General Supervisor, Oncology

Ready to redefine what's possible in molecular diagnostics?

Join a team of brilliant, passionate innovators determined to transform healthcare. At BillionToOne, we've built a category-defining, publicly traded company on Nasdaq where transparency fuels trust, collaboration drives breakthroughs, and every contribution moves the needle on our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we build products that are 10x better than anything that exists today.

Our scientists, engineers, sales executives, and visionaries are united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion, and every innovation you contribute helps remove the fear of the unknown from some of life's most critical medical moments.

If you're driven by purpose, energized by innovation, and ready to help shape the future of precision medicine at scale, this is where you belong.

BillionToOne is seeking a Clinical Laboratory General Supervisor (GS) to support our Oncology product, Northstar, in a high-complexity CLIA laboratory environment. This role provides general supervision of personnel and daily laboratory operations, ensuring regulatory compliance, quality, and operational excellence across end-to-end cancer blood sample processing.

This is a hands-on leadership role in a fast-growing, high-throughput molecular diagnostics lab. The General Supervisor will serve as a key operational leader and first point of escalation for CLS and CLA, partnering closely with the Technical Supervisor, Laboratory Director, and Quality team.

This is an onsite position supporting the MondayFriday Mid Shift (11:30 AM 8:00 PM), with a planned transition to a PM shift (3:00 PM 11:30 PM) later this year.

Responsibilities:

• General Supervision & Leadership

• Serve as a designated CLIA General Supervisor for high-complexity testing in accordance with 42 CFR Part 493 and CAP accreditation standards

• Provide day-to-day supervision of laboratory personnel, including CLSs and CLAs, during the pre-analytic, analytic, and post-analytic phases of testing

• Act as the primary escalation point for technical, operational, and personnel issues during assigned shifts

• Oversee staffing, scheduling, shift handoffs, and workload distribution to ensure operational continuity

• Laboratory Operations & Testing

• Perform and oversee high-complexity molecular oncology assays, supporting diagnostic testing for patient care

• Ensure proper instrument operation, calibration, maintenance, and troubleshooting

• Review, interpret, and verify test results and quality control data

• Identify, investigate, and resolve deviations that may impact test performance or result integrity

• Quality & Compliance

• Ensure compliance with CLIA, CAP, state, and local regulatory requirements

• Perform, review, and document quality control, corrective actions, and preventive maintenance

• Participate in inspection readiness, audits, and regulatory responses

• Lead or support SOP development, review, and biennial updates

• Training & Continuous Improvement

• Lead training, onboarding, and competency assessments for new and existing laboratory staff

• Provide hands-on and theoretical training for new assays, processes, and instrumentation

• Support process improvement initiatives, including assay validation, tech transfer, and troubleshooting

• Partner cross-functionally with Quality, R&D, and Operations to drive continuous improvement

Qualifications:

• Active California Clinical Laboratory Scientist (CLS) license (or CGMBS/generalist license) meeting CLIA requirements for high-complexity testing
• Bachelors degree in chemical, biological, physical, clinical laboratory science, or a related field
• Minimum 4 years of clinical laboratory experience, including molecular and/or high-complexity testing
• Meets CLIA General Supervisor qualifications under 42 CFR 493.1461, including appropriate education, training, and experience
• Demonstrated hands-on experience with molecular biology techniques (e.g., DNA extraction, PCR, automated liquid handlers)
• Strong working knowledge of LIMS, quality systems, and laboratory documentation
• Proficiency with Google Docs, Excel, Word, and basic statistical analysis
• Excellent attention to detail, organizational skills, and ability to perform under time-sensitive conditions
• Strong written and verbal communication skills and a collaborative leadership style

Nice-To-Haves:

• Prior experience serving as a CLIA General Supervisor
• Startup or high-growth laboratory experience
• Background in medical genetics or oncology diagnostics
• Experience working with cell-free DNA (cfDNA) or next-generation sequencing workflows

Benefits And Perks:

• Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
• Open, transparent culture that includes weekly Town Hall meetings
• The ability to indirectly or directly change the lives of hundreds of thousands patients
• Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80%
• Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)
• Supplemental fertility benefits coverage 
• Retirement savings program including a 4% Company match
• Increase paid time off with increased tenure
• Latest and greatest hardware (laptop, lab equipment, facilities)
• Daily on-site lunches provided from top eateries
• A variety of perks on campus (state of the art gym, restaurant)
• Free on-site EV charging (compatible with all EVs, including Tesla)

At BillionToOne, we are proud to offer a combination of a (1) base pay range (actual amount offered is based on experience and salary/equity options split that the candidate chooses), (2) generous equity options offering, (3) corporate bonus program, on top of (4) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave, etc.).

For this position, we offer a total compensation package of $217,805 per year, including a base pay range of $158,401 - $179,521 per year.

BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

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BillionToOne is a next-generation molecular diagnostics company on a mission to make powerful, accurate diagnostic tests accessible to everyone. Our revolutionary QCT molecular counting technology enhances disease detection resolution by over a thousandfold using cell-free DNA,a breakthrough that has already transformed the lives of over half a million patients worldwide.

Our Impact

Unity Complete is the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample. Our Northstar liquid biopsy test uniquely combines treatment selection with real-time monitoring, giving oncologists unprecedented precision in cancer care.

Our Growth

From $0 to $150M+ in Annual Recurring Revenue in just five years. In 2025, we completed one of the most successful IPOs for a medical diagnostics company, building on nearly $400M in private funding,including our $130M Series D in 2024 and backed by world-class investors including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest.

Our Recognition

Forbes named us one of America's Best Startup Employers for 2025 and we're Great Place to Work certified, with 100% of our people willing to go the extra mile, even as we've scaled to over 700 employees.

Our Future

Headquartered in Menlo Park with facilities in Union City, CA, and a new lab opening in Austin, TX in 2027, we're continuing to push the boundaries of what's possible in molecular diagnostics. We're just getting started.

Ready to help us change the world, one molecule at a time? Learn more at billiontoone.com