Scientist

Job#: 3043983

Job Description:

Seeking a Scientist to join a Research Company in Cambridge, MA.

Role Overview

Our client is seeking an experienced, independent scientist to help drive the design, execution, and interpretation of studies supporting our engineered suppressor tRNA (sup-tRNA) pipeline in rare diseases. In this role, you will take ownership of research questions across multiple biological scales from molecular and biochemical characterization through in vivo efficacy and translational modeling. You will bring both the technical depth to execute complex studies and the judgment to design and troubleshoot experiments with minimal oversight, while working closely with a cross-functional team.

Key Responsibilities

• Independently designing, executing, and interpreting in vivo and in vitro studies evaluating AAV-delivered sup-tRNA gene therapy candidates, including dosing, tissue collection, and biodistribution and efficacy assessments.
• Leading the characterization of novel disease models through integrated molecular, biochemical, and functional analyses to inform go/no-go decisions.
• Applying quantitative molecular techniques (e.g., ddPCR, qPCR/RT-qPCR) to measure vector genomes, transgene and target protein expression, and biodistribution.
• Assessing protein-level readouts of therapeutic efficacy via JESS Western blot, ELISA, immunohistochemistry, MSD, or related methods.
• Contributing scientific strategy and study design input to IND-enabling packages, target product profiles, and regulatory or partnering documents.
• Presenting data and recommendations to the leadership team, translating complex datasets into clear conclusions.
• Collaborating cross-functionally with CMC, analytical development, and external CROs/CDMOs, and mentoring junior scientists as needed.
• Maintaining rigorous documentation and experimental records consistent with GLP-adjacent and IND-enabling study expectations.

Required Qualifications

Education: A BS, MS or PhD in a biological or chemical discipline is required.

Experience: Several years of relevant industry experience is necessary. Prior experience in the biotech or pharmaceutical industry, ideally within a gene therapy, rare disease, or drug discovery/development setting, is expected. A demonstrated track record of designing and independently executing experiments and studies is required.

Technical Skills: Hands-on expertise in molecular and protein-based assays (e.g., ddPCR/qPCR, Western blot, ELISA, IHC) is needed. In vivo experience in rodent models, such as dosing, tissue collection, necropsy/dissection, and behavioral or functional phenotyping, is also required.

Preferred Qualifications

• Experience with AAV biology and workflows, including vector titering.
• Strong mathematical skills are preferred.
• A collaborative, team-oriented working style paired with the independent judgment to drive projects forward proactively in a fast-paced environment.
• Strong scientific communication skills, with the ability to synthesize data for both technical and cross-functional audiences.

Everforth Apex is a world-class IT services company that serves thousands of clients across the globe. When you join Everforth Apex, you become part of a team that values innovation, collaboration, and continuous learning. We offer quality career resources, training, certifications, development opportunities, and a comprehensive benefits package. Our commitment to excellence is reflected in many awards, including ClearlyRateds Best of Staffing in Talent Satisfaction in the United States and Great Place to Work in the United Kingdom and Mexico.

Everforth Apex uses a virtual recruiter as part of the application process. Click here for more details. By applying for this job, you agree to receive calls, AI-generated calls, text messages, or emails from Everforth Apex and its affiliates, and contracted partners. Frequency varies for text messages. Message and data rates may apply. Carriers are not liable for delayed or undelivered messages. You can reply STOP to cancel and HELP for help. You can access our privacy policy at https://www.apexsystems.com/privacy-policy

Everforth Apex Benefits Overview: Everforth Apex offers a range of supplemental benefits, including medical, dental, vision, life, disability, and other insurance plans that offer an optional layer of financial protection. We offer an ESPP (employee stock purchase program) and a 401K program which allows you to contribute typically within 30 days of starting, with a company match after 12 months of tenure. Everforth Apex also offers a HSA (Health Savings Account on the HDHP plan), a SupportLinc Employee Assistance Program (EAP) with up to 8 free counseling sessions, a corporate discount savings program and other discounts. In terms of professional development, Everforth Apex hosts an on-demand training program, provides access to certification prep and a library of technical and leadership courses/books/seminars once you have 6+ months of tenure, and certification discounts and other perks to associations that include CompTIA and IIBA. Everforth Apex has a dedicated customer service team for our Consultants that can address questions around benefits and other resources, as well as a certified Career Coach. You can access a full list of our benefits, programs, support teams and resources within our 'Welcome Packet' as well, which an Everforth Apex team member can provide.

Everforth Apex Systems is an equal opportunity employer. We do not discriminate or allow discrimination on the basis of race, color, religion, creed, sex (including pregnancy, childbirth, breastfeeding, or related medical conditions), age, sexual orientation, gender identity, national origin, ancestry, citizenship, genetic information, registered domestic partner status, marital status, disability, status as a crime victim, protected veteran status, political affiliation, union membership, or any other characteristic protected by law. Everforth Apex will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law.

If you require an accommodation under the Americans with Disabilities Act to participate in an interview with a virtual recruiter or to use our website for a search or application, please contact our Benefits Department at [email protected] or 804-523-8228. Please note that this contact information is strictly to be used for medical ADA accommodations and that no other inquiries will be answered.

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Employee Type:

Contract

Location:

Cambridge, MA, US

Job Type:

Date Posted:

July 29, 2026

Pay Range:

$45 - $65 per hour

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