Postdoctoral Research Fellow, Anesthesiology

Department:

37713 Wake Forest University Health Sciences - Anesthesiology

Status:

Full time

Benefits Eligible:

Yes

Hours Per Week:

40

Schedule Details/Additional Information:

full-time

Pay Range

$30.70 - $46.05

This Postdoctoral Fellow position is essential for the successful execution of a highly technical, multi aim translational research project focused on uncovering immune mechanisms underlying chemotherapy induced peripheral neuropathy (CIPN) in the context of breast cancer treatment. The proposed research integrates complex orthotopic tumor models, immune specific genetic manipulations, advanced neurobehavioral phenotyping, and translational pharmacologic interventions, all of which require a dedicated, full time postdoctoral scientist with advanced methodological and analytical expertise. PhD or equivalent required.

Scope of the Position and Key Functions

The Postdoctoral Fellow will serve as the primary experimental lead and integrator across all three Specific Aims of the project, with responsibilities including but not limited to:

1. Experimental Design and Execution

• Lead and coordinate immunocompetent, orthotopic breast cancer resection models combined with adjuvant chemotherapy.
• Execute complex longitudinal CIPN behavioral assays (mechanical allodynia, cold sensitivity).
• Perform immune specific genetic and pharmacologic manipulations targeting the IRE1 XBP1 pathway.
• Conduct advanced flow cytometry, FACS sorting, molecular assays (qPCR, ELISA), histology, and confocal imaging.

2. Mechanistic and Translational Integration

• Integrate tumor progression endpoints (recurrence, lung metastases, IVIS imaging) with neurotoxicity and immune outcomes.
• Perform ex vivo co culture assays linking immune cell activation to neuronal injury and tumor aggressiveness.
• Evaluate translational pharmacologic strategies (MKC 8866 ± paclitaxel) across multiple disease contexts.

3. Data Analysis, Interpretation, and Dissemination

• Analyze high dimensional data across behavioral, molecular, immune, and oncologic endpoints.
• Prepare manuscripts, conference presentations, and progress reports for funding agencies.
• Contribute to grant development supporting continuation and expansion of the research program.

4. Research Training and Mentorship

• Provide day to day mentorship to trainees (graduate students and research staff) in specialized techniques.
• Foster cross disciplinary collaboration between cancer biology, immunology, neuroscience, and anesthesiology.

Our Commitment to You:

Advocate Health offers a comprehensive suite of Total Rewards: benefits and well-being programs, competitive compensation, generous retirement offerings, programs that invest in your career development and so much more - so you can live fully at and away from work, including:

Compensation

• Base compensation listed within the listed pay range based on factors such as qualifications, skills, relevant experience, and/or training

• Premium pay such as shift, on call, and more based on a teammate's job

• Incentive pay for select positions

• Opportunity for annual increases based on performance

Benefits and more

• Paid Time Off programs

• Health and welfare benefits such as medical, dental, vision, life, and Short- and Long-Term Disability

• Flexible Spending Accounts for eligible health care and dependent care expenses

• Family benefits such as adoption assistance and paid parental leave

• Defined contribution retirement plans with employer match and other financial wellness programs

• Educational Assistance Program

Note: Eligibility for programs listed above may depend on your FTE or status (e.g., full-time, part-time, per diem, temporary, etc.); please ask a Recruiter for more information during an interview.

About Advocate Health

Advocate Health is the third-largest nonprofit, integrated health system in the United States, created from the combination of Advocate Aurora Health and Atrium Health. Providing care under the names Advocate Health Care in Illinois; Atrium Health in the Carolinas, Georgia and Alabama; and Aurora Health Care in Wisconsin, Advocate Health is a national leader in clinical innovation, health outcomes, consumer experience and value-based care. Headquartered in Charlotte, North Carolina, Advocate Health services nearly 6 million patients and is engaged in hundreds of clinical trials and research studies, with Wake Forest University School of Medicine serving as the academic core of the enterprise. It is nationally recognized for its expertise in cardiology, neurosciences, oncology, pediatrics and rehabilitation, as well as organ transplants, burn treatments and specialized musculoskeletal programs. Advocate Health employs 155,000 teammates across 69 hospitals and over 1,000 care locations, and offers one of the nation's largest graduate medical education programs with over 2,000 residents and fellows across more than 200 programs. Committed to providing equitable care for all, Advocate Health provides more than $6 billion in annual community benefits.