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Job Description

About the Role

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join Takeda as a Director, Drug Metabolism, Pharmacokinetics & Modeling (DMPK&M) within the Gastrointestinal and Inflammation (GI2) Therapeutic Area Unit. This role provides strategic leadership across gastrointestinal and inflammatory disease programs, integrating ADME, pharmacokinetics/pharmacodynamics, and quantitative modeling to drive decisions from early discovery through clinical development.

How You Will Contribute

• Provide strategic leadership for DMPK&M across multiple GI2 programs
• Serve as the DMPK&M representative on cross-functional research or global project teams
• Design and execute ADME strategies supporting IND and clinical progression
• Drive quantitative decision-making using modeling approaches (PBPK, mechanistic PK/PD, early feasibility analysis)
• Enable prediction of human PK, dose selection, tissue exposure, and target engagement
• Identify and mitigate risks such as DDI, variability, and absorption challenges
• Contribute to regulatory submissions and health authority interactions
• Collaborate cross-functionally with clinical pharmacology, safety, CMC and regulatory
• Manage resources and plan budgets efficiently for DMPK&M
• Mentor junior scientists and foster data-driven culture
• Contribute to publications and external scientific engagement

Education and Experience

• PhD with 10+ years experience, or MS with 16+, or BS with 18+
• Experience across drug discovery and development
• Proven leadership and experience working on cross-functional project teams
• Strong background in ADME, translational science and human PK prediction
• Experience collaborating with pharmacometrics or QSP teams
• Knowledge of regulatory expectations (FDA, EMA, ICH)
• Ability to integrate PK, PD, safety, and efficacy data

Additional Preferred Qualifications

• Experience in applying quantitative frameworks i.e. modeling & simulation to guide strategic decisions
• Experience in GI2 disease area is a plus

Behavioral Competencies

• Strategic thinker with strong scientific judgment
• Ability to lead in matrixed environment
• Strong communication skills
• Collaborative mindset
• Ability to prioritize and drive decisions

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. 

For Location:

U.S. Base Salary Range:

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. 

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. 

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

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It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

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