Sr. Manager, Accounts Payable

Overview

Alnylam Pharmaceuticals is seeking a Senior Manager, Accounts Payable to lead key aspects of our global, multi‑entity Procure‑to‑Pay operations. Reporting to the Global Process Owner, P2P, this role ensures timely, accurate, and well‑controlled Accounts Payable processes while advancing automation, process improvements, and strong customer service. The ideal candidate brings AP operational expertise, a process‑focused mindset, and a collaborative approach to strengthening controls and enhancing the end‑to‑end P2P experience. As a people leader, the role emphasizes clear communication, thoughtful development, and building team capability while fostering a supportive and accountable environment. This position partners widely across Finance and the business and contributes to ongoing P2P transformation and technology initiatives.

This is a hybrid position and will be primarily based in Cambridge, MA.

Responsibilities

• Lead and develop the AP team to deliver high‑quality, timely, and accurate processing across global entities.
• Oversee daily Invoice to Pay activities, including invoice validation, exception resolution, vendor payments, and AP service request management.
• Monitor performance through KPIs and analytics to identify trends and drive improvements in efficiency, transparency, and service delivery.
• Partner with technical teams to enhance tools, expand automation, and support ERP or P2P‑related system initiatives.
• Maintain strong internal controls and support SOX, fraud, and risk‑mitigation activities.
• Partner closely with Procurement and other P2P stakeholders to align processes and support consistent policy application.
• Collaborate with Accounting, IT, Treasury, Audit, Operations, and Legal to support smooth end‑to‑end business operations.
• Manage AP month‑end activities, including accruals, reconciliations, and vendor aging reviews.
• Provide clear communications and updates to stakeholders on operations, process recommendations, and improvement efforts.
• Support the scalability and continuous improvement of AP processes as the business grows.
• Ensure compliance with AP policies, accounting standards, and regulatory requirements such as 1099 reporting.

Qualifications

• Bachelor's degree in accounting, finance, business, or related field, or equivalent experience.
• 7+ years of relevant experience, including 3+ years leading a global or geographically dispersed AP team.
• Strong understanding of end‑to‑end P2P processes and multi‑entity AP operations.
• Demonstrated experience using automation, analytics, and process improvement to enhance AP efficiency and controls.
• Experience with enterprise financial systems and tools (SAP S/4HANA, Ariba, OpenText VIM preferred).
• Strong communication and relationship‑building skills with both internal and external stakeholders.
• Experience supporting SOX, fraud mitigation, or other control‑related activities within AP.
• Ability to manage multiple priorities in a fast‑paced environment while maintaining accuracy and service levels.
• Background supporting or contributing to vendor master data processes is an advantage.
• Ability to support scalable processes as AP volumes and global operations expand.

About Alnylam

We are the leader in RNAi therapeutics - a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Before applying, please review Alnylam's Candidate Privacy Notice regarding how Alnylam handles Personal Data you provide with your application for employment.

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