Job Description: Role Summary:
The Tumor Cell Biology Department of the *** Oncology Research division is seeking a full time contractor to join our drug discovery team. The scientist/biochemist will make important contributions to the discovery and pre-clinical development of oncology therapeutics. In particular, the biochemist will be responsible for the development and validation of robust, reproducible plate-based enzyme and cell assays. This will include mechanistic studies to characterize enzyme targets, reaction pathways, and mechanism of action of lead compounds. This may also include development of assays which measure ligand-receptor interaction using purified proteins, membrane preparations or cells. Candidate will be responsible for testing lead compounds in biochemical and cellular assays, data analysis, and proper database publication of data. Candidate will participate on project teams, providing insight and technical expertise required for project progression.
Knowledge of biochemistry theory and practice
Experience in in vitro assay development, cell culture, and data analysis/interpretation
Experience with automation of assays, LC-MS, radio-labeled ligand binding, fluorescence, and coupled-enzyme assays is also desired
Experience with standard Windows 10, Microsoft Office including Excel, and GraphPad Prism. Candidate must be able to quickly learn new in-house software for data management.
Must have strong oral and written communication skills.
Must be competent in standard chemical calculations to accurately prepare laboratory solutions and calculate dilutions for screening.
The candidate must be flexible, organized and attentive to details.
Accurate record keeping and ability to follow precise steps in a protocol are required.
Ability to multi-task, able to independently analyze data, troubleshoot and solve problems.
Ability to work independently and contribute to team goals in a collaborative environment.
Preference for candidates with pharmaceutical/biotech drug discovery experience evaluating small-molecule inhibitors of enzyme or receptor targets.
The job requirement is for a full-time research contractor available Monday Friday during standard working hours. BS or BS/MS with 2-3 years or more experience in industry or relevant academic lab. Candidate will have extensive experience in biochemical and cellular assay development and validation. Experience in cancer research, drug discovery, immunology, or cross discipline skills which can be applied to drug discovery.
Physical and Mental requirements
Work at lab bench and at desk.
Work with standard radioactive materials (3H, 32P, etc).
Ability to process and analyze raw data using software programs including Excel, GraphPad Prism and Activity Base.
Must maintain an electronic lab notebook.
Good Manufacturing Practices