Lead UX Designer

A Rare Opportunity to Shape the Future of Genomics

Join a team of brilliant, passionate innovators determined to transform healthcare. At BillionToOne, we''ve built a category-defining, publicly traded company on Nasdaq where transparency fuels trust, collaboration drives breakthroughs, and every contribution moves the needle on our mission to make life-changing diagnostics accessible to all. We don''t just aim for incremental improvements; we build products that are 10x better than anything that exists today.

Our scientists, engineers, sales executives, and visionaries are united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion, and every innovation you contribute helps remove the fear of the unknown from some of life''s most critical medical moments.

If you''re driven by purpose, energized by innovation, and ready to help shape the future of precision medicine at scale, this is where you belong.

We''re seeking an exceptional Lead UX Designer to own the end-to-end experience strategy and execution for our prenatal diagnostic platform, Unity. This role sits at the intersection of cutting-edge genomics and human-centered design - leading the translation of complex molecular diagnostics into seamless, trustworthy experiences that empower clinicians, patients, and operational teams.

As a key member of our product team, you''ll lead design from strategic insights through final production, applying systems thinking to design across an interconnected healthcare ecosystem that spans lab processes, electronic health records, provider networks, and patient touchpoints. You''ll bridge scientific complexity and clinical reality while guiding design team members and elevating the craft of the entire organization. This is a hybrid position (2-3 days per week at our Menlo Park facilities.)

Responsibilities:

• Strategic Design Leadership

• Own the complete UX vision and strategy for Unity''s patient and provider platforms, from research insights through final implementation

• Partner with product leadership to shape roadmaps, define priorities, and determine phased approaches that balance user needs, technical feasibility, and business goals

• Apply systems thinking to visualize and simplify complex relationships between patients, providers, lab processes, payer requirements, and data systems

• Transform scientific complexity into intuitive digital experiences that build trust and understanding

• Translate product strategy into actionable design initiatives that connect user journeys with clinical workflow realities

• End to End Design Execution

• Lead the complete design process from discovery and research through wireframing, prototyping, user testing, and final production-ready deliverables

• Create and maintain high-quality design artifacts: user flows, journey maps, wireframes, prototypes, and design system components that capture the full patient and clinician experience

• Own in-product microcopy and content strategy, ensuring every word builds clarity, confidence, and trust

• Drive the evolution of Unity''s design system, promoting consistency, scalability, and craft in partnership with branding and marketing teams

• Ensure accessibility, regulatory compliance, and ethical considerations are integrated into every design decision

• Lead user research initiatives to uncover insights that drive product strategy and design decisions

• Advocate for evidence-based design grounded in rigorous user research and testing methodologies

• Synthesize insights from clinicians, patients, and operational teams to identify unmet needs and design opportunities

• Champion the user perspective in cross-functional discussions, balancing clinical requirements, technical constraints, and business objectives

• Team Leadership and Collaboration

• Oversee and mentor junior designers and UX contractors, providing clear direction, constructive feedback, and opportunities for growth

• Build a culture of design excellence, systems thinking, and user advocacy within the design team and across the organization

• Partner with engineers to ensure the experiential quality of what ships matches design intent and maintains high craft standards

• Present and defend design decisions to stakeholders across product, clinical, and executive leadership

• Collaborate with product managers, engineers, clinicians, and genetic counseling teams to align design work with broader organizational goals

• Identify opportunities and drive initiatives independently while maintaining strategic alignment across teams

Qualifications:

• 7-10 years of professional experience in UX, product design, or service design
• 3+ years in leadership roles with demonstrated ability to own design strategy and guide team members
• Proven track record designing in healthcare, biotech, or similarly complex regulated environments
• An exceptional portfolio demonstrating systems-level thinking, strategic leadership, and user-centered problem solving from research through final execution
• Experience in both B2B and B2C healthcare product contexts preferred
• Background working with AI-powered product experiences a plus
• Track record of partnering with product management on prioritization and phased delivery approaches
• Expert-level skills in design and prototyping tools: Figma, Sketch, Miro, or similar platforms
• Deep understanding of user research methodologies, from generative research to usability testing
• Mastery of information architecture, interaction design principles, and UX best practices
• Strong grasp of accessibility standards (WCAG) and healthcare regulatory requirements (HIPAA, FDA)
• Experience creating and maintaining design systems at scale

Benefits And Perks:

• Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
• Open, transparent culture that includes weekly Town Hall meetings
• The ability to indirectly or directly change the lives of hundreds of thousands patients
• Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80%
• Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)
• Supplemental fertility benefits coverage
• Retirement savings program including a 4% Company match
• Increase paid time off with increased tenure
• Latest and greatest hardware (laptop, lab equipment, facilities)
• Daily on-site lunches provided from top eateries
• A variety of perks on campus (state of the art gym, restaurant)
• Free on-site EV charging (compatible with all EVs, including Tesla)

At BillionToOne, we are proud to offer a combination of a (1) base pay range (actual amount offered is based on experience and salary/equity options split that the candidate chooses), (2) generous equity options offering, (3) corporate bonus program, on top of (4) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave, etc.).

For this position, we offer a total compensation package of $317,881 per year, including a base pay range of $179,521 - $211,201 per year.

BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

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BillionToOne is a next-generation molecular diagnostics company on a mission to make powerful, accurate diagnostic tests accessible to everyone. Our revolutionary QCT molecular counting technology enhances disease detection resolution by over a thousandfold using cell-free DNA,a breakthrough that has already transformed the lives of over half a million patients worldwide.

Our Impact

Unity Complete is the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample.

Unity Confirm enables non-invasive confirmation for high-risk screening results through the capture of intact circulating fetal cells using BillionToOne's Fetal Cell Capture Technology.

Our Northstar liquid biopsy test uniquely combines treatment selection with real-time monitoring, giving oncologists unprecedented precision in cancer care.

Our Growth

From $0 to $150M+ in Annual Recurring Revenue in just five years. In 2025, we completed one of the most successful IPOs for a medical diagnostics company, building on nearly $400M in private funding,including our $130M Series D in 2024 and backed by world-class investors including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest.

Our Recognition

Forbes named us one of America''s Best Startup Employers for 2025 and we''re Great Place to Work certified, with 100% of our people willing to go the extra mile, even as we''ve scaled to over 700 employees.

Our Future

Headquartered in Menlo Park with facilities in Union City, CA, and a new lab opening in Austin, TX in 2027, we''re continuing to push the boundaries of what''s possible in molecular diagnostics. We''re just getting started.

Ready to help us change the world, one molecule at a time? Learn more at billiontoone.com