SENIOR SCIENTIST - IMMUNOBIOLOGY
JOB SUMMARY
The Immunobiology group is seeking a 6-month contracted Senior Scientist to support product development of novel protein therapeutics for oncology indications by characterizing the biologic activity of molecules using in vitro and in vivo experimental approaches. The focus of this position will be to lead the design, planning, execution and documentation of humanized in vivo experiments to study the efficacy and mechanism of action for investigational therapeutics.
Candidates must have extensive knowledge and expertise in immunology and a solid understanding of oncology, a track record of driving scientific projects independently and coordinating across functional teams.
RESPONSIBILITIES
- Design and conduct humanized in vivo models for the evaluation of lead bispecific and multispecific molecules for oncology (solid tumor) indications
- Oversee and implement all aspects of efficacy studies utilizing rodent cancer models
- Culturing of mammalian tumor cells
- Subcutaneous and orthotopic implantation of tumor cell xenografts into mice
- Compound dosing by all routes, followed by blood and tissue collection measurements of tumor burden and metastatic growth and incidence
- In vivo imaging studies to follow tumor burden and determine efficacy
- Perform ex vivo efficacy studies utilizing human normal and tumor samples
- Evaluate in vitro activity of antibodies, bispecific and multispecific molecules against oncology targets of interest
- Investigate the mechanism of action and toxicity for bispecific and multispecific molecules
- Ex vivo analysis of cells isolated from in vivo studies to assess mechanism of action
- Preparing scientific communication and documentation such as protocols and reports
- Assist in the selection and management of academic collaborations and Contract Research Organizations
- Work closely with project teams, providing pre-clinical data to support IND-enabling activities
EDUCATION, EXPERIENCE & SKILLS
- PhD in biological scientific and 5+ years relevant experience (may include a postdoc), or an MS/MA degree and 13+ years of experience, or a BS/BA degree and 15+ years of experience
- Minimum 5 years hands on experience in designing and executing in vivo cancer model experiments including proficiency with cancer disease models, transgenic and KO approaches, orthotopic implantation and imaging techniques
- Strong working knowledge of molecular therapeutic approaches in oncology
- Cross-functional team experience
- Expertise with all levels of animal handling, including dosing, bleeding / surgical skills/ tissue procurement and processing
- Experience with IACUC
- Experience with cellular and protein immunoassay technologies (multi-parameter FACS, multiplex cytokines)
- Experience with in vitro cytotoxic assays (proliferation, Incucyte)
- Proficiency in the use of software tools to support data analysis (Prism, FlowJo, Microsoft suite)
- Excellent organization and communication skills including accurate records, verbal presentation of work and interaction with collaborators and vendors
- Ability to multi-task across experiments and projects
- Ability for independent thinking and strongly self-motivated
- Equivalent education, experience and skills may substitute for stated requirements
SALARY RANGE: $136,690 - 190,711
Compensation will be determined based on the candidate's qualifications, relevant experience, skills, and overall fit for the position.
EMPLOYEE BENEFITS (for Regular, non-Temporary/non-Contract Employees)
- Generous paid time off (PTO) program
- 9 paid holidays + paid time off between Christmas and New Year's Day
- Medical, dental insurance for employees and eligible dependent(s) - PPO & High-Deductible Plan
- Vision plan
- Health Savings Account (HSA) with employer funding: single: $500, family: $1,000
- Flexible Spending Account (FSA)
- Health Care Flexible Spending Account
- Dependent Care Flexible Spending Account
- Equity award eligibility
- Annual bonus plan eligibility
- 401(k) & Roth Plan: $.50 match for every dollar contributed to a maximum of 3%
- Basic life and AD&D insurance: company paid
- Long-term disability: company paid
- Shor-term disability: company paid
- Supplemental Life and AD&D for employee, spouse and child(ren)
- Employee Referral Bonus Program
- Employee Assistance Plan (EAP)
- Paid parental leave
- Tuition reimbursement program