Job Description
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Job Title: Pediatrics - Neurology NRI (Instructor)
Division: Pediatrics
Work Arrangement:
Location: Houston, TX
Salary Range:
FLSA Status: Exempt
Work Schedule:
Summary
We are seeking a highly motivated and innovative Gene Editing Scientist to join a multidisciplinary team focused on developing cutting-edge human models of disease and advancing translational applications in neurodevelopmental and neurodegenerative disorders. The successful candidate will lead and execute genome engineering strategies across a range of platforms, including human induced pluripotent stem cells (iPSCs), 2D human brain models, and organoids. This position offers a unique opportunity to contribute to transformative discoveries at the intersection of gene editing and human disease modeling.
Job Duties
- Design, develop, and optimize genome editing strategies using CRISPR/Cas systems (e.g., CRISPR-Cas9, base editing, prime editing)
- Generate and validate genetically modified cell lines, including iPSCs and differentiated neural cell types
- Perform clonal selection, screening, and molecular validation (PCR, sequencing, off-target analysis)
- Collaborate with cross-functional teams (genetics, bioinformatics, cell biology, electrophysiology) to integrate multi-omics and functional data
- Maintain detailed experimental records and contribute to publications, grant applications, and presentations
- Stay current with emerging genome editing technologies and implement innovative approaches
- Ensure compliance with institutional biosafety and regulatory guidelines
Minimum Qualifications
- Ph.D. in Molecular Biology, Genetics, Neuroscience, Bioengineering, or related
- field
- 3+ years of hands-on experience in genome editing, particularly CRISPR-based
- approaches
- Demonstrated expertise in mammalian cell culture, including stem cells (iPSCs
- preferred)
- Experience with cloning, vector design, and delivery systems (viral and non-viral)
- Strong background in molecular biology techniques (PCR, qPCR, NGS, Western
- blotting)
- Experience with clonal isolation and validation of edited lines
- Ability to design experiments independently and troubleshoot complex protocols
- Strong organizational, analytical, and communication skills
Preferred Qualifications
- Experience with advanced genome editing technologies (base editing, prime editing, epigenome editing)
- Familiarity with iPSC-derived models including organoid systems or 3D cell culture models
- Experience working with neurological or developmental disease models
- Knowledge of off-target analysis and genome-wide screening approaches
- Experience with automation/robotics platforms for cell engineering workflows
- Bioinformatics skills related to sequence analysis
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.
Requisition ID: 25341
Apply now