Research Assistant | Laboratory of Systems Cancer Biology

Rockefeller University

New York, New York

JOB DETAILS
SALARY
SKILLS
Analysis Skills, Analysis Software, Assays, Biochemistry, Biology, Breast Cancer, Cancer, Cell Cultures, Colon Cancer, Communication Skills, Data Analysis, Detail Oriented, Diversity, Establish Priorities, Genomics, Genotyping, Implants, Inventory Management, Laboratory, Laboratory Operations, Laboratory Techniques, Molecular Biology, Operational Support, Organizational Skills, Presentation/Verbal Skills, Quality Control, R Programming Language, Real-time PCR (qPCR), Record Keeping, Regulations, Ribonucleic Acid (RNA), Small Molecules, Specimen Collection, Team Player, Writing Skills
LOCATION
New York, New York
POSTED
10 days ago
Organization Overview: Cancer remains a daunting problem despite decades of active research into its molecular causes. Such studies have predominantly focused on the earliest stages of cancer progression, such as the formation of a cancer or genes involved in the growth of the primary tumor. In humans afflicted by cancer, the primary tumor is typically surgically resected or eliminated by radiation. Vast numbers of patients, nonetheless, die of cancer as a result of metastasis or the spread of cancer cells from the primary tumor site to distal organs. This process is, in fact, the overwhelming cause of death from cancer, and its occurrence changes a patient's prognosis to incurable. Despite its vast clinical significance and inherently fascinating underlying biology, the metastatic program is poorly understood both at the molecular level and at the cellular/tissue micro-environment levels. Our laboratory employs a multi-disciplinary approach involving molecular, biochemical, computational, imaging, and clinical association methods to characterize the critical regulatory pathways that mediate the steps of this process. By implanting human cancer cells obtained from patients with breast or colon cancer into recipient mice, we study and interfere with the various stages of metastasis. By comparing human cancer cells that are highly metastatic to those that fail to metastasize, we have uncovered a set of small RNA molecules (microRNAs) that suppress metastasis. Our future work is aimed at gaining a better understanding of the mechanisms by which these microRNAs block metastasis. Our hope is that a better understanding of this process will enhance our therapeutic arsenal against it.  Overview:

The Tavazoie Lab at the Rockefeller University is looking for a highly motivated, detail-oriented Research Assistant to join our efforts to study the basic principles of cancer metastasis, genomics and gene regulation in cancer. As a research assistant you will be trained in a broad range of in vitro, in vivo and in silico experimental techniques to support collaborative research projects. The successful candidate will play an active role in experimental execution, data generation, and quality control, working closely with a senior scientist. 

Responsibilities:

Responsibilities include:

  • Maintain cell cultures and perform cell based in vitro assays
  • Perform molecular assays including but not limited to protein and RNA analysis, qPCR, W-blots, ELISA and library preparation
  • Maintain mice colonies including genotyping and breeding
  • Perform tumor growth studies in mouse models, administration of test articles, sample collection and tissue processing
  • Learn and assist in analyzing sequencing data using established pipelines
  • Maintain detailed experimental records of laboratory procedures and results
  • Assist and collaborate with internal and external researchers in interpretation of the data
  • Support general lab operations, including reagent management, ordering and the generation and maintenance of lab inventories
  • Participate actively in lab meetings and scientific discussions

The successful applicant will be part of a fast-paced and dynamic research team. The Tavazoie Lab will provide significant on-the-job training and supervision. We seek a candidate who is motivated and can take independent initiative. This is an excellent opportunity for someone looking to gain experience to move into a PhD or MD-PhD program within a couple of years, based on the new skillset they develop at The Rockefeller University.

Qualifications:

REQUIRED QUALIFICATIONS:

  • BS or MS degree in Biology, Biochemistry, or related field
  • Strong organizational skills and attention to detail
  • Ability to work both independently and collaboratively in a fast-paced research setting
  • Clear communication skills and a high level of scientific integrity
  • Team-oriented with excellent written and verbal communication skills, collaboration skills and an eagerness to learn
  • Basic experience with standard and/or advanced data analysis software tools (Excel, R, or similar)

 

PREFERRED QUALIFICATIONS:

  • Prior laboratory experience and demonstrated familiarity with basic molecular biology techniques
  • Experience with RNA isolation and tissue culture
  • Familiarity with handling research animals (mice)

COMPETENCIES:

  • Technical and Professional Skills: Consistently demonstrates knowledge relevant for current role; strives to expand the depth and breadth of technical and professional skills; works with a high level of integrity; exhibits focus and discipline; appropriately prioritizes, manages expectations and delivers on commitments.
  • Collaborative & Communicative: Models collaboration and teamwork; brings out the best in others; effectively works with all levels, internally and externally; respects and embraces diversity of perspective; communicates clearly and listens carefully; uses good judgment as to what to communicate and when to do so.
  • Adaptable & Innovative: Adaptable and embraces change; develops new insights and pursues improvements and efficiency; fosters exchange of new ideas and willing to challenge the status quo; takes initiative and is solution-oriented; engages in work with passion and curiosity.

 

 

The Rockefeller University is an equal opportunity employer – veterans/individuals with disabilities. Qualified applicants will receive consideration for employment without regard to characteristics protected by applicable local, state or federal law, including but not limited to disability and protected veteran status.

 

The salary of the finalist selected for this role will be set based on various factors, including but not limited to organizational budgets, qualifications, experience, education, licenses, specialty, and training. The hiring range provided represents The Rockefeller University's good faith and reasonable estimate of the range of possible compensation at the time of posting.

Compensation Range: Min: USD $50,000.00/Yr. Compensation Range: Max: USD $55,000.00/Yr.

About the Company

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Rockefeller University

Founded by John D. Rockefeller, the Rockefeller Institute for Medical Research was incorporated on June 14, 1901. It was the first institution in the United States devoted solely to biomedical research--to understanding the underlying causes of disease.

Today, renamed Rockefeller University, it is one of the foremost research centers in the world, contributing to 23 Nobel Prizes as well as numerous other awards.

Rockefeller University Community
  • 71 heads of laboratories
  • 200 research and clinical scientists
  • 350 postdoctoral investigators
  • 1,050 support staff
  • 150 Ph.D. students
  • 50 M.D.-Ph.D. students
  • 887 alumni
Areas of basic interdisciplinary research
  • biochemistry, structural biology and chemistry
  • molecular, cell and developmental biology
  • immunology, virology and microbiology
  • medical sciences and human genetics
  • neuroscience
  • physics and mathematical biology
Revolutionary accomplishments

Rockefeller University researchers achieved many of the last century's seminal advances in the biomedical sciences, including:
  • Discovering that DNA is the basic material of heredity (1944)
  • Determining that cancer can be caused by a virus (1911)
  • Confirming the connection between cholesterol and heart disease (1950s)
  • Developing methadone maintenance for people addicted to heroin (1960s)
  • Developing the AIDS "cocktail" drug therapy (1990s)
Seventy-four laboratories form the university's core
The university's laboratory-based organizational structure "without walls" and pared-down layers of administration do away with the schools and academic departments that too often separate scientists. "This approach fosters a tremendously rich soup of interdisciplinary research and collaboration," says Rockefeller professor and Nobel laureate Günter Blobel.

Acclaimed scientists
In its history, Rockefeller has been associated with 23 Nobel laureates and 19 Lasker Award recipients. Five faculty members have been named MacArthur Fellows and 12 have garnered the National Medal of Science, the highest science award given by the United States. And, 33 Rockefeller faculty are elected members of the National Academy of Sciences.

Partnerships with other leading institutions
Rockefeller has close ties with neighboring Weill Medical College of Cornell University, New York-Presbyterian Hospital and Memorial Sloan-Kettering Cancer Center. Additional academic partnerships with the Courant Institute of New York University and Bard College provide students with a rich array of training opportunities. Rockefeller forges collaborations with biotech and pharmaceutical companies as needed to speed research findings into development to improve patient care.

Clinical research hospital
In 1910, Rockefeller scientists founded the nation's first hospital devoted exclusively to experimental medicine. The Rockefeller University Hospital's only patients are participants in clinical trials building on basic research findings from Rockefeller labs. This "allows the university to maintain an unbroken spectrum of research, from basic to clinical," says Joshua Lederberg, Nobel laureate and Rockefeller president emeritus. Unburdened by constraints of standard patient care, the hospital is a vital component of Rockefeller's commitment to accelerating basic research findings on their route from bench to bedside for the diagnosis, treatment and prevention of disease. Studies are under way on AIDS/ HIV, obesity, hepatitis C and addictive diseases.

More than science
Artistic and intellectual activity flourishes on Rockefeller's campus. The verdant grounds, situated on Manhattan's Upper East Side, boast a world-class art collection. The university regularly hosts events designed to explore the intuitive connection between science and the arts.Weekly and monthly recital series grace the university's spectacular auditorium, and a variety of exhibits regularly take shape on campus -currently including sculpture on temporary exhibition from New York's Museum of Modern Art.

Select graduate student body
A class of Ph.D. and M.D.-Ph.D. students from across the United States and the world works closely with international faculty in a rigorous, highly personalized program of graduate study and research. The university offers graduate students access and opportunities to work with leading scientists, as well as full financial support and affordable on- and off-campus housing.

University budget
Funding the research studies of The Rockefeller University's scientists are the National Institutes of Health and other government agencies, Howard Hughes Medical Institute, private gifts and endowment income.

COMPANY SIZE
2,500 to 4,999 employees
INDUSTRY
Education
FOUNDED
1901
WEBSITE
http://www.rockefeller.edu/