Postdoc fellows in cancer immunology and cardiovascular biology

University of Pennsylvania

Philadelphia, PA

JOB DETAILS
SKILLS
Adobe Acrobat, Adobe Flash, Analysis Skills, Bioinformatics, Biology, Cancer, Cardiology, Cardiovascular, Cell Biology, Disease, Experiment Design, Immunology, Ischemia, Medicine, Mentoring, Molecular Analysis, Molecular Biology, Proteomics, Publications, Python Programming/Scripting Language, R Programming Language, Radiation Therapy, Scientific Research, Strategic Planning, Team Player
LOCATION
Philadelphia, PA
POSTED
3 days ago


The Fan Laboratory in the Department of Radiation Oncology at the University of Pennsylvania''s Perelman School of Medicine is recruiting creative, collaborative, and highly motivated Postdoctoral Scientists to lead research projects in cancer immunology and cardiovascular biology.



Our lab investigates how the tissue microenvironment regulates cancer immunity and heart repair. We are particularly interested in:





+ The molecular mechanisms underlying vascular control of immune cell function in cancer and ischemic heart disease;



+ Targeting myeloid cells to overcome cancer-associated immunosuppression;



+ The biology and therapeutic targeting of γδT cell and NKT cell exhaustion in cancer;



+ Advanced radiation strategies, including FLASH and SFRT, to modulate tissue immunity in tumors and normal hearts.





Our research integrates mouse models, quantitative molecular and cell biology, immunology, metabolism, and multi-omics approaches—including transcriptomics, epigenomics, and proteomics—as well as advanced 3D imaging to uncover molecular pathways and develop novel therapeutic strategies. https://www.med.upenn.edu/apps/faculty/index.php/g20002840/p8679288.



Projects will be tailored to the interests of the successful candidate within broadly defined research themes, including:

• Molecular communication among endothelial cells, fibroblasts, macrophages, and dendritic cells

• Metabolic and transcriptional mechanisms regulating γδT cell dysfunction in the tumor microenvironment

• Combinatorial strategies integrating CAR-T cell therapy with FLASH- and SFRT-based radiotherapy

• Targeting endothelial plasticity and myeloid cell transitions to improve cardiac repair following ischemia



The Fan Lab emphasizes rigorous science, intellectual independence, and strong mentorship, supporting career trajectories with a strong track record of trainees advancing to independent faculty positions.



Required Qualifications

• PhD in Cancer Biology, Immunology, Cell Biology, or a related field

• Demonstrated research productivity, including first-author primary research publications

• Strong experimental and analytical skills in molecular, cellular, or tissue biology

• Ability to independently design and execute experiments



Preferred Qualifications

• Experience working with mouse models

• Background in metabolism and/or immunological analysis

• Experience in cancer and/or cardiovascular research workflows

• Bioinformatics skills (e.g., R, Python, or related tools)







Candidates requiring visa sponsorship are welcome to apply



To apply, please submit:





+ a curriculum vitae,



+ a cover letter describing their research experience and interests



+ a PDF of relevant publication(s)



+ contact information for three references





Any questions can be directed to Dr. Yi Fan (fanyi@upenn.edu)




The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state, or local law.

About the Company

U

University of Pennsylvania

Penn's beautiful urban campus provides easy access to a range of educational, cultural, and recreational activities. We offer excellent healthcare and tuition benefits for you and your family, as well as generous retirement benefits, professional development opportunities and flexible work options. Penn is a diverse, multicultural learning community at the cutting edge of research and information technology. Click here to read more about why we're a Best Employer. Not only does Penn offer a unique environment within the city of Philadelphia to work, we also provide a wide array of employee benefits. From a competitive retirement program and comprehensive health care options to health promotion and wellness services and tuition assistance, there's a wealth of opportunities and resources available to you at Penn.

Penn is frequently cited as an outstanding employer:

  • Recipient of the 2010 Terri Lynne Lokoff Child Care Foundation Corporate Leadership Award for commitment to supporting worklife balance programs.
  • Selected as a recipient of the 2010 Healthy Workplace Award by the Philadelphia Business Journal and presenting sponsor UnitedHealthcare
  • Recognized as a 2010 Top Workplace by The Philadelphia Inquirer/Daily News.
  • Recipient of the 2009 Vision Award for commitment to workforce diversity and economic inclusion.
  • Selected for Computerworld's 100 Best Places to Work in IT six years in a row!
  • Recognized by the Delaware Valley Association for the Education of Young Children as a 2006 Best Employer for Working Parents
  • Named a Best Place to Work in the November 2007 issue of Philadelphia Magazine.
  • Designated a Best Workplace for Commuters by the National Center for Transit Research
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1990
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