The antigen manufacturing operation is made up of teams that carry out the production activities for the preparation and sterilization of equipment, preparation and sterilization of media components, fermentation of bacterial antigens, downstream processing of bacterial antigens and serial batching of antigens to blend the final vaccines prior to sterile filling. Department activities include cleaning, set up and sterilization of large scale filtration equipment and the concentration/filtration of antigen batches required for final vaccine blending.