Medical Research Tech III

915044No5625414010.00.005/28/2026Medical Research Tech IIITexas Tech Unv Hlth Sci Ctr El Paso Employees in this classification provide support in an assigned research laboratory conducting specified phases of research projects. Performs work independently and is responsible for developing new procedures and techniques to be utilized in the laboratory and in experiments, and new applications for standard procedures and techniques. Work is performed under usual laboratory conditions. Some hazards may be present due to use of radioactive, carcinogenic or other potentially harmful substances. Responsibilities also include ensuring overall cleanliness of the laboratory and laboratory equipment, and ordering and maintaining an adequate stock of necessary supplies. May instruct or direct work of subordinate laboratory personnel. Supports translational and preclinical research projects in oncology drug discovery and therapeutic development. The lab investigates small-molecule and peptide-based modulators targeting oncogenic signaling pathways, tumor microenvironment, hormone resistance, and immune evasion. Plays a key role in the design, execution, and analysis of molecular and in vivo studies evaluating lead compounds across solid tumor models.44952BRUp to 25%

• Conduct western blotting, ELISA, and immunoprecipitation assays to study drug-target engagement and pathway inhibition. Perform RNA/protein isolation, qRT-PCR, cloning, mutagenesis, and transient/stable gene manipulation in cancer cell lines. Culture 2D and 3D cancer spheroid models, including lentiviral/siRNA-mediated knockdowns and drug synergy studies.
• Conduct immunofluorescence staining and digital imaging using confocal microscopy to assess subcellular localization and phenotypic markers.
• Perform live-cell imaging and apoptotic/mitotic readouts (Annexin V, TUNEL, Ki-67, H2AX, etc.).
• Assist in establishing xenograft, syngeneic, and orthotopic tumor models for breast, ovarian, pancreatic, and glioma studies. Conduct drug administration (IP/SC/PO), tumor measurement, survival tracking, necropsy, tissue collection, and histological preparation. Support pharmacokinetic/pharmacodynamic (PK/PD) sample processing and biomarker evaluation.
• Maintain cell line inventory, animal colony genotyping, reagent preparation, and equipment calibration. Guide junior lab members in standard operating procedures and contribute to manuscript and figure preparation. Uphold lab safety, IACUC, and biosafety protocols.
• Remains current with all licensure, certifications and mandatory compliances and trainings required of this position.
• Adhere to all policies, procedures and practices (Regents Rules, TTUS, HSECEP OPs, etc.).
• Personally, and consistently, demonstrate, display and act in accordance with Texas Tech Health El Paso's Values (Service, Respect, Accountability, Integrity, Advancement, and Teamwork). Serve as a Value''s leader while actively promoting and encouraging staff across the institution.
• Performs all other duties as assigned.

No Compensation is commensurate upon the qualifications of the individual selectedHourly El Paso

• Laboratory experience, ideally in a translational oncology or therapeutic development setting.
• Proficiency in mammalian cell culture, western blotting, nucleic acid analysis, and fluorescence microscopy.
• Willingness and eligibility to work with mouse tumor models and BSL-2 viral vectors.
• Experience with targeted therapy or drug resistance models (e.g., GR antagonists, Midkine inhibitors, LIFR pathway).
• Familiarity with survival surgery for PDX or syngeneic tumor implantation and IVIS/bioluminescence imaging.
• Skilled in scientific software (ImageJ/Fiji, GraphPad Prism, Adobe Illustrator, FlowJo).
• Strong organizational and data management skills with attention to reproducibility and rigor.

HSC - El Paso Molecular and Trans Medicine Resume / CV, TranscriptFull Time Compensation is commensurate upon the qualifications of the individual selected and budgetary guidelines of the hiring department, as well as, the institutional pay plan. For additional information, please reference the institutional pay plan on the Human Resources webpage.Research Technicians DayAll qualified applicants will be considered for employment without regard to sex, race, color, national origin, religion, age, disability, protected veteran status, or genetic information.

• Bachelor''s degree in one of the sciences, or equivalent combination (four (4) years) of job-related experience and college education.
• Experience may be substituted for college education on a year for year basis.

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