Cell Biology & Functional Genomics Scientist III

Perform tissue, cell, and nuclei dissociation and execute NGS workflows for bulk RNA-seq, single-cell RNA-seq, single-nucleus RNA-seq, and related applications, including library preparation, quality control, quantification, normalization, sequencing setup, and sequencer operation. Perform routine molecular biology techniques, including DNA/RNA extraction, PCR and qPCR, nucleic acid and protein quantification, Western blotting, and basic sample preparation; analyze and interpret results, identify technical issues, and communicate findings and recommended follow-up clearly.

Job Title: Cell Biology & Functional Genomics Scientist III
Location: Ridgefield, Connecticut
Type: Contract
Compensation: $43.00 - $49.50/hr
Work Model: Onsite
Hours: 40.0

Responsibilities

• Design, execute, and analyze cell-based experiments supporting target validation and discovery research, including routine mammalian cell culture, assay execution, image-based analysis, and iPSC-derived cell workflows.
• Operate and monitor established laboratory automation workflows for cell-based and molecular assays, troubleshoot routine issues, and escalate complex problems appropriately.
• Perform tissue, cell, and nuclei dissociation and execute NGS workflows for bulk RNA-seq, single-cell RNA-seq, single-nucleus RNA-seq, and related applications, including library preparation, quality control, quantification, normalization, sequencing setup, and sequencer operation.
• Perform routine molecular biology techniques, including DNA/RNA extraction, PCR and qPCR, nucleic acid and protein quantification, Western blotting, and basic sample preparation; analyze and interpret results, identify technical issues, and communicate findings and recommended follow-up clearly.
• Maintain accurate sample, reagent, consumable, experimental metadata, and electronic laboratory notebook records while complying with SOPs, safety requirements, company policies, and data integrity standards.
• Collaborate across cell biology, automation, genomics, and bioinformatics groups.

Requirements

• Master’s degree with 3+ years of relevant experience; or Bachelor’s degree with 7+ years of relevant experience; or Equivalent combination of education and experience in cell biology, molecular biology, genomics, or a related scientific discipline
• Strong hands-on experience with mammalian cell culture, cell biology, and cell-based assay execution.
• Hands-on NGS workflow experience, including tissue, cell, and/or nuclei dissociation, sequencing library preparation, quality control, and quantification for bulk RNA-seq, single-cell RNA-seq, single-nucleus RNA-seq, or related applications.
• Some hands-on experience with laboratory automation, automated instrumentation, or standardized high-throughput workflows, with the ability and interest to develop further expertise in operating and troubleshooting automated cell-based and molecular assays; automation programming is not required.
• Exceptional attention to detail and demonstrated ability to accurately execute lengthy, multi-step protocols while maintaining sample integrity, data quality, and complete documentation.
• Ability to independently troubleshoot routine experimental or operational issues, communicate clearly, and work effectively in a collaborative research environment.

System One, and its subsidiaries including Joulé and Mountain Ltd., are leaders in delivering outsourced services and workforce solutions across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan.

System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.
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