DescriptionTitle: Post-doctoral Fellow
Salary: Commensurate with experience
Department: Hematology and Medical Oncology
Physical work location: (must be proper street address) 1468 Madison Avenue, New York NY
Name PI or Supervisor: (include phone and email) Hanna Irie MD, PhD, (212) 241-3720, hanna.irie@mssm.edu
Administrative Contact: (phone and email) Randa Hazar, Randa.Hazar@mssm.edu
Responsibilities ----------------
The researcher will be engaged in translational cancer research projects focused on regulators of growth, survival and drug resistance of breast and other cancers, as well as their microenvironment, especially immune effectors. The researcher will use a broad range of approaches (genetic, cell biological and in vivo modeling) to understand how breast cancers, particularly triple negative breast cancers, resist chemotherapy treatments and metastasize. The projects also examine novel mechanisms that contribute to the growth and metastases of triple negative breast cancers. The researcher will utilize patient-derived xenograft models of breast cancer and organoid cultures to screen and validate novel therapeutic strategies in collaboration with chemical biologists. The researcher will also study how the immunomicroenvironment regulates response of breast and other cancers to chemotherapy/targeted therapies. The researcher will be expected to design and conduct experiments, be responsible for accurate record keeping and contribute to overall maintenance of the laboratory.
Background in cancer cell biology/models, genetics, molecular biology, biochemistry, or immunology is required. Experience with mouse tumor models and related procedures (handling, tumor cell injection, flow cytometry, mouse surgical procedures, IVIS imaging) strongly preferred.
Ph.D or MD/PhD required with at least two years of laboratory experience. Qualifications
Technical Duties ----------------
• Cell culture • Western Blot • Cell viability assays • qPCR • DNA preparation (bacterial transformation, DNA extraction, transfection) • Lentivirus production • Mouse handling (tumor cell injections, mouse surgeries, IVIS imaging) • Flow cytometry • Organoid development and culture • Microscopy • Lab record keeping • Contribute to laboratory maintenance
Educational and other Requirements for the position ------------------------------------------------
Minimum B.A./B.S. required with at least two years of laboratory experience. Candidates with M.A./M.S. or other advanced degrees will also be considered.
Experience Required: At least two years of wet bench laboratory experience
Goals/Outcomes of the Research Project --------------------------------------
The goals are to develop and validate novel therapeutics targeting novel oncogenes in breast cancer models.
Employer Description -------------------
Strength through Unity and Inclusion
The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai's unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.
At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally.
About the Mount Sinai Health System -----------------------------------
Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time - discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients' medical and emotional needs at the center of all treatment.
The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Reports Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report's "Best Children's Hospitals" ranks Mount Sinai Kravis Childrens Hospital among the country's best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek's "The World's Best Smart Hospitals" ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.
Equal Opportunity Employer -------------------------
The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.
Compensation -------------
The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72,500 - $80,000 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.