Senior Director, Business Development

Reporting to the Chief Business Officer, the Senior Director, Business Development will play a central role in identifying, evaluating, negotiating, and executing strategic partnerships that strengthen Cabaletta Bio's leadership in engineered cell therapies for autoimmune diseases. Responsibilities: Business Development Strategy Identify and evaluate external opportunities including licensing, acquisitions, strategic collaborations, platform technologies, and co-development partnerships. Continuously assess the competitive landscape to identify emerging scientific and commercial opportunities aligned with Cabaletta's strategic priorities, including product expansion, geographic expansion, and lifecycle management strategies. Develop business development strategies that support both near-term pipeline expansion and long-term platform growth. Monitor industry trends, emerging technologies, financing activity, and M&A transactions to inform corporate decision-making. Opportunity Assessment Lead scientific, clinical, commercial, operational, intellectual property, and financial diligence for potential transactions. Build integrated commercial and financial models to evaluate strategic fit, market opportunity, probability-adjusted value, and return on investment. Prepare investment recommendations and executive-level presentations for the Executive Leadership Team and Board of Directors. Transaction Leadership Lead cross-functional transaction teams through all phases of partnering activities. Coordinate diligence efforts across Research, Clinical Development, Regulatory, CMC, Manufacturing, Commercial, Finance, Legal, and Intellectual Property. Support negotiation of confidentiality agreements, term sheets, licensing agreements, collaboration agreements, acquisition documents, and related contracts. External Relationship Management Develop and maintain relationships with biotechnology companies, academic institutions, CDMOs, and potential strategic partners. Represent Cabaletta at major partnering, investor, and scientific/medical conferences as well as industry meetings. Build a broad network across autoimmune disease, cell therapy, gene editing, in vivo engineering, and immunology ecosystems. Alliance Management Serve as the primary business lead for strategic collaborations and licensing partnerships following transaction execution, ensuring alignment with Cabaletta's strategic and operational objectives. Build and maintain productive relationships with external partners, fostering transparency, trust, and effective governance throughout the lifecycle of each alliance. Participate/co-lead in Joint Steering Committees (JSCs), Joint Development Committees (JDCs), and other governance bodies, coordinating internal cross-functional participation and decision-making. Monitor alliance performance, contractual obligations, key milestones, financial commitments, and governance deliverables to ensure successful execution of partnership objectives. Collaborate closely with Research, Clinical Development, Technical Operations, Regulatory, Commercial, Finance, Legal, and Executive Leadership to proactively identify and resolve issues that may impact partnership success. Support amendments, expansions, and new strategic opportunities within existing collaborations, identifying ways to maximize long-term value for both Cabaletta and its partners. Ensure effective communication between internal stakeholders and external collaborators while serving as a trusted ambassador for Cabaletta in all partnership interactions. Qualifications: