Sign upLog in
JobsJobs in CaliforniaJobs in South San Francisco, CAEngineering and Technology JobsScience Jobs

Scientist I

Compass Consulting

South San Francisco, CA

Apply
JOB DETAILS
SKILLS
Analysis Skills, Assays, Biotech and Pharmaceutical, Cell Analysis, Communication Skills, Cross-Functional, Data Sets, Disease, Documentation, Drug Development, Drug Discovery, Experiment Design, Eye Diseases/Disorders, Medical Conditions, Medical Products, Medical Treatment, Medicine, Problem Solving Skills, Publications, Pulmonary Disease, Risk Analysis, Sales Pipeline, Scientific Publications, Standard Operating Procedures (SOP), Team Player, Technical Support, Translational Research
LOCATION
South San Francisco, CA
POSTED
30+ days ago
Our client is a leading biotechnology company that discovers, develops, manufactures and commercializes medicines to treat patients with serious or life-threatening medical conditions. They are among the world's leading biotech companies, with multiple products on the market and a promising development pipeline.

The Position:

The Complex in Vitro Systems (CiS) Lab within the Department of Translational Safety is seeking a highly motivated Scientist to develop, characterize, and qualify advanced complex in vitro models to support its mission of delivering safe and efficacious medicines. The CiS group partners closely with colleagues across Development Sciences, Translational Medicine, and Research to establish and implement innovative platforms that enable target assessment, lead optimization, and safety evaluation across a dynamic portfolio, novel modalities, and emerging therapeutic areas.

In this lab-based role, you will provide scientific and technical expertise to support the development and implementation of human lung complex in vitro models (CIVM), including lung organoids, air-liquid interface (ALI) cultures, and lung micro physiological systems for drug development. Responsibilities include culturing and characterizing state-of-the-art lung CIVM models, designing and executing model qualification and characterization studies (e.g., advanced imaging, transcriptomics, and functional and phenotypic assays), analyzing and interpreting complex datasets, and maintaining rigorous, high-quality documentation. The Scientist will be expected to share scientific insights across functional teams, contribute to cross-disciplinary collaborations, and support internal and external publication efforts.

This position is ideal for an experienced scientist passionate about advancing disease modeling and translational safety through innovative complex in vitro. The successful candidate will excel in a dynamic, collaborative research environment, demonstrate exceptional problem-solving skills, and effectively communicate across scientific disciplines to contribute to the development of cutting-edge ocular disease models and help shape the future of ocular drug discovery and development.

The Opportunity:
  • Development, qualification, and implementation of innovative in vitro lung model systems (e.g., airway and alveolar organoids, ALI cultures, lung-on-a-chip co-culture platforms) to support disease modeling and lung safety risk assessment.
  • Designing and executing experiments to characterize lung models, including evaluation of cell viability, morphology, and barrier integrity and function, using techniques such as cytotoxicity assays, confocal and high-content imaging, transepithelial resistance/permeability assays, and transcriptomic and proteomic analyses.
  • Collaborating closely with cross-functional teams within and outside gRED to align on complex model building with therapeutic strategies and program needs.
  • Analyzing, interpreting, and clearly communicating study results to collaborators and stakeholders, and contributing to internal and external scientific presentations as appropriate.
  • Maintaining comprehensive electronic documentation in accordance with departmental Standard Operating Procedures (SOPs) and contributing to study reports, safety assessments, and final deliverables.

About the Company

C

Compass Consulting

Similar Job Searches

Analytical Scientist Jobs in South San Francisco, CABiological Scientist Jobs in South San Francisco, CAClinical Scientist Jobs in South San Francisco, CAComputer Scientist Jobs in South San Francisco, CAData Scientist Jobs in South San Francisco, CADirector Of Research And Development Jobs in South San Francisco, CADirector Of Research Jobs in South San Francisco, CAMedical Scientist Jobs in South San Francisco, CAMolecular Biology Scientist Jobs in South San Francisco, CAProduct Development Scientist Jobs in South San Francisco, CA