Clinical Contracts Manager, Cambridge, MA

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease.

The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery.

Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture.

The world we want tomorrow is the one we're building today. It starts with the culture at this company. It starts with you.

About Iso

Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed.

Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI's powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world's most devastating diseases.

We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design.

Every day, and with each new breakthrough, we're getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI.

Your impact

The Clinical Contracts Manager acts as the primary point of contact for all vendor outsourcing and business contracting initiatives within their assigned therapeutic and functional areas. Operating at an organizational level, this role drives vendor selection, supports negotiation of Master Service Agreements (MSAs) and Clinical Trial Agreements (CTAs), and manages vendor related study budgets and contract lifecycle activities. The Clinical Contracts Manager collaborates closely with Clinical Operations, Data Management, Clinical Sciences, Clinical Systems, Biosample Operations, Finance, Legal, and other cross-functional stakeholders to ensure predictable trial execution, financial alignment, and compliance with GCP and FDA regulatory standards.

What you will do

Vendor Management & Contracting

• Provide primary outsourcing and vendor management support for clinical development functional areas across the portfolio.
• Independently lead RFI and RFP processes, analyze supplier services, proposals, and budgets, conduct bid defense meetings, and recommend vendor selection for executive decision-making.
• Negotiate and execute complex vendor agreements and Master Service Agreements (MSAs) with preferential terms and pricing.
• Define and implement vendor assessment criteria, benchmark metrics, and process improvement initiatives to optimize clinical outsourcing.

Clinical Trial Execution & Site Support

• Drive negotiations for Clinical Trial Agreements (CTAs) and investigator budgets directly with clinical sites.
• Partner closely with Clinical Trial Managers, program teams, and CROs to ensure vendors deliver against study timelines, quality standards, and budget expectations.
• Assess and integrate potential AI tools to facilitate and enable contract negotiations and management.
• Ensure full consistency between contractual agreements and operational trial implementation.
• Monitor study progress, vendor deliverables, and resource allocation throughout the study lifecycle, supporting teams in final financial reconciliation at study closeout.

Risk Management, Compliance & Governance

• Actively monitor study progress for scope changes, driving negotiations for change orders and associated costs to minimize sponsor risk.
• Identify contractual risks, mitigate scope creep, and ensure strict adherence to Fair Market Value (FMV) standards, legal requirements, and healthcare compliance.
• Proactively address contractual challenges, develop risk mitigation plans, and facilitate escalation management for leadership review when needed.
• Participate in vendor oversight and governance meetings, supporting study teams in resolving vendor performance issues.
• Seek out, assess and potentially assist in onboarding potential AI solutions within this space that would prove helpful to the organization

Skills and qualifications

Essential:

• Bachelor's degree (BA/BS); degree in Healthcare, Science or Finance preferred.
• Minimum 5+ years of experience in clinical outsourcing, contracting, procurement, or finance within a pharmaceutical, biopharma, CRO, or clinical research setting.
• In-depth knowledge of clinical trial execution, CRO outsourcing models, and regulatory guidelines (GCP/FDA).
• Oncology and/or Rare Disease experience required.
• Ability to confidently and independently complete and/or drive all key responsibilities listed above.
• Strong contract negotiation, budget management, and project management skills with a proven track record across multi-project timelines.
• Exceptional written and oral communication skills, with the ability to convey engagement objectives and maintain effective dialogue with internal and external partners.
• Demonstrates an AI-curious mindset, with an interest in exploring and leveraging emerging AI technologies to streamline contract lifecycle management and enhance operational efficiency.
• Strategic and analytical thinker with excellent problem-solving capabilities and adaptability in fast-paced, matrixed environments.
• Proven ability to build strong cross-functional relationships, mentor team members, and drive efficient business solutions across functional and regional boundaries.

Culture and values

We are guided by our shared values. It's not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it.

Thoughtful

Thoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day.

Brave

Brave at Iso is about fearlessness, but it's also about initiative and integrity. The scale of the challenge demands nothing less.

Determined

Determined at Iso is the way we pursue our goal. It's a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it. Because disease won't wait, so neither should we.

Together

Together at Iso is about connection, collaboration across fields and catalytic relationships. It's knowing that transformation is a group project, and remembering that what we're doing will have a real impact on real people everywhere.

Creating an extraordinary company

We believe that to be successful we need a team with a range of skills and talents. We're building an environment where collaboration is fundamental, learning is shared and every employee feels supported and able to thrive. We value unique experiences, knowledge, backgrounds, and perspectives, and harness these qualities to create extraordinary impact.

We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please do not hesitate to let us know.

Hybrid working

It's hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you're in). If you have additional needs that would prevent you from following this hybrid approach, we'd be happy to talk through these if you're selected for an initial screening call.

Please note that when you submit an application, your data will be processed in line with our privacy policy.

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As an AI-first company, we embrace tools like Gemini. However, our interview process is designed to understand your unique expertise and problem-solving skills, as well as what motivates you. Therefore, we ask that you refrain from using any AI tools, transcription services, or other assistants during your interview and assessment process, unless you've made prior arrangements with our Talent team for specific needs or accommodations. (If you require any adjustments, please discuss this with the Talent team during your initial screening call.) *

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