Non-Solicitation Policy and Notice to Agencies and Recruiters
IDEAYAs Non-Solicitation Policy strictly prohibits agencies and recruiters from any contact and communication with IDEAYA employees, managers, and leaders to submit unsolicited candidate resumes and/or to solicit business partnerships. Submission of unsolicited candidate resumes by agencies or recruiters with or without a contract in place with IDEAYA Biosciences Inc. will not create any implied obligation. Failure to comply with this policy will result in disqualification from current and future business opportunities with IDEAYA Biosciences. All recruiting and talent agency decisions are strictly managed by the internal IDEAYA Human Resources function. All communication by external agencies and recruiters must be directed to humanresources@ideayabio.com. We ask that you only email your interest once.
Job Summary
About IDEAYA Biosciences
IDEAYA is a precision medicine oncology company committed to the discovery, development, and commercialization of transformative therapies for cancer. Our approach integrates expertise in small-molecule drug discovery, structural biology and bioinformatics with robust internal capabilities in identifying and validating translational biomarkers to develop tailored, potentially first-in-class targeted therapies aligned to the genetic drivers of disease. We have built a deep pipeline of product candidates focused on synthetic lethality and antibody-drug conjugates, or ADCs, for molecularly defined solid tumor indications. Our mission is to bring forth the next wave of precision oncology therapies that are more selective, more effective, and deeply personalized with the goal of altering the course of disease and improving clinical outcomes for patients with cancer. When youre at IDEAYA, you will be in the midst of brilliant minds working on precision medicine therapies to help cancer patients. We are passionate and committed about being on the forefront of oncology medicine, which means we all have a high internal drive that is at the very core of every person at IDEAYA. We are inquisitive, ask deep questions, and are data-driven innovators who like to collaborate and use team work to move science forward. For more information, please see www.ideayabio.com.
Location: South San Francisco, CA
Position Summary
We are seeking an accomplished Senior Principal Research Scientist in Computational Chemistry with significant pharmaceutical industry experience to join our multidisciplinary small molecule drug discovery organization. This is a senior individual contributor role for a highly experienced computational chemist with a strong track record of advancing pharmaceutical discovery programs through hands-on scientific impact.
The successful candidate will support discovery project teams across target identification, hit discovery, lead optimization, and drug candidate selection. The role requires a high degree of independence, technical depth, and scientific judgment. The candidate will apply modern computational chemistry approaches to directly inform medicinal chemistry design and project decision-making. We are looking for a creative, detail-oriented scientist with a passion for drug discovery and a collaborative mindset.
As part of the drug discovery team, the candidate will contribute directly to target assessment and druggability analysis, perform virtual screening and structure-based modeling, and work closely with medicinal chemists to design compounds with improved potency, selectivity, functional activity, and developability (e.g., ADME/DMPK). In addition to hands-on contributions, the candidate will mentor other scientists and share best practices to amplify the impact of computational chemistry across project teams.
What You'll Do
Lead structure-based drug design meetings with medicinal chemists and provide senior-level, hands-on drug design and computational chemistry support to small molecule drug discovery project teams.
Contribute to programs from target identification through lead optimization and drug candidate selection.
Apply structure-, ligand-, and fragment-based modeling to guide medicinal chemistry design.
Use molecular dynamics, free energy methods, quantum chemistry, and cheminformatics to address complex design and prioritization questions.
Translate computational analyses into clear, actionable compound design recommendations.
Serve as a highly experienced computational contributor and scientific advisor within project teams.
Mentor and coach other scientists in structure-based drug design through technical guidance and scientific discussion.
Evaluate new computational methods, tools, and workflows and apply them when they add clear value.
Maintain scientific rigor, reproducibility, and best practices in an industry drug discovery environment.
Requirements
PhD in Computational Chemistry or a related discipline with 9+ years of pharmaceutical or biotechnology industry experience.
Strong understanding of small molecule drug discovery and medicinal chemistry principles.
Demonstrated expertise in structure-, ligand-, and fragment-based drug discovery.
Expertise in free energy perturbation, molecular dynamics, quantum mechanics, cheminformatics, and ligand affinity estimation methods.
Proven ability to independently deliver computational work that influences medicinal chemistry decisions and project outcomes.
Ability to manage priorities across multiple discovery programs.
Excellent oral and written communication skills.
Experience applying machine learning or AI methods to molecular design, property prediction, or compound prioritization.
Experience with Schrödinger modeling software and others (e.g., MOE, OpenEye).
Programming, scripting, statistics, and data analysis experience applied to drug discovery.
Experience working on challenging target classes, including protein-protein interactions and allosteric pockets.
Track record of contributing to discovery programs that advance high-quality small molecule drug candidates.
Total Rewards
Along with our inspiring mission, and highly collaborative and inclusive environment, IDEAYA offers a competitive total rewards package that reflects our pay-for-performance philosophy where employees are eligible to be considered for merit-based salary increases, company discretionary short-term incentive plan participation, and company discretionary stock option awards (based on board approval). Our comprehensive benefits package includes, but is not limited to, medical/dental/vision coverage (100% company paid for employees and 90% company paid for dependents), 401k, ESPP, and wellness programs.
The expected salary range for the role of Senior Principal Research Scientist, Computational Chemistry is $196,000 - $242,000. The final salary offered to a successful candidate will depend on several factors that may include but are not limited to the office location where this open position is located, the final candidates' experience within their profession, experience in the disease areas we are striving to make an impact in as a company, length of time within the industry, educational background, and performance during the interview process.
Company Culture
IDEAYA is an equal opportunity employer. In accordance with applicable law, IDEAYA does not discriminate in hiring or otherwise in employment based on race, color, religion, sex, national origin, age, marital or veteran status, disability, sexual orientation, or any other legally protected status. EOE/AA/Vets.
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