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Research Associate, Assay Development

GUARDANT HEALTH, INC Redwood City Full-Time
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Company Description  


Guardant Health develops breakthrough diagnostic technologies to improve cancer management. With Guardant360, we offer real-time, biopsy-free tumor sequencing that tracks tumor genomics in real-time and identifies associated treatment options. The assay is used by more than 6,000 oncologists and we partner with more than 50 biopharma companies.

Guardant Health raised over $550M from Sequoia Capital, Khosla Ventures, Lightspeed Ventures, OrbiMed and Softbank, before having a successful IPO on NASDAQ in 2018. Guardant is led by a seasoned management team of thought leaders and successful serial entrepreneurs in next generation sequencing and rare cell diagnostics. They are advised by an oncologist-led medical steering committee from leading cancer centers.

Job Description  

To enable Guardant Health to lead the disruption of cancer treatments through non-invasive cancer screening, the Technology Development Team is seeking a highly motivated Research Associate to help develop, test and validate novel technologies for rare variant studies with next-generation sequencing. At Guardant, we leverage the most advanced technologies and work with leaders in many different fields to create the most impactful and meaningful technologies for cancer management.
As a Research Associate in the Technology Development team, you will work with members in the team and collaborate cross-functionally with members of technology development, bioinformatics, process engineering, automation, clinical development and operations. You will be hands-on in the lab, participating in efforts to develop, implement, validate, and transfer assays to our clinical lab. You will participate in teams supporting the maintenance and development of IVD and LDT products. An ideal candidate would have some level of experience with NGS assay development, working with automated platforms, and working in a regulated environment. 

Execute studies aimed at improving and streamlining NGS assays
Collaborate cross-functionally to facilitate the effective transfer of methods and processes to the CLIA lab
Ensure all work is performed and documented in compliance with applicable regulatory and quality practices (FDA, ISO13485)
Present data, proposals, and progress at team meetings


Strong foundation in molecular biology techniques, with preferred experience in the areas of sample preparation for NGS
Demonstrated ability to organize, document and communicate scientific data 
Sense of humor is a must
Consummate team player: demonstrated ability to contribute in an environment where numerous contributions are required to accomplish complex goals
Enjoy working independently and collaboratively in a fast-paced environment and able to adapt to change
Quantitative/analytical mindset- ability to segment complex problems into fundamental parts/basic principles, develop models and experimental tests for those models, and synthesize results into actionable solutions
Curiosity and drive

Experience in the following areas is highly desirable:
Product development in a regulated environment 
Experience with NGS data analysis tools (Python, R, etc.)
Experience with assay development for automated liquid handling platforms

Your background includes:

 BSc. in Molecular Biology, Bioengineering, Biochemistry or related field

The ability to handle biological samples (i.e. tissue, biofluid, etc) is a must

Willing to do manual, repetitive lab work is a must

Excellent written and oral communication skills

Hands-on experience in running NGS sequencing platforms and assays

Experience with process automation for nucleic acid extraction and sample preparation

Experience working under design control is strongly preferred (IVD development is plus)

Additional Information  

All your information will be kept confidential according to EEO guidelines.


Skills required

Molecular Biology
Cell Cultures
Cell Biology
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Job ID: REF671R


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Guardant Health has helped thousands of oncologists learn accurate and actionable information about tens of thousands of patients, while avoiding the costs and risks of tissue biopsies. Our genomic test helps match advanced-cancer patients to approved targeted therapies as well as drugs in clinical trials. Guardant Health is a pioneer in non-invasive cancer diagnostics and the first company to commercialize a comprehensive genomic liquid biopsy.

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