Oligonucleotide Scientist

Oligonucleotide Scientist

Advance the next generation of RNAi therapeutics! Join an innovative drug discovery team developing cutting-edge oligonucleotide therapies that have the potential to transform treatments for neuroscience, immunology, and oncology. If you're passionate about oligonucleotide synthesis, nucleic acid chemistry, and translating innovative science into life-changing therapies, we'd love to hear from you!

Our client, a leading biotech organization based in South San Francisco, CA, has a contract opening for an Oligonucleotide Scientist. In this high-impact role, you will work in an oligonucleotide therapeutic drug discovery research lab and interface across different therapeutic areas, including neuroscience, immunology, and oncology, to help build a comprehensive therapeutic discovery strategy.

Important Details:

• 6-month contract opportunity with possibility to extend
• South San Francisco, CA- Fully Onsite (5 days/week)
• Monday-Friday (40 hours/week)
• Pay rate range approved: $45-52/HR, depending on experience

Job Description:

• We are looking for a candidate with experience in oligonucleotide discovery and synthesis to support our new oligonucleotide therapeutics discovery group.
• Experience in delivery of oligonucleotide therapeutics and large molecule drug discovery would be preferred.
• The successful candidate will join an interdisciplinary chemistry team working in RNAi biology research and will contribute positively to its developing culture.

Responsibilities:

• The candidate will work in an oligonucleotide therapeutic drug discovery research lab and interface across different therapeutic areas, including neuroscience, immunology, and oncology, to help build a comprehensive therapeutic discovery strategy.
• A good understanding and troubleshooting experience in oligonucleotide synthesis and impurity profiling is a plus.
• Collaborate with other scientists to maintain common lab equipment such as oligo synthesizers, HPLC, and desalting units.
• Perform literature reviews, propose and execute nucleic acid chemistry plans, and coordinate chemistry and biology data to support oligonucleotide compound progression.
• Establish methods for scaled-up synthesis of lead molecules and coordinate material delivery for preclinical studies.
• Maintain a high level of productivity in the laboratory setting to meet the timelines for in vitro and in vivo studies.

Minimum candidate qualifications and experience:

• The candidate must have hands-on experience in oligonucleotide synthesis using automated oligo synthesizers, Client nucleic acid chemistry, oligonucleotide purification, and characterization using HPLC and mass spectrometry.
• The qualified individual will possess a BS/MS in Organic Chemistry or related discipline.
• Pharmaceutical or biotechnology industry experience in research and development of RNAi therapeutics is preferred.
• A good understanding of nucleic acid therapeutic modalities, modification chemistries, sequence selection, and mechanism of action is preferred
• Relevant experience in oligonucleotide therapeutics, large molecule drug discovery, oligonucleotide delivery, or bio-conjugation is desirable.
• Good communication and interpersonal skills are essential and will be evaluated during the interview process.
• The ideal candidate should be highly motivated and have strong problem-solving, analytical, communication, and organizational skills.
• Applicants must be authorized to work in the United States.

APPLY NOW!

Pride Health and it's affiliates offers eligible employee's comprehensive healthcare coverage (medical, dental, and vision plans), supplemental coverage (accident insurance, critical illness insurance and hospital indemnity), 401(k)-retirement savings, life & disability insurance, an employee assistance program, legal support, auto, home insurance, pet insurance and employee discounts with preferred vendors.

Equal Employment Opportunity:

Pride Health is an equal opportunity employer. We do not discriminate on the basis of the race, religious creed, color, national origin, ancestry, physical disability, mental disability, reproductive health decision making, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, age, sexual orientation, veteran or military status, or any other characteristic protected by applicable federal, state, or local law.

Fair Chance Employment:

Pride Health is a Fair Chance employer. We consider all qualified applicants, including those with criminal histories, in a manner consistent with applicable state and local Fair Chance laws and ordinances, including, the California Fair Chance Act and all applicable local Fair Chance ordinances.

Accommodations:

We are committed to providing reasonable accommodations to applicants and employees with disabilities. If you require a reasonable accommodation to participate in the application or interview process, or to perform the essential functions of this role, please contact us.

Only applicable for San Francisco Candidates:

Under the San Francisco Lactation in the Workplace Ordinance, we will provide written notice of lactation accommodation rights, and this notice will automatically be given upon hiring, any inquiry of parental leave or lactation accommodation.

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