Research Scientist, Proteomics & Mass Spectrometry (Contract)

General Summary

Vertex Pharmaceuticals is seeking a Contract Research Scientist, Proteomics & Mass Spectrometry to join the Chemical Biology group. This on-site laboratory role supports mass spectrometry–based research in proteomics, and targeted quantification of small molecules and lipids. The position supports research activities including target discovery, screening validation, biomarker research, and mechanism-of-action investigations within Chemical Biology and across functions in Boston Research.

Key Responsibilities

• Execute established sample-preparation and LC-MS workflows for proteomic, chemoproteomic, lipid, and small-molecule experiments.
• Prepare samples for mass spectrometry, including cell lysis, protein extraction, analyte enrichment or depletion, labeling, immunoprecipitation, enzymatic digestion, cleanup, and extraction. This includes use of liquid-handling instrumentation.
• Generate and operate LC-MS assays, including DIA, DDA, PRM, and related workflows.
• Operate, maintain, calibrate, and perform first-line troubleshooting of LC-MS systems, including Thermo and Bruker platforms.
• Monitor defined instrument-performance and assay-quality metrics; identify and escalate performance trends or technical issues according to laboratory procedures.
• Process mass spectrometry data using established analysis workflows and software; complete routine data-quality review, visualization, reporting, and data upload or storage.
• Maintain laboratory supplies, reagents, consumables, and work areas needed to support scheduled experiments and instrument operation.
• Coordinate in a matrix team on experiment priorities and schedules, shared lab work, status and technical issues.
• Communicate experimental results and technical updates through ELNs, presentations and team discussions.

Education and Experience

• PhD with hands-on relevant experience in analytical chemistry, biochemistry, chemical biology or related field. Bachelors or MSc with equivalent years of relevant education, technical training, and directly applicable laboratory experience will be considered.
• 5+ years of hands-on experience with three or more of the following: protein or peptide sample preparation, proteomics, chemoproteomics, analytical chemistry, LC-MS lipid analysis, or small-molecule mass spectrometry.
• Experience following laboratory procedures for biological sample processing, including three or more of cell culture, cloning, proximity labeling, immunoprecipitation, automation, fractionation, digestion.
• 5+ years experience operating LC-MS instrumentation or directly supporting LC-MS experimental workflows including instrument maintenance, calibration, performance monitoring, and troubleshooting.
• Experience with one or more mass-spectrometry data-analysis platforms, such as Spectronaut, Skyline, Proteome Discoverer, MsFragger, or comparable software.

$60-$63/HR

This job posting is for a temporary role with a third-party agency partner on assignment at Vertex Pharmaceuticals (“Vertex”). The individual selected for this role will be offered the role as an employee of a third- party agency partner; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by the third-party agency partner upon offer. The pay rate range provided is a reasonable estimate of the anticipated compensation range for this job at the time of posting. The actual pay rate will be based on a number of factors, including skills, competencies, experience, location and/or being pursued and other job-related factors permitted by law. In addition, this role will be eligible for overtime pay, in accordance with federal and state requirements

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