WHAT WE DO: Calidi Biotherapeutics is a clinical-stage immuno-oncology company with proprietary technology that is revolutionizing the utilization of oncolytic viruses through an allogeneic cell-based delivery system. Calidi Biotherapeutics is advancing this potent stem cell and oncolytic virus combination for use in multiple difficult-to-treat oncology indications. Our team is also developing a universal cell delivery system to protect, amplify and potentiate oncolytic viruses currently in development.
GENERAL PURPOSE OF JOB: Performs research and/or development in collaboration with others for projects. Makes detailed observations, analyzes data and interprets results. Research involves the use of oncolytic viruses, tumor biopsies, murine and human cells cell lines, experimental cancer model tissues, and blood from cancer patients and healthy donors.
ESSENTIAL DUTIES AND RESPONSIBILITIES: Performs in vivo studies to evaluate efficacy in murine models Administraters test substances by various routes (i.e., intratumoral, IP, IV, SC, PO, topical, etc.) Performs mouse necropsies, tissue harvest, and mouse blood collection via: cardiac puncture, submandibular, retro orbital etc.), Performs in vivo imaging to monitor tumor growth (IVIS or equivalent). Manages and observes animals for general health and overall well-being Adheres to SOPs to ensure study integrity and quality Performs routine maintenance and propagation of established cell lines Collaborates with research teams on molecular cloning, qPCR, Flow cytometry, ELISA, IHC. Maintains accurate experiment records in various internal databases and perform basic data analysis Adheres to good health and safety practices and compliance with applicable EH&S rules and participating in mandatory safety training programs Independently performs all methods and conduct all study types commonly employed by the team Other duties as needed
EDUCATION and/or EXPERIENCE: B.S. or higher in life science, or related field 3+ years of experience animal laboratory setting Current knowledge of pre-clinical tumor models, animal handling and dosing. Strong hands-on experience with animal handling, dosing (Intratumoral, IP, IV, PO, and SC), bleeding, necropsy and tissue harvest Experience in cell culture, immuno-oncology, TILS isolation, and flow cytometry is a plus. Good organizational and documentation skills Dedication to working in a team-oriented environment to contribute to shared project Strong work ethic, self-motivation, and ability to multi-task in a fast-paced work environment Excellent communication skills with ability to effectively communicate with other research teams Strong knowledge of MS Word, Outlook, PowerPoint, Excel. Perform other duties as directed by Management
MATHEMATICAL SKILLS: Ability to work with mathematical concepts such as calculation of dilutions and statistical analyses. Ability to apply concepts such as fractions, percentages, ratios, and proportions to practical situations.
REASONING ABILITY: Ability to define problems, collect data, establish facts, and draw valid conclusions.
LANGUAGE SKILLS: Excellent communication skills with ability to effectively communicate with other research teams Ability to read and understand technical procedures Ability to write protocols and reports Ability to effectively present data and respond to questions from co-workers
The PERKS: Competitive Total Rewards package (Medical, Dental, Vision, 401k Safe Harbor Match) offered to full-time employees
WORK LOCATION: Calidi Biotherapeutics employment provides the opportunity to work in beautiful