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  • Menlo Park, CA 94025

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Downstream Manufacturing Associate II

Ascent • Menlo Park, CA

Posted 10 days ago

Job Snapshot

Experience - At least 5 year(s)
Pharmaceutical, Biotechnology
Biotech, Pharmaceutical, Manufacturing


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Job Description

Downstream Manufacturing Associate II
Menlo Park, CA

Our highly skilled and talented Process Development team is looking to bring onboard a Downstream Manufacturing Associate II to help support the continued development, manufacturing and commercialization of our AAV vectors for our therapies that address both our rare diseases programs as well as our Ophthalmology programs.

  • Help with manufacturing of AAV through the downstream purification process (post cell lysate to final formulation)
  • Optimize, revise, and update current processes to make them more robust and streamlined
  • Pursue work with the goal of improving the existing AAV purification process, optimizing, revising, and updated for robustness and efficiency / streamline.
  • Work hands-on to develop, optimize, and scale-up downstream processes from small to large scale purification systems in the laboratory setting for the purification of AAV vectors.
  • Design and execute experiments following appropriate laboratory procedures and produce competent and reproducible results to a high technical standard.
  • Appropriately analyze data, interpret results, and maintain accurate records with minimum supervision.
  • Interact with Assay Development, QC, QA, and pre-clinical group.
  • Develop Client AAV manufacturing processes with the highest quality on time to advance Adverum's product pipeline.
  • Ensure safe work place in compliance with the company and EHS rules and regulations.
  • Keep current with advances in downstream processes for viral vector production.
  • MS with 2-4 years of experience or BS with 4+ years of experience in Chemical Engineering, Biochemistry, Cell & Molecular Biology or related life science engineering fields.
  • Hands on experience with TFF (Hollow Fiber / Cassettes) UD/DF, Client AKTA (Avant, Pilot), chromatography at small/pilot/large scale is required.
  • Proficient in theory of chromatography and protein purification.
  • Proficient in general molecular biology techniques including ELISA, qPCR, BCA.
  • Experience drafting SOPs, Batch records, reports, and protocols is required.
  • Broad experience in cGMP biologics manufacturing and documentation required, with additional understanding of regulatory guidelines preferred.
  • Highly motivated team player capable of leading by example and who exceeds expectations in all aspects of the role.
  • Hands-on experience in the insect cell-baculovirus expression technology platform is a plus.
Job ID: 18-04592
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