Senior Director, Clinical Development

Mavericks Wanted

When was the last time you achieved the impossible? If that thought feels overwhelming, you might want to pause here, but if it sparks excitement...read on

In 2015, we pioneered a "moneyball for biotech" approach, pooling projects and promising early-stage research from academia together under one financial umbrella to reduce risk and unleash innovation. This model allows science and small teams of experts to lead the way. We build bridges to groundbreaking advancements in rare disease, and develop life-changing medicines for patients with unmet needs as fast as humanly possible.

Together we define white space, push boundaries, and empower people to solve problems. If you're someone who defies convention, join us and work alongside some of the most respected minds in the industry. Together, we'll ask "why not?" and help reengineer the future of biopharma. At BridgeBio, we value curiosity and experimentation-including the ethical & thoughtful use of AI to improve clarity, speed, and quality of work.

What You'll Do

Reporting to the VP of Clinical Development, the Senior Medical Director will provide medical leadership for clinical studies in chronic hypoparathyroidism. This individual will drive clinical strategy and execution across the development lifecycle, ensuring patient safety, scientific rigor, operational excellence, and successful regulatory interactions. The ideal candidate is a collaborative physician leader with rare disease experience and a passion for improving patient outcomes.

Responsibilities

• Serve as the medical lead for one or more clinical programs, providing strategic and operational leadership across study design, execution, analysis, and reporting.
• Lead cross-functional clinical study teams and provide medical oversight to ensure participant safety, data quality, protocol compliance, and study interpretability.
• Partner with investigators, key opinion leaders, advocacy organizations, and CRO partners to execute high-quality clinical trials.
• Author and review protocols, investigator brochures, clinical study reports, DSURs, informed consent documents, and regulatory submission content.
• Lead medical monitoring activities and contribute to safety review meetings, investigator meetings, and regulatory authority interactions.
• Translate clinical, translational, and nonclinical findings into actionable development strategies and lifecycle plans.
• Represent Calcilytix at scientific congresses and maintain awareness of emerging developments in chronic hypoparathyroidism, endocrinology, and rare disease drug development.

Where You'll Work

This is a San Francisco/Bay Area-based role that will require periodic travel for investigator meetings, site visits, regulatory meetings, and scientific congresses.

Who You Are

• MD or equivalent medical degree required; board certification in Endocrinology, Nephrology, or a related specialty preferred.
• 5+ years of biotechnology, pharmaceutical, or clinical development experience with increasing medical leadership responsibilities.
• Experience in rare disease, endocrinology, metabolic disease, or chronic hypoparathyroidism drug development strongly preferred.
• Demonstrated expertise in clinical trial design, medical monitoring, protocol development, data interpretation, and regulatory interactions.
• Strong understanding of ICH-GCP, FDA, EMA, and global regulatory requirements.
• Exceptional communication, collaboration, and stakeholder management skills with the ability to influence across functions.
• Patient-focused, intellectually curious, and motivated to thrive in a fast-paced, mission-driven biotechnology environment.

At BridgeBio, we strive to provide a market-competitive total rewards package, including base pay, an annual performance bonus, company equity, and generous health benefits. Below is the anticipated salary range for candidates for this role who will work in California. The final salary offered to a successful candidate will depend on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience within the industry, educational background, location of residence and performance during the interview process. BridgeBio is a multi-state employer, and this salary range may not reflect positions based in other states.

Salary

$340,000 - $375,000 USD

As a global company, our comprehensive benefits may vary based on location. We have high expectations for our team members. We make sure those working hard for patients are rewarded and cared for in return.

For Full-Time U.S Based Roles:

Financial & Rewards

• Market-leading compensation
• 401(k) with employer match
• Employee Stock Purchase Program (ESPP)
• Pre-tax commuter benefits (transit and parking)
• Referral bonus for hired candidates
• Subsidized lunch and parking on in-office days

Health & Well-Being

• 100% employer-paid medical, dental, and vision premiums for you and your dependents
• Health Savings Account (HSA) with annual employer contributions, plus Flexible Spending Accounts (FSA)
• Fertility & family-forming benefits
• Expanded mental health support (therapy and coaching resources)
• Hybrid work model with flexibility
• Flexible, "take-what-you-need" paid time off and company-paid holidays
• Comprehensive paid medical and parental leave to care for yourself and your family

Skill Development & Career Paths:

• People are part of our growth and success story - from discovery to active drug trials and FDA pipelines, there are endless opportunities for skill development and internal mobility
• We provide career pathing through regular feedback, continuous education and professional development programs via LinkedIn Learning, LifeLabs, & BetterUp Coaching
• We celebrate strong performance with financial rewards, peer-to-peer recognition, and growth opportunities

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