Jr. Scientist II/X-Ray Crystallographer

Work independently and as part of a scientific team to understand and resolve complex biological questions while contributing to product development through the analysis and interpretation of data, presentation of data at meetings, the establishment of collaborations both internal and external to WRAIR, and the solicitation of grants and the writing of successful proposals. Develop and recommend antimicrobial drug candidates for specific targets on MDR ESKAPEE pathogens ( Enterococcus species, Staphylococcus aureus , Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa , Enterobacter cloacae , and Escherichia coli ).

Position Summary:

Odyssey is looking for a Jr. Scientist II, Xray Crystallography, to join a dynamic and growing team at the Walter Reed Army Institute of Research (WRAIR) Wound Infection Department (WID).  WID is tasked with delivering specific, effective countermeasures for infection of combat wounds pre-injury, at the point-of-injury, and post-injury.  The Structural Biology (XTAL) group focuses on structure-based drug designs for microbial pathogens of military relevance.  Researchers in this group express, purify and crystallize ESKAPEE pathogen proteins of interest and utilize sophisticated techniques such as X-ray Crystallography and Mass Spectroscopy to model small molecule drug-protein interactions.

Responsibilities:

Duties include, but not limited to: 

• Be familiar with the field's concepts, practices, and procedures, including, but not limited to, microbiology, immunology, vaccinology, biochemistry, genetics, molecular biology, clinical trials, and bioinformatics.
• Work independently and as part of a scientific team to understand and resolve complex biological questions while contributing to product development through the analysis and interpretation of data, presentation of data at meetings, the establishment of collaborations both internal and external to WRAIR, and the solicitation of grants and the writing of successful proposals.
• Actively pursue the scientific objectives of the Branch and contribute significantly to the critical strategic planning and execution of future studies.
• Design, develop and deliver novel small molecule antibiotics against MDR organisms of military relevance through structure-based drug design.
• Identify novel small-molecule drug candidates through in silico screening of commercially available chemical databases and molecular modeling of drug candidates for enhancement.
• Express, purify and crystallize proteins for structure-based drug design and perform mass spectrometry on all products.
• Develop and recommend antimicrobial drug candidates for specific targets on MDR ESKAPEE pathogens (Enterococcus species, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter cloacae, and Escherichia coli).
• Draft grant proposals on structure-based drug design for submission to leadership and research steering committees.
• Conduct research on projects associated with antimicrobial development such as protein expression and purification, MIC (minimum inhibitory concentration) studies, animal modeling, virtual modeling of drugs bound to target proteins, etc.
• Independently design experiments, make detailed observations, analyze data, interpret results and deliver timely results.
• Mentor and supervise junior scientists within the team as needed.

Qualifications:

Minimum Required Qualifications:

Citizenship:  Must be a US citizen or Green Card holder and lived in the U.S. three out of the last five years

Clearance: Ability to Obtain NACI

Education: Ph.D. in an appropriate discipline (e.g., microbiology, immunology, Molecular Biology or biochemistry)

Years of Experience: At least three (3) years of experience in protein characterization and chemistry

 

Preferred Qualifications:

Clearance: NACI

Education: Ph.D. in an appropriate discipline (e.g., microbiology, immunology, Molecular Biology or biochemistry)

Years of experience: 3-5 years of experience in protein characterization and chemistry

 

Technical Skills

• Experience and training using BRUKER X-Ray Diffractometers.
• Experience in at least one of the following areas: druggable target identification, cloning, enzymology, protein characterization and protein chemistry.
• Strong computer skills and experience with relevant software, including MS Office and GraphPad Prism.
• Experience with microbiology of Gram-negative negative species and antibacterial development is desired.
• Must have a proven track record of securing competitive grant funding.
• Must have excellent presentation and oral and written communication skills.
• Ability to prioritize and work in a fast-paced and diverse environment. Contribute individually as well as part of a highly collaborative and productive team.
• Must have proven ability to prepare precise technical summaries and protocols and maintain appropriate documentation.

Interpersonal Skills

• Teamwork
• Problem-Solving
• Critical Thinking
• Communication
• Attention to Detail

Additional Information

Location: Walter Reed Army Institute of Research (Silver Spring, MD)

Travel: 5%

Remote, Onsite, or Hybrid: Onsite

 

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Company Overview:

Odyssey is a world-class technical, engineering, and integration company serving the warfighting ecosystem with airborne integration, ISR, C2, and warfighter readiness capabilities. Odyssey meets the military’s operational needs by integrating layered defense systems from equipment, technology, and services to data, information, and business operations. We streamline defense acquisition and sustainment, engineering the technical battlefield with domain-specific proficiency to ensure lethality. Odyssey is dedicated to excellent contract execution, peak organizational performance, and fostering a workplace built on employee care.

 

Odyssey is proud to live out our core values of commitment, ambition, and respect in our work and communities through OdysseyCares, a philanthropic group focused on giving back through direct donations, an employer match program, and volunteering events.

 

Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Please Note::

Final compensation for this position will be determined by various factors such as the Federal Government contract labor categories and contract wage rates, relevant work experience, specific skills and competencies, geographic location, education, and certifications.

 

This position is filled through continuous recruitment and will remain open until a sufficient pool of applications has been received.

Hired applicants may be eligible for benefits, including but not limited to, medical, dental, vision, life insurance, Tricare supplement, short-term disability, long-term disability, 401(k) match, flexible spending accounts, health savings accounts, employee assistance program, learning and development benefit, paid time off, and holidays.

Odyssey Benefits