Senior Scientist I - Computational Biologist
Joulé
Rockville, MD
JOB DETAILS
SALARY
$45–$70 Per Hour
SKILLS
Analysis Skills, Antibodies, Artificial Intelligence (AI), Automation, Biochemistry, Bioengineering, Bioinformatics, Biology, Biophysics, Biotech and Pharmaceutical, Cancer, Cloning, Computational Engineering, Computer Programming, Computer Science, Data Analysis, Data Modeling, Data Processing, Data Sets, Deep Learning, Machine Learning, Molecular Biology, Next Generation Sequencing (NGS), Physics, Predictive Modeling, Publications, Python Programming/Scripting Language, Team Player
LOCATION
Rockville, MD
POSTED
13 days ago
Location: Rockville, MD (100% Onsite)
Hours/Schedule: Monday–Friday, 9:00 AM – 5:00 PM
Compensation: $45.00 – $70.00/hour
Type: Contract (6 months, extension possible but not guaranteed)
Overview
Leading biotechnology organization focused on cancer therapeutics is seeking a Senior Scientist, Computational Biology to support next-generation antibody discovery. This is a highly impactful, first-of-its-kind role within the organization, working at the intersection of structural biology, computational modeling, and AI-enabled protein engineering.
Responsibilities
- Develop and apply computational methods to engineer monoclonal and bispecific antibodies (90% computational/10% bench work)
- Integrate deep-learning and physics-based models for protein structure prediction and developability assessment
- Analyze structural biology and NGS datasets to guide antibody library design and optimization
- Build and maintain Python-based bioinformatics and machine learning workflows for data processing and modeling
- Collaborate closely with experimental scientists to translate computational insights into actionable design decisions
- Perform limited bench-based molecular biology work, including cloning and experimental support (up to 10%)
Requirements
- Ph.D. in Structural Biology, Biochemistry, Biophysics, Protein Sciences, Computational Biology, Bioengineering, Machine Learning, Computer Science, or related field with 0–3 years postdoctoral experience OR; Master’s degree with 5+ years of relevant industry experience
- Strong background in structural biology, including peer-reviewed publications
- Hands-on experience with protein modeling and structure prediction tools such as AlphaFold, RosettaFold, Schrödinger, MOE, or RFdiffusion
- Advanced Python programming skills for data analysis, automation, and ML workflow integration
- Experience with NGS data analysis and bioinformatics pipelines
- Familiarity with AI/ML approaches in protein engineering preferred but not required if structural biology and Python expertise are strong
- Ability to work effectively in highly collaborative, interdisciplinary research teams
- Must be legally authorized to work in the United States for any employer
Benefits
System One offers eligible employees health and welfare benefits coverage options, including medical, dental, vision, spending accounts, life insurance, voluntary plans, and participation in a 401(k) plan.
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About the Company
J
Joulé
With extensive scientific, clinical, and healthcare industry experience, Joulé recruiters excel at placing talent across core specialty areas:
- Scientific staffing for hard-to-find skills
Working across every scientific discipline, Joulé places biologists, chemists, scientists, technicians and other specialists.
- Clinical lifecycle recruiting
From research to regulations, safety to statistics, Joulé helps clients manage every stage of the clinical development lifecycle.
- Equipment calibration, maintenance and validation
Laboratory and facility support comes with a total quality commitment backed by ISO 9001:2008 certification.
- National healthcare recruitment
Trust Joulé’s extensive experience in physician, advanced practice provider and executive direct placement search.
COMPANY SIZE
500 to 999 employeesINDUSTRY
Biotechnology/Pharmaceuticals
WEBSITE
https://www.jouleinc.com/