Support the IPP (Induced Proximity Platform) Development group.
Individual will provide laboratory support for protein purification activities and associated experiments.
This is a 100% onsite laboratory role in South San Francisco.
Schedule: Monday Friday 8:00 AM 5:00 PM Standard laboratory hours
Occasional overtime may be required with manager approval
Weekend work not expected
The ideal candidate is a hands-on laboratory scientist with strong protein purification experience who enjoys bench work and can independently execute laboratory protocols with accuracy. They should be detail-oriented, organized, capable of documenting results thoroughly, and able to communicate findings clearly with the team.
This role is heavily focused on laboratory execution rather than experimental design, making prior hands-on purification experience significantly more important than broad research experience.
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Required Technical Experience
Hands-on protein purification experience (highest priority)
Strong laboratory bench skills with extensive wet-lab experience
Experience with one or more of:
A KTA
FPLC
HPLC
Comfortable working in a laboratory environment 100% of the time
Experience following laboratory protocols accurately
Strong documentation and recordkeeping skills
Able to communicate experimental results clearly
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Location:
South San Francisco, CA
Department:
Discovery Protein Science
Position Summary:
The Associate Scientist will support protein and antibody production, purification, and analytical activities within the Discovery Protein Science department. This role will primarily support the Induced Proximity Platform by executing established protein production and characterization workflows. The individual will contribute to multiple protein production requests, maintain accurate experimental records, and collaborate with cross-functional scientists to deliver high-quality protein reagents in a fast-paced research environment.
Key Responsibilities:
Perform AKTA/FPLC-based purifications (Affinity, ion-exchange (IEX), hydrophobic interaction chromatography (HIC), size-exclusion chromatography (SEC) and other chromatography-based methods) with a focus on antibody-based molecules.
Perform biochemical and biophysical characterization of proteins and antibodies using analytical HPLC, SDS-PAGE, endotoxin testing and LC-MS.
Perform transient and stable mammalian cell expression of recombinant proteins and antibodies, as needed.
Maintain detailed laboratory documentation and experimental records.
Support inventory management, reagent preparation, and laboratory organization.
Basic Qualifications:
Associate's or Bachelor's degree in Biology, Biochemistry, Biotechnology, Molecular Biology, or a related scientific discipline
Minimum of 2 years of hands-on laboratory experience in protein purification, protein analytics, or related biologics research in an academic or industry setting
Proficiency with AKTA/FPLC chromatography systems, HPLC and related laboratory equipment
Experience with protein characterization and analytical techniques
Ability to follow established protocols with strong attention to detail
Effective written and verbal communication skills
Preferred Qualifications:
Knowledge of antibody formats, isotypes and structures
Understanding of sterile technique and mammalian cell culture practices
Familiarity with automation such as KingFisher and Hamilton
Hands-on experience in DNA construct design and molecular cloning
Demonstrated ability to work effectively in a collaborative, cross-functional research environment
Demonstrated scientific analysis and problem-solving skills