Principal Scientist, Process Chemistry

Pfizer

Bothell, WA

Apply

JOB DETAILS

SALARY

$106,000–$176,600 Per Year

SKILLS

Analysis Skills, Analytical Chemistry, Analytical Development, Antibodies, Biotech and Pharmaceutical, Campaigns, Cancer, Chemical Engineering, Chemical Processes, Chemistry, Clinical Support, Clinical Trial, Communication Skills, Conferences, Contract Research Organization (CRO), Cross-Functional, Data Analysis, Drug Development, Environmental Regulations, Federal Laws and Regulations, GMP (Good Manufacturing Practices), Government, Healthcare Providers, High Throughput, Incentive Programs, Leadership, Leading Edge Technology, Manufacturing, Mathematics, Medical Products, Mentoring, Modality, Oncology, Organic Chemistry, Patent Statutes, Patents, Pharmacovigilance, Policy Implementation, Pre-Clinical Development, Presentation/Verbal Skills, Process Capability, Process Development, Publications, Regulations, Research & Development (R&D), Resource Management, Safety/Work Safety, State Laws and Regulations, Team Player, Technical Leadership, Technical Strategy, Wheel/Front-End Loader, Willing to Travel, Writing Skills

LOCATION

Bothell, WA

POSTED

13 days ago

**OVERVIEW:** Pfizer's purpose is to deliver breakthroughs that change patients' lives. Process Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world. **ROLE SUMMARY:** The Chemical Process and Analytical Development (CPAD) group located in Bothell, WA is responsible for the development of chemical processes and analytical methods for novel drug-linkers (linker-payloads) used in antibody-drug conjugates (ADCs). Our process chemists, analytical chemists, and chemical engineers collaborate to discover phase-appropriate synthetic routes and chemical processes to accelerate the delivery of life saving medicines to patients, and to develop robust and innovative synthetic processes to novel commercial drug-linker candidates that drive the next generation of targeted cancer therapy. As a Principal Scientist in CPAD, you will provide technical leadership to a team of process chemists engaged in route screening/selection, process development, and process characterization for our growing drug-linker portfolio. You will drive the development of safe and scalable chemistry by leveraging state-of-the-art technologies such as high-throughput experimentation, data-rich experimentation, catalysis, continuous processing, and predictive technologies. You will spearhead the advancement of Pfizer's oncology portfolio through personal laboratory effort as well as oversee external resources through technology transfer and campaign execution at CDMOs. You will serve as a technical and strategic leader for early and late-phase programs while mentoring junior staff members in a supportive and inclusive work environment. You will propose technical and strategic solutions to management and represent process chemistry in cross-functional teams requiring excellent communication skills. Finally, you will be expected to establish an external presence as technical leader in the field by authoring journal articles and presenting at leading external scientific meetings. **ROLE RESPONSIBILITIES:** + Design and execute well-planned laboratory experiments that require complex data analysis. + Maintain high standards for all laboratory records, reports, patents, regulatory documents, and external communications. + Employ state-of-the art technologies including high-throughput experimentation, data-rich experimentation, computational tools, and predictive software to accelerate process development. + Be recognized as a technical leader internally and externally by authoring publications and presenting externally. + Drive technical aspects of early and late phase pharmaceutical development. + Lead technology transfer to internal sites or external CDMOs for GMP manufacturing while managing CRO/CMO resources. + Persuasively communicate abstract concepts, ideas, and solutions to project teams, leadership, and cross-functional teams. + Establish and deliver on tight timelines aligned with our portfolio goals. + Promote a supportive and inclusive work environment and mentor junior staff. + Maintain an understanding of the activities and research carried out by the project team members. + Lead authoring for patents and regulatory documents. + Leverage knowledge and experience to guide cross-functional team decisions. + Build strong relationships with stakeholders to advocate for our department. **BASIC QUALIFICATIONS:** + PhD in Organic Chemistry with 4+ years of experience in pharmaceutical process development, including route design, scale-up, and GMP manufacturing; or a Master's degree with 9+ years of relevant experience OR Bachelors degree and 12+ years of experience. + Proven track record of scientific innovation and impact, demonstrated through authorship of peer-reviewed publications, patents, or presentations at recognized scientific conferences. + A sound understanding of modern synthetic organic chemistry principles, process development, engineering, analytical and purification technologies. + Excellent written and oral communication skills, with a demonstrated ability to effectively collaborate with stakeholders. + In-depth knowledge of pharmaceutical development from pre-clinical to commercialization. + Experience in a regulated pharmaceutical environment including GMP deliveries and regulatory authoring. + This is an on-site designated role, and you will be expected to work five days per week on-site. **PREFERRED QUALIFICATIONS:** + Experience with drug-linkers for ADCs or other targeted mixed-modality therapeutics. + Experience in mentoring scientific staff, both directly and in a matrix environment. + Experience with technology transfer activities and CRO/CDMO resource management. **PHYSICAL/MENTAL REQUIREMENTS:** + Lifting, sitting, standing, walking, bending and ability to perform mathematical calculations. **NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS:** + This is a laboratory-based position. Adherence to safe work practices, including the use of personal protective equipment (PPE) such as safety glasses, lab coats, and gloves, is required. Occasional travel for business purposes, scientific conferences, or collaboration (typically < 10%) is expected. **Additional Job Details:** + Work Location Assignment: **On Premise** + Last date to apply is June 23, 2026 The annual base salary for this position ranges from $106,000.00 to $176,600.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States. Relocation assistance may be available based on business needs and/or eligibility. Candidates must be authorized to be employed in the U.S. by any employer. U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future. **Sunshine Act** Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. **EEO & Employment Eligibility** Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States. Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email disabilityrecruitment@pfizer.com. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned. To learn more about acceptable and prohibited uses of AI during the recruitment process, please review our candidate AI-use guidelines available on Pfizer Careers. Research and Development

About the Company

Pfizer

A career at Pfizer offers opportunity, ownership and impact. All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

COMPANY SIZE

5,000 to 9,999 employees

INDUSTRY

Other/Not Classified

FOUNDED

1849

WEBSITE

http://www.pfizer.com