| Location | Ridgefield, CT |
Location: Ridgefield, CT
Duration: 12 Months
Company: Sigma Systems
Job Type: Contract
Sigma Systems is seeking an experienced Scientist III to support scientific research and drug discovery activities in Ridgefield, Connecticut. This role is ideal for a non-PhD scientist with a strong background in mammalian cell culture, molecular biology, cell-based assays, and biochemical techniques within a pharmaceutical, biotechnology, or contract research organization (CRO) environment.
The successful candidate will independently design and execute in vitro experiments, analyze and interpret scientific data, troubleshoot experimental challenges, and contribute to research initiatives in a highly collaborative laboratory environment.
Weekend Commitment: Approximately 2–4 hours each weekend to support business operations. Scheduling is flexible and can typically be completed at a time that works best for the employee.
Independently initiate, design, and execute routine in vitro studies and cell-based experiments in a timely and efficient manner.
Analyze experimental results, interpret scientific data, troubleshoot issues, and recommend appropriate follow-up experiments.
Design and perform non-routine cell-based and biochemical assays using scientific literature, published protocols, and established research methods.
Perform mammalian cell culture and aseptic laboratory techniques while maintaining consistent experimental quality.
Execute molecular biology procedures, including nucleic acid extraction, RT-PCR, Western blotting, ELISA, and transfection.
Conduct literature searches to identify relevant scientific information, evaluate emerging technologies, and support research innovation.
Operate, maintain, and troubleshoot laboratory instruments and equipment independently.
Develop experimental approaches that support drug discovery and development objectives.
Maintain accurate electronic laboratory notebooks, experimental records, and research documentation.
Prepare and contribute to technical reports, scientific reports, laboratory protocols, and standard operating procedures (SOPs).
Communicate experimental findings clearly and accurately to research teams and department leadership.
Support the training and development of laboratory technicians and junior scientists.
Maintain data integrity and comply with applicable laboratory safety requirements, regulations, and established procedures.
Master’s degree with at least 3 years of relevant experience, or Bachelor’s degree with at least 7 years of relevant experience, or equivalent experience in a related scientific discipline.
Non-PhD candidate required.
Experience in pharmaceutical, biotechnology, or CRO environments is highly desirable.
Hands-on experience with aseptic mammalian cell culture and in vitro experimental techniques.
Strong working knowledge of basic molecular biology techniques, including:
Nucleic acid extraction
RT-PCR
Western blot
ELISA
Transfection
Ability to independently operate laboratory equipment and troubleshoot experimental procedures.
Experience designing experiments, executing protocols, interpreting results, and reporting technical data.
Proficiency in Microsoft Excel and scientific data analysis software such as GraphPad Prism.
Strong written and verbal communication skills.
Demonstrated problem-solving skills, scientific judgment, and attention to detail.
Understanding of laboratory safety, applicable regulations, and documentation requirements.
Ability to work independently while contributing effectively to a collaborative research team.
Experience with human pluripotent stem cell culture.
Supplemental technical training in cell biology, molecular biology, or a related scientific discipline.
Experience evaluating new laboratory technologies and supporting their implementation.
Previous experience mentoring technicians or junior-level scientists.
Familiarity with electronic laboratory notebooks, SOPs, and scientific documentation practices.