Group Lead, Assay Development - Molecular Biology & Bioinformatics (NGS)

Position Overview:

MyOme is seeking a group leader to lead NGS assay development with a focus on long-read sequencing assays. This person will lead and scale an integrated team across molecular assay development, computational pipeline R&D, with a company-wide impact. Proven experience in developing NGS assays with bioinformatic workflows are essential. The ideal candidate will also be a decisive leader, capable of navigating ambiguous situations to deliver results.

What You'll Do:

• Technology Leadership
  • Design and optimize end-to-end targeted NGS workflows with the assay team.
  • Institute stage gates on technology (R&D Pre-Validation Validation Release).
  • Build robustness across sample types (whole blood, saliva) and throughput modes.
  • Work with Clinical Lab Operations to define analytical performance claims (LoD/LoQ, precision, specificity, interference/cross-reactivity, carryover) and verification/validation study designs.
  • Supervise team development of research analysis pipelines, including definition of QC metrics and acceptance criteria for successful development
  • Establish truth sets, simulation frameworks, and benchmarking (GIAB, contrived mixes)
  • Define analytical performance under real-world conditions.
  • Collaborate with downstream bioinformatics teams for production hand-off.
• Team Development
  • Recruit, mentor, and develop a high-performing team of R&D scientists
  • Foster a culture of collaboration, innovation, and accountability within the lab.
• Program Management
  • Maintain single integrated roadmap for assays, pipelines, automation, and data operations with quarterly milestones mapped to product releases
  • Budgetary responsibilities
• Publications
  • Own the publication plan for assay components as well as IP strategy
  • Opportunities to present at conferences, engage in external collaborations

What You'll Need:

• Ph.D. in Molecular Biology, Biochemistry, Genetics, Bioengineering, Computational Biology, or related field; equivalent experience considered.
• 8+ years in NGS assay/product development, with experience leading multi-disciplinary teams.
• Demonstrated record of targeted NGS assay launches or molecular diagnostics productization.
• Bioinformatics proficiency: Linux, Python/R; variant calling (SNV/indel/CNV/SV); Cloud compute.
• Experience with a range of NGS platforms (e.g. Illumina, ONT, PacBio).
• Demonstrated success scaling labs and data systems, including LIMS integration and automated QC release.

Location, Compensation, and Benefits:

• Location: Onsite at our Menlo Park, CA laboratory campus. 
• Compensation: Annual base salary range is $170,000 - $230,000