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Pathology Research Sr. Scientist - Advanced Imaging at

Pathology Research Sr. Scientist - Advanced Imaging

South San Francisco, CA Full-Time

Job Description

Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology we collaborate to discover the next medical breakthrough.We are seeking a motivated, experienced scientist with experience in tissue-based assays and image analysis to support discovery and translational research in our pathology group. The successful candidate will implement molecular and histopathological techniques to multiplexed imaging and apply quantitative image analysis to identify novel biological targets for cancer therapy and elucidate mechanism of action. Experience with the Akoya Phenocycler and/or Vectra systems, as well as comfort and facility with image analysis software and/or opensource tools are highly desirable.

The successful candidate will:

Develop and validate staining protocols and analysis parameters for quantitation of multiplexed assays examining various molecular targets in intact human tissues.Develop and apply analytic methods to phenotype cell populations and quantitate and spatially characterize molecular targets in situ within tissue sections.Interact seamlessly with pathologists, IHC bench scientists, histotechnicians, and other stakeholders to drive projects with quantitative imaging endpoints.Serve as a representative of the Anatomic Pathology group and a functional area expert on project teams.Present data in team meetings and participate in generation of technical reports in support of regulatory documents.This position will require excellent communication and interpersonal skills, high capacity and enthusiasm to work collaboratively with others both within and outside the department, and a strong drive to solve problems, overcome obstacles, and innovate. The successful candidate will have a high level of comfort with complex multitasking; be self-motivated and productive; and be able to work independently, with minimal oversight.


Required Education:

Bachelor or Graduate degree with extensive related experience; PhD (biology, pathology, immunology, oncology or related field) strongly preferred.

Required Skills and Experience:

Experience with immunohistochemistry and multiplexed immunofluorescence.Experience with digital whole-slide images visualization and quantitative image analysis.

Preferred Skills and Experience:

Significant scientific engagement and leadership as evidenced through publications and presentations. High level of comfort with histology/microanatomy strongly preferred.Experience in processing and manipulating large datasets with R or Python programming language.Background in immunology, pathology, oncology, and/or computational biology.Background in machine learning.Previous experience in the pharmaceutical industry.We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe. Who we are … We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.What we look for … Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.NOTICE FOR INTERNAL APPLICANTSIn accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the


Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.For positions located in the United States and Puerto Rico – Subject to applicable law, all new hires (including internal transfers) must demonstrate that they are fully vaccinated against COVID-19 or that they qualify for a medical or religious exemption to this vaccination requirement. New hires (including internal transfers) to a position that, as determined by the Company, requires routine collaboration with external stakeholders (such as roles in health services or customer-facing commercial or research-based roles) (“Customer-Facing Role”) who are not vaccinated must qualify for a medical or religious exemption and be in a position that the Company determines can accommodate unvaccinated employees without causing an undue burden to business operations. If, following dialog with the candidate as appropriate, it is determined that the candidate either a) does not qualify for a religious or medical exemption or, b) for candidates applying for Customer-Facing roles, it is determined that allowing the candidate to work without vaccination would cause an undue burden to the Company, the candidate will be ineligible for hire or transfer, or any offer of employment or transfer (if applicable) will be revoked. Please note that notwithstanding the approval of any reasonable accommodation, the Company reserves the right to monitor, modify, or revoke any such accommodation if it is determined, following dialog with the employee, that the accommodation is no longer effective or results in an undue burden to the Company.Current Employees apply HERECurrent Contingent Workers apply HEREUS and Puerto Rico Residents Only:Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.For more information about personal rights under Equal Employment Opportunity, visit:EEOC PosterEEOC GINA Supplement​OFCCP EEO SupplementPay Transparency NondiscriminationWe are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Residents of Colorado:

Click here to request this role’s pay range. Search Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

RegularRelocation:DomesticVISA Sponsorship:YesTravel


No Travel RequiredFlexible Work Arrangements:Shift:Valid Driving License:Hazardous Material(s):Number of Openings: 1


Location: USA - California - South San Francisco (Grand Ave)Type: Full time

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