Post-Doctoral Associate - Department of Neuroscience

About the Job

This is a postdoctoral scientist position in Dr. Lees laboratory. Initial project involves cell biological and biophysical characterization of various alpha-synuclein aggregates/oligomers found in vivo (Mouse models and human tissue) that can induce neuropathology/neurodegeneration.

1. Subcellular fractionation of alpha-synuclein from mouse CNS and human brain with and without alpha-synuclein pathology. Basic biochemical characterization (25%)

2. Generation of recombinant alpha-synuclein and preformed fibrils (10%)

3. Seeded amplification of the subcellular fractions (15%)

4. Comparative analysis of the subcellular fractions and seeded amplified fibrils in cell models for seeding activity and toxicity (25%)

5. Biophysical analysis of the alpha-synuclein fibrils amplified from brain fractions, including cryo-EM analysis (25%)

Qualifications

Required Qualifications:

PhD in Neuroscience or related field.

Experience with the biophysical analysis of alpha-synuclein aggregation.

About the Department

The Department of Neuroscience is committed to providing excellence in research, education, and public service. The Department of Neuroscience is part of the University of Minnesotas Medical School. The Medical School and related healthcare professional schools are grouped under the Academic Health Center.

The Mission of the Department of Neuroscience

• Conduct outstanding neuroscience research.
• Be an educational resource to the Medical School and the University by providing neuroscience education to undergraduate, medical, dental, graduate, and post-graduate students.
• Provide leadership and be a focal point for the strengthening of neuroscience across the University by enhancing research, educational, and funding opportunities.
• Intentionally improve inclusivity by valuing diverse perspectives and actively supporting historically marginalized researchers, students, and neuroscience community members.
• Provide a bridge for the transfer of advances in basic neuroscience into clinical practice with the goal of improving the health of the people of Minnesota.
• Enhance the understanding and appreciation of neuroscience by the people of Minnesota.

Pay and Benefits

Pay Range: $63,480 per year

Please visit the Benefits for Postdoctoral Candidates website for more information regarding benefit eligibility.

• Competitive wages, paid holidays, and generous time off
• Continuous learning opportunities through professional training
• Medical, dental, and pharmacy plans
• Healthcare and dependent care flexible spending accounts
• University HSA contributions
• Disability and life insurance
• Employee wellbeing program
• Financial counseling services
• Employee Assistance Program with eight sessions of counseling at no cost

How To Apply

Applications must be submitted online. To be considered for this position, please click the Apply button and follow the instructions. You will be given the opportunity to complete an online application for the position and attach a cover letter and resume.

Additional documents may be attached after application by accessing your "My Job Applications" page and uploading documents in the "My Cover Letters and Attachments" section.

To request an accommodation during the application process, please e-mail jobcentr@umn.edu.

Diversity

The University recognizes and values the importance of diversity and inclusion in enriching the employment experience of its employees and in supporting the academic mission. The University is committed to attracting and retaining employees with varying identities and backgrounds.

The University of Minnesota provides equal access to and opportunity in its programs, facilities, and employment without regard to race, color, creed, religion, national origin, gender, age, marital status, disability, public assistance status, veteran status, sexual orientation, gender identity, or gender expression. To learn more about diversity at the U: http://diversity.umn.edu

Employment Requirements

Any offer of employment is contingent upon the successful completion of a background check. Our presumption is that prospective employees are eligible to work here. Criminal convictions do not automatically disqualify finalists from employment.

About University of Minnesota

The University of Minnesota, Twin Cities (UMTC)

The University of Minnesota, Twin Cities (UMTC), is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nations most vibrant, diverse metropolitan communities, students on the campuses in Minneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations.

At the University of Minnesota, we are proud to be recognized by Forbes as a Best Employer for Company Culture (2026), Best Employer for Women (2023, 2025, 2026), and Best Employer by State (2022-2026). In 2026, we also received Culture Excellence & Industry Awards recognition for employee appreciation and work-life flexibility.