Sr. Manager, Cell-Based High Throughput Screening and Mechanistic Pharmacology

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com.

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About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for Sr. Manager, Cell-Based High Throughput Screening and Mechanistic Pharmacology in Spring House, PA.

Purpose: The Discovery Technologies and Molecular Pharmacology (DTMP) team is a critical part of the Discovery Sciences organization in Johnson & Johnson Innovative Medicines and is committed to the delivery of high-quality chemical leads needed for the generation of small molecule clinical compounds across Therapeutic Area discovery teams. As a member of the DTMP team, the Sr Manager will interact with diverse scientific disciplines including biochemistry, cellular pharmacology, hit identification, and protein science.

Within DTMP, the Mechanistic and Cell Pharmacology department is responsible for the delivery of high-quality small molecule lead compounds by applying rapid, innovative, and therapeutically relevant cellular assays from target concept through the lead optimization process.  We are seeking a highly motivated, experienced, and innovative scientific leader to drive the implementation of High Throughput (HT) cell-based assays.  The ideal candidate will have strong oral and written communication skills and the ability to connect with our partners to deliver on goals and objectives, foster an environment of collaboration, collegiality, and positive communication. This position includes management responsibility.

You will be responsible for:

• Lead a team of scientists to implement recombinant, primary, and/or complex cell-based assays with a variety of endpoints to enable de novo lead identification from large scale screening campaigns.
• Conceive of and implement hit finding plans in collaboration with therapeutic area stakeholders and multidiscipline DTMP teams.
• Build understanding of on target mechanism of action and signaling, deploying diversity of cell-based pharmacological approaches designed to differentiate lead molecules, establish in vitro/in vivo correlations, and identify drivers of PK/PD relationships.
• Oversee, execute, and troubleshoot weekly assays in support of medicinal chemistry efforts, assuring high-quality data analysis and reporting.
• Exhibit an awareness of new technology advances and scientific knowledge in cellular bioassay methods to apply them to assays in the laboratory.
• Contribute data and methods to compelling scientific presentations and reports for internal review meetings and scientific journals.

Qualifications/Requirements:

• Education: Minimum of a M.S. Degree in Cell Biology and/or Physiology, Immunology, Oncology, Neuroscience, or relevant field with an additional 8-10 years of pharmaceutical or biotechnology industry experience is required.  PhD with 5-8 years of experience is preferred.

Skills/Experience:

• Knowledge of lab automation is required.
• Proven experience leading multi-disciplinary teams supporting cell-based pharmacology lead identification and lead optimization functions.
• Possess strong working knowledge of basic molecular pharmacology including modes of target inhibition and activation.
• Broad target class expertise in the establishment of robust miniaturized cell-based assays in automated plate-based formats including readouts such as fluorescence, chemiluminescence, and TR-FRET.
• Demonstrated ability to construct hit finding and hit progression strategies.
• Demonstrated ability to analyze, visualize, and interpret large (>1MM) data sets to enable hit triage.
• Demonstrated excellence in both written and oral communication is required.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. 

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers , internal employees contact AskGS to be directed to your accommodation resource.

If you are under 18 years of age you (the candidate) may need to obtain the necessary working papers or other documentation required by state law to start the assignment, as well as get a parent’s consent for the background check

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