Job Title: Senior Scientist I / II - Translational Experimental Cancer Biology (OTR)#LI-OnsiteLocation: Cambridge, USARelocation Support: This role is based in Cambridge, USA. Novartis is unable to offer relocation support: please only apply if accessible.Drive the mechanistic understanding of how cancer therapies succeed-and fail-at the cellular level. Within Oncology Translational Research, you will interrogate therapeutic response and resistance in breast cancer using advanced molecular and cellular biology approaches, including engineered human cell line systems and functional assays. Working at the interface of discovery and early clinical development, you will generate high-resolution insights into intrinsic and acquired resistance pathways, enabling patient stratification strategies and informing the design of next-generation therapies with improved efficacy, durability, and safety.Key ResponsibilitiesLead mechanism-of-action studies to interrogate therapeutic response and resistance in breast cancer modelsDesign and execute in vitro assays to uncover intrinsic and acquired resistance pathwaysEngineer and optimize human cell line models for functional screening and mechanistic investigationsCollaborate cross-functionally across discovery, data science, and early clinical development teamsAnalyze, interpret, and clearly communicate experimental data to drive translational insightsDocument experiments rigorously and maintain high-quality scientific records and reproducibility standardsStay current with emerging scientific literature and integrate new methodologies into research strategiesEssential RequirementsDoctor of Philosophy in biology, cancer biology, molecular biology, or a related scientific disciplineStrong expertise in cell biology and advanced molecular biology techniquesProven experience studying resistance to small molecule therapies using molecular approachesDeep understanding of hormone-driven cancer biology, including breast or prostate cancerExperience designing and executing in vitro assays to investigate cellular mechanismsDemonstrated ability to engineer and work with human cell line modelsStrong problem-solving skills, scientific curiosity, and ability to interpret complex biological dataProven ability to collaborate effectively within multidisciplinary scientific teamsDesirable RequirementsExperience with data mining and computational analysis applied to biological datasetsFamiliarity with single-cell sequencing or spatial transcriptomics approachesNovartis Compensation and Benefit Summary: The salary for this position is expected to range between $98,700.00 - 183,300.00 USD Annual per year.The final salary offered is determined based on factors like, but not limited to, relevant skills andexperience, and upon joining Novartis will be reviewed periodically. Novartis may change the publishedsalary range based on company and market factors.Your compensation will include a performance-based cash incentive and, depending on the level of therole, eligibility to be considered for annual equity awards.US-based eligible employees will receive a comprehensive benefits package that includes health, life anddisability benefits, a 401(k) with company contribution and match, and a variety of other benefits. Inaddition, employees are eligible for a generous time off package including vacation, personal days,holidays and other leaves.
Novartis provides healthcare solutions that improve and extend people’s lives. We use science-based innovation to address some of society’s most challenging healthcare issues. We discover and develop breakthrough treatments and find new ways to deliver them to as many people as possible. Our company is focused on industry-leading divisions with innovation power and global scale: pharmaceuticals, eye care and generic medicines Novartis is headquartered in Basel, Switzerland. Novartis Group companies employ approximately 120,000 associates and its products are available in more than 180 countries around the world.