Job Description\n \nGeneral Summary:\n \nVertex is a global biotechnology company on the forefront of scientific innovation. In addition to marketed therapies in cystic fibrosis (CF), sickle cell disease, beta-thalassemia, and moderate-to-severe acute pain , our research pipeline spans more than a dozen programs targeting the underlying mechanisms of serious diseases.\n \nVertex is seeking a talented and motivated individual to join its Global Health Economics & Outcomes Research (HEOR) group based in Boston's Seaport District. The HEOR Associate Director will participate in the shaping and execution of HEOR strategies that optimize the value proposition for Vertex's CF and early pipeline assets through each stage of development, including launch and post-launch phases. This position reports to the Executive Director HEOR, CF and Early Pipeline.\n \nKey Duties and Responsibilities:\n\n Leads execution of complex HEOR evidence generation studies, with focus on prospective and retrospective observational studies, COA strategy, and PRO measure development and validation, as well as systematic literature reviews, cost-effective analyses and budget impact models, indirect treatment comparisons, as needed, to support the asset value.\n Effectively leads external research partners to ensure robust scientific methods are applied to study design and execution and in compliance with all local regulations; is accountable for study design, data analysis and the quality of the evidence produced. Excellent project management is a pre-requisite to ensure studies delivered on time and within budget.\n Collaborates with the medical communications teams on publication strategy and ensure that dissemination of HEOR evidence is timely and has maximum impact\n Partners and works closely with Global Pricing and Market Access to support development of product value proposition/value messaging and co-lead development of robust Global launch deliverables (e.g., global value dossier)\n \nKnowledge and Skills:\n\n Strong track record of publication in peer-reviewed journals\n Strong background in clinical outcome assessment (COA) measurement strategy; experience in PRO development/validation and qualitative research methodology\n Technical expertise in HEOR with able to formulate and lead creative research projects and ensure conduct is technically and scientifically rigorous and reflects best HEOR practices; hands-on experience with prospective and site-based research is desired\n Strong verbal and written communications skills, including presentation skills to communicate difficult concepts and persuade others; comfortable communicating complex concepts and adapting presentation style to a variety of audiences\n Excellent project and people management skills to oversee vendors and internal project team, while aligning with cross-functional partners to ensure successful project execution, on timelines and budgets\n Ability to apply knowledge of US healthcare system, global health technology appraisal requirements, and clinical development, to identify evidence gaps and formulate evidence generation strategies\n Understanding of the legal and regulatory environment of the pharmaceutical industry, with spotless history of compliance and ethical workplace conduct\n \nEducation and Experience:\n\n Advanced degree (PhD, MD, Master's degree, MPH, or PharmD) in a relevant discipline.\n* Typically requires 8+ years of relevant experience, with substantial background in a Global HEOR role in a pharmaceutical/biotech setting, or the equivalent combination of education and experience\n \nPay Range:\n \n$176,000 - $264,000\n \nDisclosure Statement:\n \nThe range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.\n \nAt Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.\n \nFlex Designation:\n \nHybrid-Eligible Or On-Site Eligible\n \nFlex Eligibility Status:\n \nIn this Hybrid-Eligible role, you can choose to be designated as: \n \n1. Hybrid: work remotely up to two days per week; or select\n \n2. On-Site: work five days per week on-site with ad hoc flexibility.\n \nNote: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. \n \n#LI-Hybrid\n \nCompany Information\n \nVertex is a global biotechnology company that invests in scientific innovation. \n \nVertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. \n \nAny applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com\n\n