design and execution, and regulatory‑ready documentation in support of BLA‑enabling and BLA submission activities, and will work closely with cross‑functional partners across MSAT, Quality, Regulatory, Analytical Sciences, and Clinical Operations. Experience working in the pharmaceutical or biotechnology industry that includes elements of new product development, process characterization, formulation development, equipment design and implementation, technology transfers, statistical process control (SPC), and statistical design and analysis of experiments.
Associate Principal Scientist, Clinical Research Merck & Co IncAssociate Principal Scientist, Clinical ResearchSouth San Francisco, CA$142,400–$224,100 / yearTranslational Medicine (TMed) drives early clinical development of novel therapeutics by partnering with Discovery Sciences and Late-Stage Clinical Research to translate scientific discoveries into human proof-of-concept and advance the most promising candidates through the pipeline to patients. Leads and directs teams through key study planning, development, and execution activities, including program overviews, issue escalation and mitigation, senior management presentations, cross-functional governance meetings, and advisory meeting preparation.
Principal Scientist, Bioinformatics Nkarta, Inc.Principal Scientist, BioinformaticsSouth San Francisco, CA$180,000–$215,000 / yearA central focus of this role is to drive and execute on Nkarta's strategy for single-cell and spatial transcriptomics, leveraging scRNA-seq, spatial, and functional genomics approaches to drive translational insights, biomarker development, and clinical decision-making in early development. Nkarta is a publicly traded (Nasdaq symbol NKTX), clinical-stage biotechnology company headquartered in South San Francisco, focused on advancing the development of allogeneic, off-the-shelf natural killer (NK) cell therapies to treat autoimmune disease.
Principal Applied Scientist ADOBE IncPrincipal Applied ScientistSan Jose, CA$268,000–$388,000 / yearAdobe's industry-leading offerings including Adobe Acrobat Studio, Adobe Express, Adobe Firefly, Creative Cloud, Adobe Experience Platform, Adobe Experience Manager, and GenStudio enable people and businesses to turn ideas into impact, powered by AI and driven by human ingenuity. Learn more about Adobe life, including our values and culture, focus on people, purpose and community, Adobe for All, comprehensive benefits programs, the stories we tell, the customers we serve, and how you can help us advance our mission of empowering everyone to create.
Sr. Principal Scientist, Clinical Operations Immunology Lead Merck & Co IncSr. Principal Scientist, Clinical Operations Immunology LeadSouth San Francisco, CA$210,400–$331,100 / yearIn a competitive external landscape and fast-paced internal environment, the Immunology Clinical Operations Lead position provides both strategic and operational leadership across early immunology programs, ensuring timely, high-quality execution of clinical studies and clinical pharmacology strategies worldwide. Translational Medicine (TMed) drives early clinical development of novel therapeutics by partnering with Discovery Sciences and Late-Stage Clinical Research to translate scientific discoveries into human proof-of-concept and advance the most promising candidates through the pipeline to patients.
Principal Scientist, Analytical Development Sana Biotechnology IncPrincipal Scientist, Analytical DevelopmentSouth San Francisco, CA$200,000–$240,000 / yearPhysical Demands: Employees in this position may be required to perform the following physical activities: standing, walking, and sitting for extended periods of time; frequent use of the hands, fingers, wrist, and greater arm to handle small materials, tools, boxes, and trays; lifting and carrying objects up to 10 Ibs; occasional overhead reaches and lifts; occasional lifts and reaches below the knee; occasional pushing and pulling of materials and objects with moderate forces; occasional crouching/kneeling, twisting, and squatting movements. Act as a key contributor in developing and qualifying pivotal stage potency, immunoassay, and other cell-based methods to support the characterization, process development, release testing, and stability testing of cell therapy products.
Principal Scientist - Agentic Product ADOBE IncPrincipal Scientist - Agentic ProductCA$248,900–$360,500 / yearDeep, hands-on expertise with large language models - including practical fluency with LLM APIs, prompt engineering at scale, fine-tuning and RLHF concepts, context window management, retrieval-augmented generation, and the operational realities of running LLM-backed systems in production. Adobe's industry-leading offerings including Adobe Acrobat Studio, Adobe Express, Adobe Firefly, Creative Cloud, Adobe Experience Platform, Adobe Experience Manager, and GenStudio enable people and businesses to turn ideas into impact, powered by AI and driven by human ingenuity.