Who We Are: At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.
What We Do: Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The companys diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntingtons disease, classic congenital adrenal hyperplasia, endometriosis and uterine fibroids, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X and Facebook. (*in collaboration with AbbVie)
About the Role: The Postdoctoral Research Scientist in Endocrine Disease Modeling will participate in developing and characterizing novel preclinical models of 21-hydroxylase deficiency (Congenital Adrenal Hyperplasia, CAH) at Neurocrine Biosciences. Working with internal colleagues across Research, Translational Sciences, and Drug Discovery, the individual will contribute to building innovative, tunable animal models to evaluate emerging therapeutics targeting HPA axis dysregulation.
Your Contributions (include, but are not limited to): The primary role is to initiate and conduct a novel research project focused on developing postnatal and tunable mouse models of impaired steroidogenesis
Design and execute in vivo studies utilizing genetic (siRNA-mediated knockdown, AAV-based rescue strategies) and pharmacologic approaches to model CAH
Characterize endocrine phenotypes through hormonal profiling of HPA and gonadal axis markers
Conduct molecular and transcriptomic analyses (including single-cell RNA sequencing) to define HPA axis remodeling
Perform immunohistochemical and structural analyses of adrenal, pituitary, and hypothalamic tissues
Evaluate behavioral phenotypes related to stress and sleep architecture in disease models
Assess therapeutic modulation of ACTH signaling pathways using MC2 receptor antagonists, CRFR1 antagonists, and related approaches
Prepare data summaries and present results to peers and colleagues at Neurocrine
Requirements: Ph.D. degree in endocrinology, neuroscience, physiology, pharmacology, molecular biology, or related life sciences discipline, with experience in the biotech/pharmaceutical industry OR prior postdoctoral experience in academia
Strong in vivo experience working with rodent models of disease
Experience with genetic or molecular modulation approaches, including siRNA, AAV-based gene delivery, or related technologies would be prefer
Experience with endocrine hormone quantification methods (e.g., immunoassays, LC-MS/MS)
Knowledge of adrenal biology, steroidogenesis, or HPA axis regulation preferred
Experience with transcriptomic approaches, including bulk or single-cell RNA sequencing, a plus
Experience with immunohistochemistry and tissue-based analyses
Behavioral phenotyping experience (stress paradigms, sleep analysis, qEEG) a plus
Experience in advanced experimental technologies and their application in drug discovery
Excellent critical analysis skills
Ability to assimilate internal and external research findings for application to new scientific projects
Maintains broad knowledge of scientific principles and possesses intellectual depth in one or more scientific areas
Advanced knowledge and demonstrated ability working with a variety of laboratory equipment and analytical tools
Ability to work effectively as part of cross-functional teams
Excellent computer skills
Strong communication, problem-solving, and analytical thinking skills
Ability to manage multiple deadlines across projects/programs with a high degree of accuracy and efficiency
#LI-DM1 Neurocrine Biosciences is an EEO/Disability/Vets employer. We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.
The annual base salary we reasonably expect to pay is $89,800.00-$123,000.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 20% of the earned base salary. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.