PKPD Principal Scientist

At Metrum Research Group, we combine cutting-edge science, data, and technology to solve complex challenges in drug development and healthcare innovation. We are seeking an experienced scientist who enjoys staying close to the science—bringing strong hands-on modeling and simulation expertise, including NONMEM, while also providing scientific project leadership and working directly with clients. This role is ideal for someone who thrives in a collaborative, agile environment and wants to contribute both as an individual scientist and a scientific leader. Join a team that values innovation, scientific rigor, and real-world impact, where your work truly matters.

Responsibilities

• Scientific lead on the project and be the client's main source of contact. 
• Perform all aspects of modeling and simulation to support drug development and clinical trials.
• Provide consultation and technical guidance for clients.
• Prepare reports and presentations for internal and external dissemination.
• Works collaboratively within assigned agile project team(s) to accomplish team goals.
• Participate in MetrumRG training courses as a teacher or aid.
• Present and publish scientific findings.
• Provide mentoring to scientific staff.
• Serve a leadership role in advancing the goals of the company.
• Project scoping and proposal preparation.
• Generate new business leads.

Requirements, Skills

• Excellent written and verbal communication skills.
• Demonstrated proficiency in applying NONMEM modeling and simulation tools to quantitative decision-making.
• Perform programming and use statistical tools such as stan, R, or SAS.
• Ability to sit on drug development teams as pharmacometrician or statistician or systems pharmacologist.
• Desired: Perform Bayesian data analysis.
• Ability to work with others to complete team level tasks.
• Fluent in the use of Internet technologies and web-based software.

Education and Experience

Ph.D. degree in a scientific discipline (pharmaceutical sciences, pharmacokinetics, mathematics, statistics, biomedical engineering or a related field) or Master's degree with relevant experience, or equivalent.

Experience:  10+  years direct postgraduate experience. Demonstrated technical abilities and desire to advance the science and assume a leadership position within the company and scientific community.

Physical Demands

The job frequently requires working at a computer terminal, standing or sitting, and the ability to operate the computer with proficiency.

Work Environment

The work environment is quiet with no adverse conditions.

Metrum Research Group is an Equal Opportunity Employer

Metrum Research Group EEO Statement

MetrumRG believes that innovation is cultivated when we challenge each other with new ideas and perspectives. MetrumRG is an equal opportunity employer that is committed to building a diverse and inclusive team. All employment decisions are based on qualifications, merit, and business needs, and we prohibit discrimination and harassment of any kind based on race, color, sex, religion, sexual orientation, gender identity, national origin, disability, genetic information, pregnancy, or any other protected characteristic as outlined by federal, state, or local laws.

MetrumRG is committed to providing equal employment opportunities and reasonable accommodations for candidates and employees with disabilities. We encourage all qualified candidates to apply for positions within our organization. If you require reasonable accommodation because of a medical condition for the application or interview process, please contact Scotti Rylands or our Talent and Culture Department, (860)735-7043 x-622, or message us and we will work with you to meet your needs.